Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Marc P. Windisch"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Bioluminescence resonance energy transfer (BRET) saturation is a method of studying protein–protein interaction (PPI) upon quantification of the dependence of the BRET signal on the acceptor/donor (A:D) expression ratio. In this study, usi
Externí odkaz:
https://doaj.org/article/ff33b828cc32409194b9af61c58a9767
Autor:
Ganesh Selvaraj Duraisamy, Eunji Jo, Ivana Huvarová, Kyu-Ho P. Park, Zbyněk Heger, Vojtěch Adam, Daniel Růžek, Marc P. Windisch, Andrew D. Miller
Publikováno v:
Heliyon, Vol 8, Iss 9, Pp e10465- (2022)
Ginsenosides are a class of natural steroid glycosides and triterpene saponins found in Panax ginseng. After screening of a commercial ginsenoside compound library for low cellular cytotoxicity and the ability to mediate efficient reductions in hepat
Externí odkaz:
https://doaj.org/article/a8de4d1d5ad84c698c444ee4e38e4f30
Autor:
Aleksandr Ianevski, Rouan Yao, Ronja M. Simonsen, Vegard Myhre, Erlend Ravlo, Gerda D. Kaynova, Eva Zusinaite, Judith M. White, Stephen J. Polyak, Valentyn Oksenych, Marc P. Windisch, Qiuwei Pan, Eglė Lastauskienė, Astra Vitkauskienė, Algimantas Matukevičius, Tanel Tenson, Magnar Bjørås, Denis E. Kainov
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104112- (2022)
Summary: Broadly effective antiviral therapies must be developed to be ready for clinical trials, which should begin soon after the emergence of new life-threatening viruses. Here, we pave the way towards this goal by reviewing conserved druggable vi
Externí odkaz:
https://doaj.org/article/77ed5cbd497a44c69e58bc71d4d6eb97
Autor:
Mariano Genera, Barbara Quioc-Salomon, Antonin Nourisson, Baptiste Colcombet-Cazenave, Ahmed Haouz, Ariel Mechaly, Mariette Matondo, Magalie Duchateau, Alexander König, Marc P. Windisch, Christine Neuveut, Nicolas Wolff, Célia Caillet-Saguy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Interactions between the hepatitis B virus core protein (HBc) and host cell proteins are poorly understood, although they may be essential for the propagation of the virus and its pathogenicity. HBc has a C-terminal PDZ (PSD-95, Dlg1, ZO-1)-
Externí odkaz:
https://doaj.org/article/1aa13d44608f4a1a8117b0820723178a
Autor:
Aleksandr Ianevski, Rouan Yao, Eva Zusinaite, Laura Sandra Lello, Sainan Wang, Eunji Jo, Jaewon Yang, Erlend Ravlo, Wei Wang, Hilde Lysvand, Kirsti Løseth, Valentyn Oksenych, Tanel Tenson, Marc P. Windisch, Minna M. Poranen, Anni I. Nieminen, Svein Arne Nordbø, Mona Høysæter Fenstad, Gunnveig Grødeland, Pål Aukrust, Marius Trøseid, Anu Kantele, Eglė Lastauskienė, Astra Vitkauskienė, Nicolas Legrand, Andres Merits, Magnar Bjørås, Denis E. Kainov
Publikováno v:
Viruses, Vol 13, Iss 12, p 2489 (2021)
Background: There is an urgent need for new antivirals with powerful therapeutic potential and tolerable side effects. Methods: Here, we tested the antiviral properties of interferons (IFNs), alone and with other drugs in vitro. Results: While IFNs a
Externí odkaz:
https://doaj.org/article/fdd3427c779b42a5b595834a986d6d6d
Autor:
Korbinian Bösl, Aleksandr Ianevski, Thoa T. Than, Petter I. Andersen, Suvi Kuivanen, Mona Teppor, Eva Zusinaite, Uga Dumpis, Astra Vitkauskiene, Rebecca J. Cox, Hannimari Kallio-Kokko, Anders Bergqvist, Tanel Tenson, Andres Merits, Valentyn Oksenych, Magnar Bjørås, Marit W. Anthonsen, David Shum, Mari Kaarbø, Olli Vapalahti, Marc P. Windisch, Giulio Superti-Furga, Berend Snijder, Denis Kainov, Richard K. Kandasamy
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways and evade innate immune r
Externí odkaz:
https://doaj.org/article/d157fa54b4a44568a582c23118069246
Autor:
Meehyun Ko, So Young Chang, Soo Young Byun, Aleksandr Ianevski, Inhee Choi, Anne-Laure Pham Hung d’Alexandry d’Orengiani, Erlend Ravlo, Wei Wang, Magnar Bjørås, Denis E. Kainov, David Shum, Ji-Young Min, Marc P. Windisch
Publikováno v:
Viruses, Vol 13, Iss 4, p 651 (2021)
Therapeutic options for coronaviruses remain limited. To address this unmet medical need, we screened 5406 compounds, including United States Food and Drug Administration (FDA)-approved drugs and bioactives, for activity against a South Korean Middle
Externí odkaz:
https://doaj.org/article/f21ab46b682142fdb986507f13718ee8
Autor:
Aleksandr Ianevski, Rouan Yao, Svetlana Biza, Eva Zusinaite, Andres Mannik, Gaily Kivi, Anu Planken, Kristiina Kurg, Eva-Maria Tombak, Mart Ustav, Nastassia Shtaida, Evgeny Kulesskiy, Eunji Jo, Jaewon Yang, Hilde Lysvand, Kirsti Løseth, Valentyn Oksenych, Per Arne Aas, Tanel Tenson, Astra Vitkauskienė, Marc P. Windisch, Mona Høysæter Fenstad, Svein Arne Nordbø, Magnar Bjørås, Denis E. Kainov
Publikováno v:
Viruses, Vol 12, Iss 10, p 1178 (2020)
Combination therapies have become a standard for the treatment for HIV and hepatitis C virus (HCV) infections. They are advantageous over monotherapies due to better efficacy, reduced toxicity, as well as the ability to prevent the development of res
Externí odkaz:
https://doaj.org/article/2ac1bf6815cf4ea9a46bc5b3518c6f3c
Autor:
Ganesh Selvaraj Duraisamy, Dattatry Bhosale, Ivana Lipenská, Ivana Huvarova, Daniel Růžek, Marc P. Windisch, Andrew D. Miller
Publikováno v:
Viruses, Vol 12, Iss 9, p 998 (2020)
The management of chronic hepatitis B virus (CHB) infection is an area of massive unmet clinical need worldwide. In spite of the development of powerful nucleoside/nucleotide analogue (NUC) drugs, and the widespread use of immune stimulators such as
Externí odkaz:
https://doaj.org/article/074225b0ebaf433a9b27baffbad1528c
Autor:
Oliver Grünvogel, Katharina Esser-Nobis, Marc P. Windisch, Michael Frese, Martin Trippler, Ralf Bartenschlager, Volker Lohmann, Marco Binder
Publikováno v:
Genomics Data, Vol 7, Iss , Pp 166-170 (2016)
Most studies investigating the biology of Hepatitis C virus (HCV) have used the human hepatoma cell line Huh-7 or subclones thereof, as these are the most permissive cell lines for HCV infection and replication. Other cell lines also support replicat
Externí odkaz:
https://doaj.org/article/c09b8c73cbea4c2788f92047667582e4