Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Marc P. Forrest"'
Autor:
Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The 16p11.2 duplication confers risk for autism and schizophrenia, but the disease mechanisms are unknown. Here, the authors use proteomics to show dysregulation of synaptic and epilepsy-associated protein networks in the cortex of model mice, and de
Externí odkaz:
https://doaj.org/article/d8bd400d64534b3a8bce832350e7bb51
Autor:
Sehyoun Yoon, Marc Dos Santos, Marc P. Forrest, Christopher P. Pratt, Natalia Khalatyan, Peter J. Mohler, Jeffrey N. Savas, Peter Penzes
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112784- (2023)
Summary: Rare genetic variants in ANK2, which encodes ankyrin-B, are associated with neurodevelopmental disorders (NDDs); however, their pathogenesis is poorly understood. We find that mice with prenatal deletion in cortical excitatory neurons and ol
Externí odkaz:
https://doaj.org/article/2e405b575a864345a6945ca6fb17a8ae
Autor:
Alena Kozlova, Siwei Zhang, Alex V. Kotlar, Brendan Jamison, Hanwen Zhang, Serena Shi, Marc P. Forrest, John McDaid, David J. Cutler, Michael P. Epstein, Michael E. Zwick, Zhiping P. Pang, Alan R. Sanders, Stephen T. Warren, Pablo V. Gejman, Jennifer G. Mulle, Jubao Duan
Publikováno v:
Am J Hum Genet
Identifying causative gene(s) within disease-associated large genomic regions of copy-number variants (CNVs) is challenging. Here, by targeted sequencing of genes within schizophrenia (SZ)-associated CNVs in 1,779 SZ cases and 1,418 controls, we iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53797a3fcb8041accdd6f2b9b098636c
https://doi.org/10.1016/j.ajhg.2022.07.001
https://doi.org/10.1016/j.ajhg.2022.07.001
Autor:
Euan Parnell, Lorenza Culotta, Marc P. Forrest, Hiba A. Jalloul, Blair L. Eckman, Daniel D. Loizzo, Katherine K.E. Horan, Marc Dos Santos, Nicolas H. Piguel, Derek J.C. Tai, Hanwen Zhang, Tracy S. Gertler, Dina Simkin, Alan R. Sanders, Michael E. Talkowski, Pablo V. Gejman, Evangelos Kiskinis, Jubao Duan, Peter Penzes
Publikováno v:
Biological psychiatry.
Schizophrenia (SCZ) is a debilitating psychiatric disorder with a large genetic contribution; however, its neurodevelopmental substrates remain largely unknown. Modeling pathogenic processes in SCZ using human induced pluripotent stem cell-derived ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315bd9b5a3951957a3a1c0a286444c7d
https://pubmed.ncbi.nlm.nih.gov/36581494
https://pubmed.ncbi.nlm.nih.gov/36581494
Autor:
Siwei Zhang, Hanwen Zhang, Marc P. Forrest, Yifan Zhou, Vikram A. Bagchi, Alena Kozlova, Marc Dos Santos, Nicolas H. Piguel, Leonardo E. Dionisio, Alan R. Sanders, Zhiping P. Pang, Xin He, Peter Penzes, Jubao Duan
Despite hundreds of risk loci from genome-wide association studies of neuropsychiatric disorders, causal variants/genes remain largely unknown. Here, in NEUROG2-induced human neurons, we identified 31 risk SNPs in 26 schizophrenia (SZ) risk loci that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78438acfd89723a37954f48b8119acde
https://doi.org/10.1101/2021.12.11.472229
https://doi.org/10.1101/2021.12.11.472229
Autor:
M Dolores, Martín-de-Saavedra, Marc, Dos Santos, Lorenza, Culotta, Olga, Varea, Benjamin P, Spielman, Euan, Parnell, Marc P, Forrest, Ruoqi, Gao, Sehyoun, Yoon, Emmarose, McCoig, Hiba A, Jalloul, Kristoffer, Myczek, Natalia, Khalatyan, Elizabeth A, Hall, Liam S, Turk, Antonio, Sanz-Clemente, Davide, Comoletti, Stefan F, Lichtenthaler, Jeffrey S, Burgdorf, Maria V, Barbolina, Jeffrey N, Savas, Peter, Penzes
Publikováno v:
Neuron
While many neuronal, membrane proteins undergo proteolytic cleavage, little is known about the biological significance of neuronal ectodomain shedding (ES). Here, we show that the neuronal sheddome is detectable in human cerebrospinal fluid (hCSF) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::985e4b81ac4a25d2d5b2fbee13d702c6
https://pubmed.ncbi.nlm.nih.gov/34921780
https://pubmed.ncbi.nlm.nih.gov/34921780
Autor:
Hanwen Zhang, Marc P. Forrest, Leonardo E. Dionisio, Nicholas Piguel, Alan R. Sanders, Siwei Zhang, Xin He, Zhiping P. Pang, Alena Kozlova, Marc Dos Santos, Peter Penzes, Yifan Zhou, Vikram Bagchi, Jubao Duan
Publikováno v:
European Neuropsychopharmacology. 51:e50-e51
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::869f699c9b4558761b3e9e7f49fdc2e3
https://doi.org/10.1016/j.euroneuro.2021.07.112
https://doi.org/10.1016/j.euroneuro.2021.07.112
Autor:
Reshma R. Desai, John Millichap, Kelly A Marshall, Evangelos Kiskinis, Gabriella L Robertson, Marc P. Forrest, Linda Laux, Dina Simkin, Alfred L. George, Peter Penzes, Steven J. Lubbe, Bernabé I. Bustos, Juan A. Ortega, Brandon N Piyevsky, Carlos G. Vanoye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0bf16ea33ef217dbd275aa0d951f319
https://doi.org/10.7554/elife.64434.sa2
https://doi.org/10.7554/elife.64434.sa2
Autor:
Steven J. Lubbe, Gabriella L Robertson, Carlos G. Vanoye, Reshma R. Desai, Peter Penzes, John Millichap, Evangelos Kiskinis, Bernabé I. Bustos, Kelly A Marshall, Dina Simkin, Brandon N Piyevsky, Alfred L. George, Juan A. Ortega, Linda Laux, Marc P. Forrest
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
eLife
eLife, Vol 10 (2021)
Universidad de Barcelona
eLife
eLife, Vol 10 (2021)
Mutations in KCNQ2, which encodes a pore-forming K+ channel subunit responsible for neuronal M-current, cause neonatal epileptic encephalopathy, a complex disorder presenting with severe early-onset seizures and impaired neurodevelopment. The conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb3f591130ed352737002c9c4ded72b
http://hdl.handle.net/2445/185597
http://hdl.handle.net/2445/185597
Autor:
Dennis R. Grayson, Jenny Drnevich, Vikram Saudagar, Alessandro Guidotti, Lindsay V. Clark, Robert C. Smith, Marc P. Forrest, Henry Sershen, Eleonora Gatta, James Auta, John M. Davis
Publikováno v:
Schizophrenia Bulletin Open
Schizophrenia is a severe neuropsychiatric disorder associated with a wide array of transcriptomic and neurobiochemical changes. Genome-wide transcriptomic profiling conducted in postmortem brain have provided novel insights into the pathophysiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd349ae6de3ddf17a328530f94fb7d2
https://doi.org/10.1093/schizbullopen/sgab002
https://doi.org/10.1093/schizbullopen/sgab002