Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Marc P Windisch"'
Autor:
Mahmoud ElHefnawi, TaeKyu Kim, Mona A Kamar, Saehong Min, Nafisa M Hassan, Eman El-Ahwany, Heeyoung Kim, Suher Zada, Marwa Amer, Marc P Windisch
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159211 (2016)
RNA interference (RNAi) is a post-transcriptional gene silencing mechanism that mediates the sequence-specific degradation of targeted RNA and thus provides a tremendous opportunity for development of oligonucleotide-based drugs. Here, we report on t
Externí odkaz:
https://doaj.org/article/2d8284e76fa842139e77e268cae85b46
Autor:
Ganesh Selvaraj Duraisamy, Eunji Jo, Ivana Huvarová, Kyu-Ho P. Park, Zbyněk Heger, Vojtěch Adam, Daniel Růžek, Marc P. Windisch, Andrew D. Miller
Publikováno v:
Heliyon, Vol 8, Iss 9, Pp e10465- (2022)
Ginsenosides are a class of natural steroid glycosides and triterpene saponins found in Panax ginseng. After screening of a commercial ginsenoside compound library for low cellular cytotoxicity and the ability to mediate efficient reductions in hepat
Externí odkaz:
https://doaj.org/article/a8de4d1d5ad84c698c444ee4e38e4f30
Autor:
Mariano Genera, Barbara Quioc-Salomon, Antonin Nourisson, Baptiste Colcombet-Cazenave, Ahmed Haouz, Ariel Mechaly, Mariette Matondo, Magalie Duchateau, Alexander König, Marc P. Windisch, Christine Neuveut, Nicolas Wolff, Célia Caillet-Saguy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Interactions between the hepatitis B virus core protein (HBc) and host cell proteins are poorly understood, although they may be essential for the propagation of the virus and its pathogenicity. HBc has a C-terminal PDZ (PSD-95, Dlg1, ZO-1)-
Externí odkaz:
https://doaj.org/article/1aa13d44608f4a1a8117b0820723178a
Autor:
Jaewon Yang, Alexander König, Soonju Park, Eunji Jo, Pil Soo Sung, Seung Kew Yoon, Eva Zusinaite, Denis Kainov, David Shum, Marc Peter Windisch
Publikováno v:
JHEP Reports, Vol 3, Iss 4, Pp 100296- (2021)
Background & Aims: Chronic hepatitis B is an incurable disease. Addressing the unmet medical need for therapies has been hampered by a lack of suitable cell culture models to investigate the HBV life cycle in a single experimental setup. We sought to
Externí odkaz:
https://doaj.org/article/1e0390c1447c43c2833a8a97f1de481f
Autor:
Aleksandr Ianevski, Rouan Yao, Eva Zusinaite, Laura Sandra Lello, Sainan Wang, Eunji Jo, Jaewon Yang, Erlend Ravlo, Wei Wang, Hilde Lysvand, Kirsti Løseth, Valentyn Oksenych, Tanel Tenson, Marc P. Windisch, Minna M. Poranen, Anni I. Nieminen, Svein Arne Nordbø, Mona Høysæter Fenstad, Gunnveig Grødeland, Pål Aukrust, Marius Trøseid, Anu Kantele, Eglė Lastauskienė, Astra Vitkauskienė, Nicolas Legrand, Andres Merits, Magnar Bjørås, Denis E. Kainov
Publikováno v:
Viruses, Vol 13, Iss 12, p 2489 (2021)
Background: There is an urgent need for new antivirals with powerful therapeutic potential and tolerable side effects. Methods: Here, we tested the antiviral properties of interferons (IFNs), alone and with other drugs in vitro. Results: While IFNs a
Externí odkaz:
https://doaj.org/article/fdd3427c779b42a5b595834a986d6d6d
Autor:
Meehyun Ko, So Young Chang, Soo Young Byun, Aleksandr Ianevski, Inhee Choi, Anne-Laure Pham Hung d’Alexandry d’Orengiani, Erlend Ravlo, Wei Wang, Magnar Bjørås, Denis E. Kainov, David Shum, Ji-Young Min, Marc P. Windisch
Publikováno v:
Viruses, Vol 13, Iss 4, p 651 (2021)
Therapeutic options for coronaviruses remain limited. To address this unmet medical need, we screened 5406 compounds, including United States Food and Drug Administration (FDA)-approved drugs and bioactives, for activity against a South Korean Middle
Externí odkaz:
https://doaj.org/article/f21ab46b682142fdb986507f13718ee8
Publikováno v:
BioTechniques, Vol 59, Iss 5, Pp 287-293 (2015)
After encapsidation, where pregenomic RNA (pgRNA) is packaged into viral nucleocapsids, hepatitis B virus (HBV) uses the pgRNA as a template to replicate its DNA genome by reverse transcription. To date, there are only two encapsidation detection met
Externí odkaz:
https://doaj.org/article/bf63f10c92c34c44af9a4a84d3cf0f98
Autor:
Marc P. Windisch, Soumaya Benjelloun, Jalal Nourlil, Wahiba Ezzemani, Haya Altawalah, Sayeh Ezzikouri, Anass Kettani
Publikováno v:
Infectious Disorders - Drug Targets. 21:572-581
Background:Globally, the recent outbreak of Zika virus (ZIKV) in Brazil, Asia Pacific, and other countries highlighted the unmet medical needs. Currently, there are neither effective vaccines nor therapeutics available to prevent or treat ZIKV infect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6042709f02ae17e9c3aaee067bdf3b5
https://doi.org/10.2174/1871526520666200810153657
https://doi.org/10.2174/1871526520666200810153657
Autor:
Eun Kyu Lee, Tae Kon Kim, Inhee Choi, Hyung Chul Ryu, Marc P. Windisch, Jee Woong Lim, Hye Hyun Yoo
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 462-468 (2021)
To develop unique small-molecule inhibitors of hepatitis C virus (HCV), thiophen urea (TU) derivatives were synthesised and screened for HCV entry inhibitory activities. Among them, seven TU compounds exhibited portent anti-viral activities against g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb6284ec1aaa1ade7fe5f91d7965901
https://doaj.org/article/f0c396f876fc46c69ff6a4c1280f3573
https://doaj.org/article/f0c396f876fc46c69ff6a4c1280f3573
Structure-guided discovery approach identifies potential lead compounds targeting Mpro of SARS-CoV-2
Autor:
Kuldeep Dhama, Anass Kettani, Marc P. Windisch, Sayeh Ezzikouri, Jalal Nourlil, Soumaya Benjelloun, Yashpal Singh Malik, Michinori Kohara, Kyoko Tsukiyama-Kohara, Mohcine Elmessaoudi-Idrissi
Publikováno v:
VirusDisease
The ongoing coronavirus disease 19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become fatal for the world with affected population crossing over 25 million in more than 217 countries, consequently declared a global
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433ac7659b40aff296904c9c414d66f3
https://doi.org/10.1007/s13337-020-00627-6
https://doi.org/10.1007/s13337-020-00627-6