Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Marc P M, Soutar"'
Autor:
Capucine de Talhouët, Noemi Esteras, Marc P. M. Soutar, Benjamin O’Callaghan, Helene Plun-Favreau
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract It has recently been shown that KAT8, a genome-wide association study candidate risk gene for Parkinson’s Disease, is involved in PINK1/Parkin-dependant mitophagy. The KAT8 gene encodes a lysine acetyltransferase and represents the catalyt
Externí odkaz:
https://doaj.org/article/cd12b487421943daa9612241182f2776
Autor:
Marc P M Soutar, Daniela Melandri, Benjamin O’Callaghan, Emily Annuario, Amy E Monaghan, Natalie J Welsh, Karishma D’Sa, Sebastian Guelfi, David Zhang, Alan Pittman, Daniah Trabzuni, Anouk H A Verboven, Kylie S Pan, Demis A Kia, Magda Bictash, Sonia Gandhi, Henry Houlden, Mark R Cookson, Nael Nadif Kasri, Nicholas W Wood, Andrew B Singleton, John Hardy, Paul J Whiting, Cornelis Blauwendraat, Alexander J Whitworth, Claudia Manzoni, Mina Ryten, Patrick A Lewis, Hélène Plun-Favreau
Publikováno v:
Brain. 145:4349-4367
Parkinson's disease is a common incurable neurodegenerative disease. The identification of genetic variants via genome-wide association studies has considerably advanced our understanding of the Parkinson's disease genetic risk. Understanding the fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12f2a7e7a1bd11cd4fd4af51e6ec49d
https://doi.org/10.1093/brain/awac325
https://doi.org/10.1093/brain/awac325
Autor:
Marc P. M. Soutar, Liam Kempthorne, Shuichi Miyakawa, Emily Annuario, Daniela Melandri, Jasmine Harley, Gregory A. O’Sullivan, Selina Wray, David C. Hancock, Mark R. Cookson, Julian Downward, Mark Carlton, Hélène Plun-Favreau
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
The discovery of mutations within genes associated with autosomal recessive Parkinson’s disease allowed for the identification of PINK1/Parkin regulated mitophagy as an important pathway for the removal of damaged mitochondria. While recent studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fe52e5cac98c1d66f084232f431d7850
https://pubmed.ncbi.nlm.nih.gov/29891871
https://pubmed.ncbi.nlm.nih.gov/29891871
Autor:
Claudia Manzoni, Adamantios Mamais, Dorien A. Roosen, Sybille Dihanich, Marc P. M. Soutar, Helene Plun-Favreau, Rina Bandopadhyay, John Hardy, Sharon A. Tooze, Mark R. Cookson, Patrick A. Lewis
Leucine rich repeat kinase 2 is a complex enzyme with both kinase and GTPase activities, closely\ud linked to the pathogenesis of several human disorders including Parkinson’s disease, Crohn’s\ud disease, leprosy and cancer. LRRK2 has been implic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6fd6959c91e103ff3444b54adc410fc3
https://centaur.reading.ac.uk/67483/1/srep35106.pdf
https://centaur.reading.ac.uk/67483/1/srep35106.pdf
Autor:
Marc P M, Soutar, Woo-Yang, Kim, Ritchie, Williamson, Mark, Peggie, Charles James, Hastie, Hilary, McLauchlan, William D, Snider, Phillip R, Gordon-Weeks, Calum, Sutherland
Publikováno v:
Journal of neurochemistry. 115(4)
Mammalian glycogen synthase kinase-3 (GSK3) is generated from two genes, GSK3α and GSK3β, while a splice variant of GSK3β (GSK3β2), containing a 13 amino acid insert, is enriched in neurons. GSK3α and GSK3β deletions generate distinct phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad0bc15bd9761f5f58e544a485eb7bc0
https://pubmed.ncbi.nlm.nih.gov/20831597
https://pubmed.ncbi.nlm.nih.gov/20831597