Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Marc N. Mathieu"'
1
Solid-phase synthesis of benzimidazole N-oxides on SynPhase™ Lanterns
Autor: Zemin Wu, Nicholas J. Ede, Marc N. Mathieu
Publikováno v: Tetrahedron Letters. 44:2293-2296
A solid-phase synthesis of benzimidazole N -oxides was developed while attempting to synthesize 1,5-benzodiazepine-2,4-diones. The key step of the synthesis involves the reduction of an arylnitro to a hydroxyamino intermediate which subsequently cond
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::986abd6c1518847ed9b13476ece3aa7e
https://doi.org/10.1016/s0040-4039(03)00275-2
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2
Synthesis of Tetrahydro-1,4-Benzodiazepine-2-ones on Hydrophilic Polyamide SynPhase Lanterns
Autor: Michael C. Fitzgerald, Rhonda Campbell, Phil Riley, Nicholas J. Ede, Francesca Ercole, K. R. A. Samankumara Sandanayake, Zemin Wu, Senake Perera, Philip Rea, and Andrew M. Bray, Marc N. Mathieu, Yen Pham
Publikováno v: Journal of Combinatorial Chemistry. 5:166-171
Solid-phase synthesis is greatly dependent on the solid support. Here, we report the use of a new hydrophilic grafted surface on SynPhase lanterns in solid-phase organic chemistry. A convenient and facile solid-phase synthesis of disubstituted 1,4-be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bec6a6cd2d73afbf099ad4e9be1184
https://doi.org/10.1021/cc020057c
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3
Synthesis, conformational studies and biological activity of Να-mono-biotinylated rat relaxin*
Autor: John D. Wade, Geoffrey W. Tregear, E.C. Nice, Roger J. Summers, Courtney Peta Bond, Bruno Catimel, Marc N. Mathieu, Laszlo Otvos
Publikováno v: The Journal of Peptide Research. 57:374-382
Biotin−avidin immobilization can be a useful tool in structure–function studies of hormone receptors. A crucial step is the preparation of a specifically biotinylated hormone that is able to bind to its receptor while leaving the biotin group fre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fc3a17651c5bbbbeb53c958107a6fa3
https://doi.org/10.1034/j.1399-3011.2001.00853.x
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4
Novel strategy for the synthesis of template-assembled analogues of rat relaxin1
Autor: Yean Yeow Tan, Marc N. Mathieu, Geoffrey W. Tregear, John D. Wade, Roger J. Summers
Publikováno v: Journal of Peptide Science. 6:235-242
The ‘template-assembled synthetic protein’ (TASP) concept provides a simple and elegant approach for the preparation of analogues that retain key structural elements. We have synthesized TASP molecules containing the putative active site of relax
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1d7728d28121ef64325e846c211c8a5
https://doi.org/10.1002/(sici)1099-1387(200005)6:5<235::aid-psc247>3.0.co
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5
Base-induced side reactions in Fmoc-solid phase peptide synthesis: Minimization by use of piperazine as Nα-deprotection reagent
Autor: Mary Macris, Geoffrey W. Tregear, John D. Wade, Marc N. Mathieu
Publikováno v: Letters in Peptide Science. 7:107-112
Base-induced aspartimide (cyclic imide) and subsequent base adduct formation in the Fmoc-solid phase synthesis of sensitive sequences are serious side reactions that are difficult to both anticipate and control. The effect of extended treatment of pi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c66e89ad81c5589609a7b26ce715b83f
https://doi.org/10.1007/bf02443569
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7
Understanding the chemistry and biology of rodent relaxin: Role of the C-peptide
Autor: Yean Yeow Tan, Geoffrey W. Tregear, Roger J. Summers, Marc N. Mathieu, John D. Wade, Mary Macris, Nicola F. Dawson
Publikováno v: Chinese Peptide Symposia ISBN: 0792362799
Relaxin, a two-chain, three disulfide-bonded member of the insulin superfamily, is produced principally by the corpus luteum of the ovary during pregnancy. It has long been considered that its primary role is that of preparing the birth tract for the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19a5a05548e06e28d88e3f7c2ef8adbc
https://doi.org/10.1007/0-306-46880-8_19
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9
Chemical synthesis of relaxin analogues: Current status and future developments
Autor: John D. Wade, Kathryn J. Smith, Antonia A. Claasz, Ping Fu, Andrew B. Clippingdale, Marc N. Mathieu, Geoffrey W. Tregear, Nicola F. Dawson
Publikováno v: Relaxin 2000 ISBN: 9789048158454
Knowledge of the chemistry of relaxin has increased steadily since the first determination of its primary structure in the early 1970s. The two peptide chain/three disulfide bonds structure mirrors that of insulin and established the concept of the s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5eb68f104b2527b90d51b6b86e1be3b
https://doi.org/10.1007/978-94-017-2877-5_35
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10
Design and Synthesis of a Mini-Prorelaxin Model
Autor: Geoffrey W. Tregear, Marc N. Mathieu, Nicola F. Dawson, John D. Wade
Publikováno v: Peptides: The Wave of the Future ISBN: 9789401039055
Relaxin is a two-chain peptide that shares several common features with insulin, such as size, chain structure and the cross-linking pattern. It is produced principally by the ovaries during pregnancy and has three major biological effects: (1) it de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::815c1ea9cef03bc8a98b67db523aa1e0
https://doi.org/10.1007/978-94-010-0464-0_207
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