Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Marc N. Hirt"'
Autor:
Benjamin Kloth, Giulia Mearini, Florian Weinberger, Justus Stenzig, Birgit Geertz, Jutta Starbatty, Diana Lindner, Udo Schumacher, Hermann Reichenspurner, Thomas Eschenhagen, Marc N. Hirt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract A short-term increase in ventricular filling leads to an immediate (Frank-Starling mechanism) and a slower (Anrep effect) rise in cardiac contractility, while long-term increased cardiac load (e.g., in arterial hypertension) decreases contra
Externí odkaz:
https://doaj.org/article/e97f01fb532e4bb386845e9e151fa9b8
Autor:
Maximillian Fischer, Moritz Jakab, Marc N. Hirt, Tessa R. Werner, Stefan Engelhardt, Antonio Sarikas
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Cullin-RING ubiquitin ligases (CRL) regulate numerous biological processes in the heart and have been implicated in regulating cardiac hypertrophy. This study aimed to identify novel hypertrophy-modulating CRLs in cardiomyocytes (CM). A functional ge
Externí odkaz:
https://doaj.org/article/9ab662ddb713488bb5c37af7395bd7e5
Autor:
D. Julia Trembinski, Diewertje I. Bink, Kosta Theodorou, Janina Sommer, Ariane Fischer, Anke van Bergen, Chao-Chung Kuo, Ivan G. Costa, Christoph Schürmann, Matthias S. Leisegang, Ralf P. Brandes, Tijna Alekseeva, Boris Brill, Astrid Wietelmann, Christopher N. Johnson, Alexander Spring-Connell, Manuel Kaulich, Stanislas Werfel, Stefan Engelhardt, Marc N. Hirt, Kaja Yorgan, Thomas Eschenhagen, Luisa Kirchhof, Patrick Hofmann, Nicolas Jaé, Ilka Wittig, Nazha Hamdani, Corinne Bischof, Jaya Krishnan, Riekelt H. Houtkooper, Stefanie Dimmeler, Reinier A. Boon
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Aging induces cardiovascular disease, but which RNA molecules control cardiac aging is poorly understood. Here the authors identified the aging-regulated non-coding RNA Sarrah, which controls cardiomyocyte survival and cardiac function by inducing ca
Externí odkaz:
https://doaj.org/article/7441973a82494a94a2d3de6efa08b38c
Autor:
Franziska Kenneweg, Claudia Bang, Ke Xiao, Chantal M. Boulanger, Xavier Loyer, Stephane Mazlan, Blanche Schroen, Steffie Hermans-Beijnsberger, Ariana Foinquinos, Marc N. Hirt, Thomas Eschenhagen, Sandra Funcke, Stevan Stojanovic, Celina Genschel, Katharina Schimmel, Annette Just, Angelika Pfanne, Kristian Scherf, Susann Dehmel, Stella M. Raemon-Buettner, Jan Fiedler, Thomas Thum
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 363-374 (2019)
Long non-coding RNAs (lncRNAs) have potential as novel therapeutic targets in cardiovascular diseases, but detailed information about the intercellular lncRNA shuttling mechanisms in the heart is lacking. Here, we report an important novel crosstalk
Externí odkaz:
https://doaj.org/article/082462a5ca7046e4a3a1e853a2b8ca0e
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Afterload enhancement (AE) of rat engineered heart tissue (EHT) in vitro leads to a multitude of changes that in vivo are referred to as pathological cardiac hypertrophy: e.g., cardiomyocyte hypertrophy, contractile dysfunction, reactivation
Externí odkaz:
https://doaj.org/article/0fa1711dc2dc4da28a62e632b28a965e
Autor:
Michaela Schäfer, Christian U. Oeing, Maria Rohm, Ezgi Baysal-Temel, Lorenz H. Lehmann, Ralf Bauer, H. Christian Volz, Michael Boutros, Daniela Sohn, Carsten Sticht, Norbert Gretz, Katrin Eichelbaum, Tessa Werner, Marc N. Hirt, Thomas Eschenhagen, Karin Müller-Decker, Oliver Strobel, Thilo Hackert, Jeroen Krijgsveld, Hugo A. Katus, Mauricio Berriel Diaz, Johannes Backs, Stephan Herzig
Publikováno v:
Molecular Metabolism, Vol 35, Iss , Pp - (2020)
Externí odkaz:
https://doaj.org/article/ea76deb615ca4c0d9e6c97a62a0ed7ec
Autor:
Marc D. Lemoine, Ingra Mannhardt, Kaja Breckwoldt, Maksymilian Prondzynski, Frederik Flenner, Bärbel Ulmer, Marc N. Hirt, Christiane Neuber, András Horváth, Benjamin Kloth, Hermann Reichenspurner, Stephan Willems, Arne Hansen, Thomas Eschenhagen, Torsten Christ
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising tool for drug testing and modelling genetic disorders. Abnormally low upstroke velocity is a current limitation. Here we investigated the use of 3D enginee
Externí odkaz:
https://doaj.org/article/2e69ee578b0a4779a389e8f3a0ff7687
Autor:
Ingra Mannhardt, Kaja Breckwoldt, David Letuffe-Brenière, Sebastian Schaaf, Herbert Schulz, Christiane Neuber, Anika Benzin, Tessa Werner, Alexandra Eder, Thomas Schulze, Birgit Klampe, Torsten Christ, Marc N. Hirt, Norbert Huebner, Alessandra Moretti, Thomas Eschenhagen, Arne Hansen
Publikováno v:
Stem Cell Reports, Vol 7, Iss 1, Pp 29-42 (2016)
Analyzing contractile force, the most important and best understood function of cardiomyocytes in vivo is not established in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM). This study describes the generation of 3D, strip-forma
Externí odkaz:
https://doaj.org/article/b1daac147592484a98d637f6bdda35b3
Autor:
Michaela Schäfer, Christian U. Oeing, Maria Rohm, Ezgi Baysal-Temel, Lorenz H. Lehmann, Ralf Bauer, H. Christian Volz, Michael Boutros, Daniela Sohn, Carsten Sticht, Norbert Gretz, Katrin Eichelbaum, Tessa Werner, Marc N. Hirt, Thomas Eschenhagen, Karin Müller-Decker, Oliver Strobel, Thilo Hackert, Jeroen Krijgsveld, Hugo A. Katus, Mauricio Berriel Diaz, Johannes Backs, Stephan Herzig
Publikováno v:
Molecular Metabolism, Vol 5, Iss 2, Pp 67-78 (2016)
Objectives: Cancer cachexia affects the majority of tumor patients and significantly contributes to high mortality rates in these subjects. Despite its clinical importance, the identity of tumor-borne signals and their impact on specific peripheral o
Externí odkaz:
https://doaj.org/article/b5837ba8229f44a0ac946a52d475155d
Autor:
Sandra Funcke, Tessa R. Werner, Marc Hein, Bärbel M. Ulmer, Arne Hansen, Thomas Eschenhagen, Marc N. Hirt
Publikováno v:
Biomolecules, Vol 10, Iss 9, p 1309 (2020)
Intermittent hypoxia and various pharmacological compounds protect the heart from ischemia reperfusion injury in experimental approaches, but the translation into clinical trials has largely failed. One reason may lie in species differences and the l
Externí odkaz:
https://doaj.org/article/e0b3e8886c6e422aab5e125231a682ab