Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer

Autor: Marc Núnez-Ollé, Jan Trka, Bora Gurel, Jesús M. Paramio, Ana R. Cortazar, Juana M. Flores, Ivana Hermanova, Alfredo Caro-Maldonado, Johann S. de Bono, Roger R. Gomis, Suzanne Carreira, Verónica Torrano, Patricia Zúñiga-García, Antonio Gómez-Muñoz, Fernando Salvador, Cristian Suárez-Cabrera, Rosa Barrio, Guillermo Velasco, Mar Lorente, Iris Lodewijk, Natalia Martín-Martín, José I. López, Sonia Fernández-Ruiz, Arkaitz Carracedo, Amaia Arruabarrena-Aristorena, Marc Guiu, Ianire Astobiza, Amaia Zabala-Letona, James D. Sutherland, Laura Camacho, Lorea Valcarcel-Jimenez, Anabel Martinez-Romero, Jose M. Lizcano, Mariona Graupera, Ana Talamillo

Publikováno v: Journal of Experimental Medicine
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
E-Prints Complutense. Archivo Institucional de la UCM
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
The Journal of Experimental Medicine

This study unravels an unprecedented murine model of lethal metastatic prostate cancer, based on the combined deletion of Pten and Lkb1. Importantly, minimal activity of LKB1 is sufficient to hamper prostate cancer cell aggressiveness, thus redefinin

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