Thyroid hormone improves postischaemic recovery of function while limiting apoptosis: a new therapeutic approach to support hemodynamics in the setting of ischaemia-reperfusion?

Autor: Constantinos Pantos, Iordanis Mourouzis, Philipos Perimenis, Marc Massonneau, D. Spanou, Dennis V. Cokkinos, Heidi Ligeret, Pauline Noack-Fraissignes, Georgia Kostopanagiotou, Theodosios Saranteas, Pierre-Yves Renard, Guillaume Clavé

Publikováno v: Basic Research in Cardiology. 104:69-77

Although it has long been recognized that thyroid hormone is an effective positive inotrope, its efficacy in supporting hemodynamics in the acute setting of ischaemia and reperfusion (R) without worsening reperfusion injury remains largely unknown. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3b6899247b2b54bd78b14461d3a595
https://doi.org/10.1007/s00395-008-0758-4

Latent Fluorophores Based on a Self-Immolative Linker Strategy and Suitable for Protease Sensing

Autor: Valérie Jolivel, Raphaël Dumeunier, Anthony Romieu, David Vaudry, Pierre-Yves Renard, Yves Meyer, Jean-Alexandre Richard, Hubert Vaudry, Marc Massonneau

Publikováno v: Bioconjugate Chemistry. 19:1707-1718

The self-immolative spacer para-aminobenzyl alcohol (PABA) was used as a key component in the design of new protease-sensitive fluorogenic probes whose parent phenol-based fluorophore is released through an enzyme-initiated domino reaction. First, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad1a4b40f2d1b9be7d8be0d8619d3b4
https://doi.org/10.1021/bc8001997

Synthesis and post-synthetic derivatization of a cyanine-based amino acid. Application to the preparation of a novel water-soluble NIR dye

Autor: Marc Massonneau, Bertrand Chipon, Cédric Bouteiller, Pierre-Yves Renard, Guillaume Clavé, Anthony Romieu

Publikováno v: Tetrahedron Letters. 47:8279-8284

An efficient synthesis of a new fluorescent amino acid derived from a pentamethylene cyanine dye is described. Selective derivatization of its amino group with an original trisulfonated linker has led to a novel water-soluble NIR dye suitable for cov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40fefca6b1728201480d853a71ebb5a1
https://doi.org/10.1016/j.tetlet.2006.09.100

Biochemical Characterization of a Caspase-3 Far-red Fluorescent Probe for Non-invasive Optical Imaging of Neuronal Apoptosis

Autor: Valérie Jolivel, Alain Fournier, Pierre-Yves Renard, Jérôme Leprince, Béatrice Botia, Heidi Ligeret, Omar Touzani, Hubert Vaudry, Bruno Delest, Anthony Romieu, David Vaudry, Marc Massonneau, Sébastien Arthaud, Pauline Noack, Christophe Portal, Guillaume Clavé

Publikováno v: Journal of Molecular Neuroscience
Journal of Molecular Neuroscience, 2014, 54 (3), pp.451-462. ⟨10.1007/s12031-014-0325-4⟩
Journal of Molecular Neuroscience, Humana Press, 2014, 54 (3), pp.451-462. ⟨10.1007/s12031-014-0325-4⟩

International audience; Apoptosis is a regulated process, leading to cell death, which is involved in several pathologies including neurodegenerative diseases and stroke. Caspase-3 is a key enzyme of the apoptotic pathway and is considered as a major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e1bc5c9259425a61d1d3166ad9961d
https://hal.science/hal-01196843

Chemiluminescent Probe for the in Vitro Detection of Protease Activity

Autor: Jean-Alexandre Richard, Ludovic Jean, Pauline Noack-Fraissignes, Anthony Romieu, Marc Massonneau, Pierre-Yves Renard

Publikováno v: Organic Letters. 9:4853-4855

A strategy involving the use of a self-immolative linker has been investigated for the chemiluminescent sensing of proteases. The reactive linker enabled the release of a 1,2-dioxetane light precursor. As a proof of principle, caspase-3, a key peptid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790127c728c74b2b0e4d8be457c2638b
https://doi.org/10.1021/ol702190y