Výsledky vyhledávání

Effects of dimethylaminoethanol pyroglutamate (DMAE p-Glu) against memory deficits induced by scopolamine: evidence from preclinical and clinical studies

Autor: Jacky Tisne-Versailles, Pierre Sokoloff, Olivier Blin, Catherine Cassé-Perrot, Arthur Kaladjian, Mohammed Zaim, Christine Audebert, Marc Marien, Philippe Chopin, Severine Pitel, Joëlle Micallef

Publikováno v: Psychopharmacology. 207:201-212

Dimethylaminoethanol pyroglutamate (DMAE p-Glu) is a compound resulting from the reaction between dimethylaminoethanol (an indirect precursor of acetylcholine) and pyroglutamic acid (a cyclic derivative of glutamic acid having procholinergic properti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc464a346912ac253ed86cd6fa04f39
https://doi.org/10.1007/s00213-009-1648-7

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Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid

Autor: Françoise Saurini, Pierre Sokoloff, Serge Guerreiro, Etienne C. Hirsch, Patrick P. Michel, Daniel Alvarez-Fischer, Andreas Hartmann, Stéphane Hunot, Marc Marien

Publikováno v: Journal of Neurochemistry. 107:701-711

Mouse models of MPTP intoxication have been used extensively to explore the molecular mechanisms of Parkinson's disease. However, these models present some limitations since; (i) Dopaminergic (DA) cell death occurs rapidly in contrast to the presumab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d688c9cdcf5d5e19976d93174855be1e
https://doi.org/10.1111/j.1471-4159.2008.05651.x

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Novelty Determines the Effects of Olfactory Enrichment on Memory and Neurogenesis Through Noradrenergic Mechanisms

Autor: Véronique Nguyen, Joëlle Sacquet, Marc Marien, François Jourdan, Alexandra Veyrac, Anne Didier

Publikováno v: Neuropsychopharmacology. 34:786-795

Commonly used experimental paradigms of environmental enrichment combine increased social interactions and sensory inputs and renewal of the objects present in the environment. However, the specific contribution of novelty to the effects of enrichmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d02b55f773a89beb65b139377dbbfc6
https://doi.org/10.1038/npp.2008.191

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Noradrenaline provides long-term protection to dopaminergic neurons by reducing oxidative stress

Autor: Frédéric Darios, Andreas Hartmann, Merle Ruberg, Patrick P. Michel, Francis Colpaert, Jean-Denis Troadec, Marc Marien

Publikováno v: Journal of Neurochemistry. 79:200-210

To better understand the neurotrophic function of the neurotransmitter noradrenaline, we have developed a model of mesencephalic cultures in which we find low concentrations (0.3-10 microM) of noradrenaline to be remarkably effective in promoting lon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e4635769cfb52c76a02ffba90a932e6
https://doi.org/10.1046/j.1471-4159.2001.00556.x

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Noradrenergic control of odor recognition in a nonassociative olfactory learning task in the mouse

Autor: Véronique Nguyen, François Jourdan, Alexandra Veyrac, Marc Marien, Anne Didier

Publikováno v: Learning & Memory. 14:847-854

The present study examined the influence of pharmacological modulations of the locus coeruleus noradrenergic system on odor recognition in the mouse. Mice exposed to a nonrewarded olfactory stimulation (training) were able to memorize this odor and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8bcaa04e0033cb0773a93c606723c3
https://doi.org/10.1101/lm.708807

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Extracellular Hippocampal Acetylcholine Level Controls Amygdala Function and Promotes Adaptive Conditioned Emotional Response

Autor: Jacques Micheau, Robert Jaffard, Aline Desmedt, Ludovic Calandreau, Pierre Trifilieff, Marc Marien, Nicole Mons, Aline Marighetto, Laurence Costes

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2006, 26 (52), pp.13556-13566. ⟨10.1523/JNEUROSCI.3713-06.2006⟩

Ample data indicate that tone and contextual fear conditioning differentially require the amygdala and the hippocampus. However, mechanisms subserving the adaptive selection among environmental stimuli (discrete tone vs context) of those that best pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d465ff076046ac90e91a39dd8b0de736
https://doi.org/10.1523/jneurosci.3713-06.2006

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The Neurotransmitter Noradrenaline Rescues Septal Cholinergic Neurons in Culture from Degeneration Caused by Low-Level Oxidative Stress

Autor: Patrick P. Michel, Sabine Traver, Francis Colpaert, Marc Marien, Bénédicte Salthun-Lassalle, Etienne C. Hirsch

Publikováno v: Molecular Pharmacology. 67:1882-1891

We have developed a model system in which rat basal forebrain cholinergic neurons degenerate progressively when maintained in culture conditions that make them susceptible to low-level oxidative stress. In this study, we showed that cholinergic neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b657f2c57b8dbded731f93b4264cbcc3
https://doi.org/10.1124/mol.104.007864

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Noradrenergic mechanisms in neurodegenerative diseases: a theory

Autor: Francis Colpaert, Alan C. Rosenquist, Marc Marien

Publikováno v: Brain Research Reviews. 45:38-78

A deficiency in the noradrenergic system of the brain, originating largely from cells in the locus coeruleus (LC), is theorized to play a critical role in the progression of a family of neurodegenerative disorders that includes Parkinson's disease (P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a970e102e406ce592e56344d62681468
https://doi.org/10.1016/j.brainresrev.2004.02.002

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Progressive sensorimotor impairment is not associated with reduced dopamine and high energy phosphate donors in a model of ataxia-telangiectasia

Autor: Cristina Cosi, Yingji Wu, Jean-Claude Martel, Paul Fluit, Howard T.J. Mount, Eleanor Gallo-Hendrikx, Marc Marien

Publikováno v: Journal of Neurochemistry. 88:1449-1454

Ataxia-telangiectasia (A-T) is a genetic disease, associated with progressive motor impairment and a lack of functional ATM protein. It has been reported that immunoreactive tyrosine hydroxylase and dopamine transporter are reduced in an Atm-/- mouse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e8a5fae214f64d59841cc17890eaced
https://doi.org/10.1046/j.1471-4159.2003.02278.x

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Stimulation of postsynaptic α1b- and α2-adrenergic receptors amplifies dopamine-mediated locomotor activity in both rats and mice

Autor: Jean-Charles Bizot, Anne-Sophie Villégier, Candice Drouin, Marc Marien, Jean-Pol Tassin, Jacques Glowinski, Francis Colpaert

Publikováno v: Synapse. 50:277-284

Recent experiments have shown that mice lacking the alpha1b-adrenergic receptor (alpha1b-AR KO) are less responsive to the locomotor hyperactivity induced by psychostimulants, such as D-amphetamine or cocaine, than their wild-type littermates (WT). T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7217af342af0177e3f84e7e3013baf91
https://doi.org/10.1002/syn.10267

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