Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Marc M Kurtz"'
Autor:
Eric S Muise, Hong-Ping Guan, Jinqi Liu, Andrea R Nawrocki, Xiaodong Yang, Chuanlin Wang, Carlos G Rodríguez, Dan Zhou, Judith N Gorski, Marc M Kurtz, Danqing Feng, Kenneth J Leavitt, Lan Wei, Robert R Wilkening, James M Apgar, Shiyao Xu, Ku Lu, Wen Feng, Ying Li, Huaibing He, Stephen F Previs, Xiaolan Shen, Margaret van Heek, Sandra C Souza, Mark J Rosenbach, Tesfaye Biftu, Mark D Erion, David E Kelley, Daniel M Kemp, Robert W Myers, Iyassu K Sebhat
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211568 (2019)
Physical activity promotes metabolic and cardiovascular health benefits that derive in part from the transcriptional responses to exercise that occur within skeletal muscle and other organs. There is interest in discovering a pharmacologic exercise m
Externí odkaz:
https://doaj.org/article/f28b2c263a184739b47d79a0d7b9272a
Autor:
F. Anthony Romero, Robert W. Myers, Hong-Ping Guan, Anantha Gollapudi, Gaochao Zhou, Ku Lu, James F. Dropinski, Marc M. Kurtz, Xiaodong Yang, Cai Li, Iyassu K. Sebhat, Tesfaye Biftu, Danqing Feng, Ahmet Kekec, Ann E. Weber, Qing Shao, Daniel M. Kemp, Andrew Kassick, Shiyao Xu, Maria E. Trujillo
Publikováno v:
ACS Medicinal Chemistry Letters. 9:39-44
5'-Adenosine monophosphate-activated protein kinase (AMPK) is a key regulator of mammalian energy homeostasis and has been implicated in mediating many of the beneficial effects of exercise and weight loss including lipid and glucose trafficking. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523ed2d42da00835ac297ba9e01c4ffe
https://doi.org/10.1021/acsmedchemlett.7b00417
https://doi.org/10.1021/acsmedchemlett.7b00417
Autor:
Hong-Ping Guan, Wen Feng, Daniel M. Kemp, Judith N. Gorski, Shiyao Xu, Ying Li, Dan Zhou, Ku Lu, Tesfaye Biftu, David E. Kelley, Chuanlin Wang, Sandra C. Souza, Lan Wei, Danqing Feng, Robert R. Wilkening, Andrea R. Nawrocki, Iyassu K. Sebhat, Mark J. Rosenbach, Margaret van Heek, Carlos G. Rodriguez, Eric S. Muise, Xiaodong Yang, Mark D. Erion, Jinqi Liu, Stephen F. Previs, James M. Apgar, Marc M. Kurtz, Huaibing He, Robert W. Myers, Xiaolan Shen, Kenneth J. Leavitt
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211568 (2019)
PLoS ONE
PLoS ONE
Physical activity promotes metabolic and cardiovascular health benefits that derive in part from the transcriptional responses to exercise that occur within skeletal muscle and other organs. There is interest in discovering a pharmacologic exercise m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e74f669b91225dbd7a81a386f22662b
https://doaj.org/article/f28b2c263a184739b47d79a0d7b9272a
https://doaj.org/article/f28b2c263a184739b47d79a0d7b9272a
Autor:
Aleksandr Petrov, Wen Feng, Ann E. Weber, Effie Tozzo, Lisa LaFranco Scheuch, Shiyao Xu, Wei Zhu, Nancy A. Thornberry, Dinko Gonzalez Trotter, Rory J. Rohm, Franklin Liu, Ku Lu, Michelle Bunzel, David E. Kelley, Stacey Conarello, Jinqi Liu, Corin O. Miller, Xiaoda Niu, Huaibing He, Ronald E. Painter, Ying Li, Daniel M. Kemp, Ying Qian, Maria E. Trujillo, Mark D. Erion, Liyang Wang, Iyassu K. Sebhat, Gaochao Zhou, Michael Klimas, Marie A. Holahan, Marc M. Kurtz, George J. Eiermann, Guillermo Fernandez, Bindu Bennet, Juliann Ehrhart, Tesfaye Biftu, Aimie Ogawa, Sandra C. Souza, Cai Li, Srinivasa Prahalada, James A. Milligan, Hong-Ping Guan, Danqing Feng, Robert W. Myers, Douglas Wisniewski, Xiaodong Yang, Daniel Rubins, Hongwu Wang, Margaret van Heek
Publikováno v:
Science (New York, N.Y.). 357(6350)
Hitting a dozen enzymes with one drug The adenosine monophosphate-activated protein kinase (AMPK) controls cellular energy status. AMPK is activated when energy levels fall. This stimulates adenosine triphosphate (ATP)-generating pathways that promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2391508ed314a4efb53e289ff8766448
https://pubmed.ncbi.nlm.nih.gov/28774917
https://pubmed.ncbi.nlm.nih.gov/28774917
Autor:
Sony Agrawal, Marc M. Kurtz, Serena Xu, Artjohn Villafania, David Pechter, Steven Williams, Lisa M. Sonatore
Publikováno v:
Journal of laboratory automation. 21(6)
The pace and complexity of modern drug discovery places ever-increasing demands on scientists for data analysis and interpretation. Data flow programming and modern visualization tools address these demands directly. Three different requirements-one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e07fab01ffcdcbf94ced2c93c1f2f87
https://pubmed.ncbi.nlm.nih.gov/26846143
https://pubmed.ncbi.nlm.nih.gov/26846143
Autor:
Wai-Si Eng, Xinchun Tong, Richard Tschirret-Guth, Song Zheng, Gary G. Chicchi, Geoge A. Doss, Koppara Samuel, Richard Hargreaves, Terence G. Hamill, Marc M. Kurtz, Robert J. DeVita, Sanjeev Kumar, Alan Wheeldon, Emma J. Carlson, Alana Upthagrove, Jaime Lynn Bunda, Stephen Krause, Jinlong Jiang, Christine Ryan, Sander G. Mills, Donald Burns, Kwei-Lan C. Tsao
Publikováno v:
Journal of Medicinal Chemistry. 52:3039-3046
3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-4-(4-fluorophenyl)octahydro-2H-isoindol-2-yl]cyclopent-2-en-1-one (17) is a high affinity, brain-penetrant, hydroisoindoline-based neurokinin-1 (NK(1)) receptor antagonist with a lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21762545018b32ec2dc16a2b6444d66
https://doi.org/10.1021/jm8016514
https://doi.org/10.1021/jm8016514
Autor:
Janusz Jozef Kulagowski, Gary G. Chicchi, Clare London, Alan Wheeldon, Ian Thomas Huscroft, Emma J. Carlson, Marc M. Kurtz, Piotr Raubo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2008-2012
1-Phenyl-8-azabicyclo[3.2.1]octane ethers are NK1 receptor antagonists. Substitution at the 6-exo-position led to high affinity NK1 antagonists with a prolonged duration of action in vivo. Incorporation of an α-methyl substituent in the pendent benz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93157e3f9b3b77746bfe5a3bca6ab93
https://doi.org/10.1016/j.bmcl.2005.12.069
https://doi.org/10.1016/j.bmcl.2005.12.069
Autor:
Angela Williams, Mark Peter Ridgill, Gary G. Chicchi, Christopher John Swain, Jason Matthew Elliott, Marc M. Kurtz, Nicola Szeto, Denise Morrison, Alan P. Watt, Duncan Shaw
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:3031-3034
The in vivo properties of a series of 2-arylindole NK(1) antagonists have been improved, by modification of the amide substituent. The 1-(2-methoxyphenyl)piperazine amide was identified as a major area of metabolism in the lead compound 1. Replacemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6cfac69ad17a1fce3b88a85a114564c
https://doi.org/10.1016/s0960-894x(01)00616-3
https://doi.org/10.1016/s0960-894x(01)00616-3
Autor:
Gary G. Chicchi, Mark Peter Ridgill, Gregory John Hollingworth, Angela Williams, W. Rycroft, Kwei-Lan Tsao, Christopher John Swain, Kevin Dinnell, Jason Matthew Elliott, Madhumeeta J Dhar, Marc M. Kurtz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1237-1240
Novel 2-aryl indole hNK1 receptor ligands were prepared utilising palladium cross-coupling chemistry of a late intermediate as a key step. Compounds with high hNK1 receptor binding affinity and good brain penetration (e.g., 9d) were synthesised.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3971536b0f69dcc2942374639fb05eae
https://doi.org/10.1016/s0960-894x(01)00183-4
https://doi.org/10.1016/s0960-894x(01)00183-4
Autor:
Sergei Belyakov, Judyann Wiltsie, Tesfaye Biftu, Martin L. Ogletree, Venukrishnan Komanduri, Alice Struck, Alejandro Crespo, Dale Lewis, Naresh Chidurala, Lisa M. Sonatore, Marta Arocho, Xun Shen, Timothy A. Blizzard, Sanjay K. Singh, Samarpita Debnath, Marc M. Kurtz, Basanagoud S. Patil
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(4)
Thrombin is a serine protease that plays a key role in blood clotting. Pyrrolidine 1 is a potent thrombin inhibitor discovered at Merck several years ago. Seven analogs (2-8) of 1 in which the pyrrolidine core was replaced with various heterocycles w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0f85e095bb689a559fb00825d4477b
https://pubmed.ncbi.nlm.nih.gov/24461292
https://pubmed.ncbi.nlm.nih.gov/24461292