Apoptosis Induction and DNA Interstrand Cross-Link Formation by Cytotoxictrans-[PtCl2(NH(CH3)2)(NHCH(CH3)2)]: Cross-Linking between d(G) and Complementary d(C) within Oligonucleotide Duplexes

Autor: Miguel Fuertes, Annie Schwartz, Carlos Alonso, José M. Pérez, Eva I. Montero, Carmen Navarro-Ranninger, Jean Marc Malinge, Marc Leng

Publikováno v: ChemBioChem. 3:61-67

We have investigated the cytotoxic activity, the induction of apoptosis, and the interstrand cross-linking efficiency in the A2780cisR ovarian tumor cell line, after replacement of the two NH3 nonleaving groups in trans-[PtCl2(NH3)2] (trans-DDP) by d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::493f347c6d26e5995fca101aa1b88df9
https://doi.org/10.1002/1439-7633(20020104)3:1<61::aid-cbic61>3.0.co

NMR solution structure of a DNA dodecamer containing a transplatin interstrand GN7-CN3 cross-link

Autor: Gérard Lancelot, Françoise Paquet, Marc Leng, Marc Boudvillain

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 1999, 27 (21), pp.4261-4268. ⟨10.1093/nar/27.21.4261⟩
Nucleic Acids Research, 1999, 27 (21), pp.4261-4268. ⟨10.1093/nar/27.21.4261⟩

International audience; The DNA duplex d(CTCTCG*AGTCTC)d(GAGACTC*GAGAG) containing a single trans-diammine-dichloroplatinum(ll) interstrand cross-link (where G* and C* represent the platinated bases) has been studied by two-dimensional NMR, All the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6e30015e79cc07f30d452a00bc7a30
https://doi.org/10.1093/nar/27.21.4261

HMG1 protein inhibits the translesion synthesis of the major DNA cisplatin adduct by cell extracts 1 1Edited by M. Yaniv

Autor: Daniel Locker, Giuseppe Villani, Jean-Sébastien Hoffmann, Marc Leng

Publikováno v: Journal of Molecular Biology. 270:539-543

When situated in a fork-like synthetic DNA replication substrate, the 1,2-intrastrand crosslink at the d(GpG) site, the most frequent adduct formed in the reaction between DNA and the anticancer drug cisplatin (cis-diamminedichloroplatinum (II)), is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cc2c40e200d5ed61292e021a1500ba0
https://doi.org/10.1006/jmbi.1997.1143

High resolution mapping of E.coli transcription elongation complex in situ reveals protein interactions with the non-transcribed strand

Autor: Marc Leng, Martine Guérin, A. R. Rahmouni

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 1996, 15 (19), pp.5397-5407

International audience; We have used chemical probes and UV light to perform a high resolution mapping of an Escherichia coli transcription elongation complex that was arrested in vivo by a protein readblock at a position distal to the promoter. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6cd71834cb0fbedee6407f4a1f8ee4
https://doi.org/10.1002/j.1460-2075.1996.tb00923.x

DNA double helix promotes a linkage isomerization reaction in trans-diamminedichloroplatinum(II)-modified DNA

Autor: Rozenn Dalbies, Marc Leng, Dominique Payet

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 1994, 91 (17), pp.8147-8151. ⟨10.1073/pnas.91.17.8147⟩

In the reaction between trans-diamminedichloroplatinum(II) and a single-stranded pyrimidin-rich oligodeoxyribonucleotide (22-mer) containing the central sequence TGAGT, the 1,3-trans-[Pt(NH3)2[d(GAG)]] cross-link is formed. The 1,3-intrastrand cross-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e35b1e1f362ddf55a505a92c8ee97a3
https://doi.org/10.1073/pnas.91.17.8147