Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Marc Le Vée"'
Autor:
Marie Kerhoas, Jennifer Carteret, Lilou Huchet, Elodie Jouan, Laurence Huc, Marc Le Vée, Olivier Fardel
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 276, Iss , Pp 116261- (2024)
Succinate dehydrogenase inhibitors (SDHIs) are widely-used fungicides, to which humans are exposed and for which putative health risks are of concern. In order to identify human molecular targets for these agrochemicals, the interactions of 15 SDHIs
Externí odkaz:
https://doaj.org/article/467e2f2c6165461a83f09ebcc1bea1b7
Autor:
Valentin Tastet, Marc Le Vée, Marie Kerhoas, Anna Zerdoug, Elodie Jouan, Arnaud Bruyère, Olivier Fardel
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 263, Iss , Pp 115348- (2023)
Organophosphate flame retardants (OPFRs) are environmental pollutants of increasing interest, widely distributed in the environment and exerting possible deleterious effects towards the human health. The present study investigates in vitro their poss
Externí odkaz:
https://doaj.org/article/3f0cd1b2c257427e9b55b3e02e28499a
Autor:
Solène Marie, Irene Hernández-Lozano, Marc Le Vée, Louise Breuil, Wadad Saba, Maud Goislard, Sébastien Goutal, Charles Truillet, Oliver Langer, Olivier Fardel, Nicolas Tournier
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 392 (2022)
Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which control the hepatobiliary elimination of drugs and bile acids. 99mTc-mebrofenin is a non-metabolized substrate of transporters expressed at the different poles
Externí odkaz:
https://doaj.org/article/27ee7558c859412bb9672fe2db8e091a
Autor:
Charles R. Lefèvre, Marc Le Vée, Sophie Gaubert, Elodie Jouan, Arnaud Bruyere, Caroline Moreau, Olivier Fardel
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12926 (2021)
The search of substrates for solute carriers (SLCs) constitutes a major issue, owing notably to the role played by some SLCs, such as the renal electrogenic organic cation transporter (OCT) 2 (SLC22A2), in pharmacokinetics, drug–drug interactions a
Externí odkaz:
https://doaj.org/article/bb97e73349fd4611b418ddc96879f6bd
Autor:
Abdullah Mayati, Amélie Moreau, Marc Le Vée, Bruno Stieger, Claire Denizot, Yannick Parmentier, Olivier Fardel
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 4, p 764 (2017)
Drug transporters are now recognized as major actors in pharmacokinetics, involved notably in drug–drug interactions and drug adverse effects. Factors that govern their activity, localization and expression are therefore important to consider. In t
Externí odkaz:
https://doaj.org/article/1f5ac99a766a4248a2c38965b191424a
Publikováno v:
Pharmaceutics, Vol 9, Iss 1, p 3 (2016)
Human hepatoma cells may represent a valuable alternative to the use of human hepatocytes for studying hepatic drug transporters, which is now a regulatory issue during drug development. In the present work, we have characterized hepatic drug transpo
Externí odkaz:
https://doaj.org/article/2a4ecf1f199d4d48bd1e14ff765d6499
Autor:
Elodie Jouan, Marc Le Vée, Abdullah Mayati, Claire Denizot, Yannick Parmentier, Olivier Fardel
Publikováno v:
Pharmaceutics, Vol 8, Iss 2, p 12 (2016)
In vitro evaluation of P-glycoprotein (P-gp) inhibitory potential is now a regulatory issue during drug development, in order to predict clinical inhibition of P-gp and subsequent drug–drug interactions. Assays for this purpose, commonly based on P
Externí odkaz:
https://doaj.org/article/b195d41d987e48fe8fd614d50fe54910
Autor:
David Gilot, Nolwenn Le Meur, Fanny Giudicelli, Marc Le Vée, Dominique Lagadic-Gossmann, Nathalie Théret, Olivier Fardel
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18261 (2011)
The aryl hydrocarbon receptor (AhR) is a transcription factor activated by several environmental pollutants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and involved in carcinogenesis and various physiological processes, including immune resp
Externí odkaz:
https://doaj.org/article/d9020e2943854eb18e0c9d2d57c856d3
Publikováno v:
Environmental Pollution
Environmental Pollution, 2023, 331 (Pt 2), pp.121882. ⟨10.1016/j.envpol.2023.121882⟩
Environmental Pollution, 2023, 331 (Pt 2), pp.121882. ⟨10.1016/j.envpol.2023.121882⟩
International audience; Human membrane drug transporters are recognized as major actors of pharmacokinetics; they also handle endogenous compounds, including hormones and metabolites. Chemical additives present in plastics interact with human drug tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdf64c4e888ef90cf4ebca8f2e929b2
https://hal.science/hal-04121151
https://hal.science/hal-04121151
Publikováno v:
Biopharmaceutics and Drug Disposition
Biopharmaceutics and Drug Disposition, 2022, 43 (6), pp.265-271. ⟨10.1002/bdd.2333⟩
Biopharmaceutics and Drug Disposition, 2022, 43 (6), pp.265-271. ⟨10.1002/bdd.2333⟩
International audience; HepaRG cells are highly-differentiated human hepatoma cells, which are increasingly recognized as a convenient cellular model for in vitro evaluation of hepatic metabolism, transport and/or toxicity of drugs. The present study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafb774200bfcbbb99b26adade8ac3af
https://pubmed.ncbi.nlm.nih.gov/36195987
https://pubmed.ncbi.nlm.nih.gov/36195987