Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Marc L. Goalstone"'
Autor:
Rajakrishnan Veluthakal, Daleep K. Arora, Marc L. Goalstone, Renu A. Kowluru, Anjaneyulu Kowluru
Publikováno v:
Cellular Physiology and Biochemistry, Vol 39, Iss 6, Pp 2110-2120 (2016)
Background/Aims: At least 300 prenylated proteins are identified in the human genome; the majority of which partake in a variety of cellular processes including growth, differentiation, cytoskeletal organization/dynamics and vesicle trafficking. Aber
Externí odkaz:
https://doaj.org/article/ac740baabdf948959d9532bc9e2cd9a4
Autor:
Charles Banfield, Marc L. Goalstone, Sami Hourieh, Jamie Bui, Greg B. Pott, Mark Tsurudome, Harsh Pratap
Publikováno v:
Medical Research Archives. 5
Atherosclerosis is a cardiovascular disease that begins with inflammation and ends in decreased lumen diameter, occlusion and rupture if not addressed appropriately. Markers of vascular inflammation are, but not limited to, increased expression of Ce
Autor:
Daniel Z. Mackesy, Marc L. Goalstone
Publikováno v:
Journal of Diabetes. 6:595-602
Background Atherosclerosis may be stimulated by the increased presence of insulin and tumor necrosis-factor-α (TNFα) with subsequent expression of vascular cell adhesion molecule-1 (VCAM-1). We hypothesized that extracellular signal-regulated kinas
Autor:
Subbiah Pugazhenthi, Marc L. Goalstone
Publikováno v:
Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 7 (2016)
Frontiers in Endocrinology, Vol 7 (2016)
The Editorial on the Research Topic Molecular Mechanism of Neuronal Dysfunction in the Diabetic Brain Insulin signaling plays a significant role in the brain synaptic function. Insulin resistance is associated with reductions in cerebral glucose meta
Publikováno v:
Journal of Inflammation (London, England)
Background Diabetes is quickly becoming the most widespread disorder in the Western world. Among the most prevalent effects of diabetes is atherosclerosis, which in turn is driven in part by inflammation. Both insulin and Tumor Necrosis Factor-alpha
Publikováno v:
ADMET and DMPK
Volume 4
Issue 3
ADMET and DMPK, Vol 4, Iss 3, Pp 232-240 (2016)
Volume 4
Issue 3
ADMET and DMPK, Vol 4, Iss 3, Pp 232-240 (2016)
VCAM-1 cell surface expression was determined by flow cytometry in rat aorta endothelial cells stimulated with insulin and/or Tumor Necrosis Factor-a in the absence or presence of short-hairpin RNA inhibitors of c-Jun N-terminal Kinase (JNK) and p38
Publikováno v:
Biochemical and Biophysical Research Communications. 391:895-898
A growing body of evidence implicates small G-proteins [e.g., Cdc42 and Rac1] in glucose-stimulated insulin secretion [GSIS] in the islet beta-cell. These signaling proteins undergo post-translational modifications [e.g., prenylation] at their C-term
Autor:
W. Troy Donahoo, Inga Gurevich, Rocio I. Pereira, Marc-Andre Cornier, Peter J. Eckel, James O. Hill, Rickard Westergren, Sven Enerbäck, Boris Draznin, Marc L. Goalstone, Robert H. Eckel
Publikováno v:
Obesity Research. 13:703-709
Objective: To determine whether macronutrient composition of a hypocaloric diet can enhance its effectiveness and whether insulin sensitivity (Si) affects the response to hypocaloric diets. Research Methods and Procedures: Obese nondiabetic insulin-s
Publikováno v:
Diabetes. 53:2735-2740
Insulin resistance is concomitant with type 2 diabetes, obesity, hypertension, and other features of the metabolic syndrome. Because insulin resistance is associated with cardiovascular disease, both scientists and physicians have taken great interes
Publikováno v:
Metabolism. 52:254-259
Platelet-derived growth factor (PDGF) is a potent inducer of vascular smooth muscle cell (VSMC) migration, whereas insulin, in physiological concentrations, helps maintain the nonproliferative phenotype of these cells. However, hyperinsulinemia (10 n