Výsledky vyhledávání - "Marc L. Filion"

A phase II trial of dovitinib in previously-treated advanced pleural mesothelioma: The Ontario Clinical Oncology Group

Autor: Marc L. Filion, Anita Bane, John R. Goffin, Desiree Hao, Mark Levine, Scott A. Laurie, Jean M. Seely, Christina L. Addison, Gregory R. Pond, Abderrahim Khomani, Natasha B. Leighl, Ashish Gupta

Publikováno v: Lung Cancer. 104:65-69

Objectives Following failure of a platinum-antifolate combination regimen, there is no standard therapy for advanced malignant pleural mesothelioma (MPM). The fibroblast growth factor receptor (FGFR) signaling pathways may be a relevant target in MPM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b225b19764cf0f5aa37f61ca03ad7226
https://doi.org/10.1016/j.lungcan.2016.12.004

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Effect of Positron Emission Tomography Imaging in Women With Locally Advanced Cervical Cancer

Autor: Gregory R. Pond, Margaret Anthes, Timothy J. Whelan, Mark Levine, Gillian Thomas, Marc L. Filion, Ur Metser, Kavita Dhamanaskar, Rajiv Samant, Chu-Shu Gu, Julie Arsenault, David D'Souza, Lorraine Elit, Ian S. Dayes, Karen Y. Gulenchyn, Anthony Fyles

Publikováno v: JAMA Network Open

Key Points Question In women with locally advanced carcinoma of the cervix who are candidates for chemotherapy and radiotherapy, does adding fludeoxyglucose F 18 positron emission tomography–computed tomography (PET-CT) to staging with CT of the ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15080951906f995d86bbb1a45cd9e18
https://doi.org/10.1001/jamanetworkopen.2018.2081

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The Transferable Tail: Fusion of the N-Terminal Acidic Extension of Heparin Cofactor II to α1-Proteinase Inhibitor M358R Specifically Increases the Rate of Thrombin Inhibition

Autor: Marc L. Filion, Varsha Bhakta, William P. Sheffield, Jason S. Sutherland

Publikováno v: Biochemistry. 45:11444-11452

The conversion of the reactive center bond of the serpin alpha1-proteinase inhibitor (alpha1-PI, also known as alpha1-antitrypsin) from Met-Ser to Arg-Ser decreases the rate at which it inhibits neutrophil elastase and endows it with the ability to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f9eafda929b0a8b6f87731ea33d994
https://doi.org/10.1021/bi0609624

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Full or partial substitution of the reactive center loop of alpha-1-proteinase inhibitor by that of heparin cofactor II: P1 Arg is required for maximal thrombin inhibition

Autor: Marc L. Filion, Varsha Bhakta, Peter S Liaw, Laurie H Nguyen, William P. Sheffield

Publikováno v: Biochemistry. 43(46)

The abundant plasma protein alpha(1)-proteinase inhibitor (alpha(1)-PI) physiologically inhibits neutrophil elastase (NE) and factor XIa and belongs to the serine protease inhibitor (serpin) protein superfamily. Inhibitory serpins possess a surface p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f0ddfad781f8f78e3ccc33b94e15b1
https://pubmed.ncbi.nlm.nih.gov/15544357

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