Anteroposterior axis patterning by early canonical Wnt signaling during hemichordate development.

Autor: Sébastien Darras, Jens H Fritzenwanker, Kevin R Uhlinger, Ellyn Farrelly, Ariel M Pani, Imogen A Hurley, Rachael P Norris, Michelle Osovitz, Mark Terasaki, Mike Wu, Jochanan Aronowicz, Marc Kirschner, John C Gerhart, Christopher J Lowe

Publikováno v: PLoS Biology, Vol 16, Iss 1, p e2003698 (2018)

The Wnt family of secreted proteins has been proposed to play a conserved role in early specification of the bilaterian anteroposterior (A/P) axis. This hypothesis is based predominantly on data from vertebrate embryogenesis as well as planarian rege

Externí odkaz: https://doaj.org/article/6b38e1692c7a43b48300973096d5c3f0

Dorsoventral patterning in hemichordates: insights into early chordate evolution.

Autor: Christopher J Lowe, Mark Terasaki, Michael Wu, Robert M Freeman, Linda Runft, Kristen Kwan, Saori Haigo, Jochanan Aronowicz, Eric Lander, Chris Gruber, Mark Smith, Marc Kirschner, John Gerhart

Publikováno v: PLoS Biology, Vol 4, Iss 9, p e291 (2006)

We have compared the dorsoventral development of hemichordates and chordates to deduce the organization of their common ancestor, and hence to identify the evolutionary modifications of the chordate body axis after the lineages split. In the hemichor

Externí odkaz: https://doaj.org/article/26a900b32d6147929294a42b0b1a368b

Towards standardization guidelines for in silico approaches in personalized medicine

Autor: Ingrid Kockum, Martin Golebiewski, Heike Moser, Marc Kirschner, Katharina Ó Cathaoir, Catherine Bjerre Collin, Dagmar Waltemath, Søren Brunak

Publikováno v: Journal of Integrative Bioinformatics
Brunak, S, Bjerre, C C, Ó Cathaoir, K, Golebiewski, M, Kirschner, M, Kockum, I, Moser, H & Waltemath, D 2020, ' Towards standardization guidelines for in silico approaches in personalized medicine ', Journal of integrative bioinformatics, vol. 17, no. 2-3 . https://doi.org/10.1515/jib-2020-0006
Journal of Integrative Bioinformatics, Vol 17, Iss 2-3, Pp 21-106 (2020)

Despite the ever-progressing technological advances in producing data in health and clinical research, the generation of new knowledge for medical benefits through advanced analytics still lags behind its full potential. Reasons for this obstacle are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127591ea0bb5e0f653c56f73c72725c9
https://doi.org/10.1515/jib-2020-0006

Systems Medicine: Sketching the Landscape

Autor: Marc, Kirschner

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1386

To understand the meaning of the term Systems Medicine and to distinguish it from seemingly related other expressions currently in use, such as precision, personalized, -omics, or big data medicine, its underlying history and development into present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b432b6485c53d1bb39b7df686e22129
https://pubmed.ncbi.nlm.nih.gov/26677176

On a possible evolutionary link of the stomochord of hemichordates to pharyngeal organs of chordates

Autor: Noriyuki, Satoh, Kunifumi, Tagawa, Christopher J, Lowe, Jr-Kai, Yu, Takeshi, Kawashima, Hiroki, Takahashi, Michio, Ogasawara, Marc, Kirschner, Kanako, Hisata, Yi-Hsien, Su, John, Gerhart

Publikováno v: Genesis (New York, N.Y. : 2000). 52(12)

As a group closely related to chordates, hemichordate acorn worms are in a key phylogenic position for addressing hypotheses of chordate origins. The stomochord of acorn worms is an anterior outgrowth of the pharynx endoderm into the proboscis. In 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2a19cb28e44b39e6f627e9882352402
https://pubmed.ncbi.nlm.nih.gov/25303744