Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Marc K. Halushka"'
Autor:
Jacob C. Scherba, Marc K. Halushka, Nicholas D. Andersen, Joseph J. Maleszewski, Andrew P. Landstrom, Nenad Bursac, Carolyn Glass
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract Hypertrophic cardiomyopathy (HCM) is a genetic disease of the sarcomere that causes otherwise unexplained cardiac hypertrophy and is associated with sudden death. While previous studies showed the role of the epigenetic modifier Brg1 in mous
Externí odkaz:
https://doaj.org/article/9ef311b9636c43918e8da9d9268310db
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The extracellular matrix (ECM) has historically been explored through proteomic methods. Whether or not global transcriptomics can yield meaningful information on the human matrisome is unknown. Gene expression data from 17,382 samples acros
Externí odkaz:
https://doaj.org/article/9d288ca36166428b8cedf93868f543b4
Autor:
Rohan X. Verma, Suraj Kannan, Brian L. Lin, Katherine M. Fomchenko, Tim O. Nieuwenhuis, Arun H. Patil, Clarisse Lukban, Xiaoping Yang, Karen Fox-Talbot, Matthew N. McCall, Chulan Kwon, David A. Kass, Avi Z. Rosenberg, Marc K. Halushka
Publikováno v:
Skeletal Muscle, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Background Skeletal muscle myofibers can be separated into functionally distinct cell types that differ in gene and protein expression. Current single cell expression data is generally based upon single nucleus RNA, rather than whole myofibe
Externí odkaz:
https://doaj.org/article/4c8d78ac599048469743702ada0190f6
Autor:
Tarek Zghaib, Anneline S. J. M. Te Riele, Cynthia A. James, Neda Rastegar, Brittney Murray, Crystal Tichnell, Marc K. Halushka, David A. Bluemke, Harikrishna Tandri, Hugh Calkins, Ihab R. Kamel, Stefan Loy Zimmerman
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 23, Iss 1, Pp 1-11 (2021)
Abstract Background Left ventricular (LV) fibrofatty infiltration in arrhythmogenic right ventricular (RV) dysplasia/cardiomyopathy (ARVD/C) has been reported, however, detailed cardiovascular magnetic resonance (CMR) characteristics and association
Externí odkaz:
https://doaj.org/article/fd71263dd67d4e3f95b824579faec383
Autor:
Ana E. Jenike, Marc K. Halushka
Publikováno v:
Biomarker Research, Vol 9, Iss 1, Pp 1-7 (2021)
Abstract miRNA-21 is among the most abundant and highly conserved microRNAs (miRNAs) recognized. It is expressed in essentially all cells where it performs vital regulatory roles in health and disease. It is also frequently claimed to be a biomarker
Externí odkaz:
https://doaj.org/article/3691d6dae46748618e37815776426c6c
Autor:
Tricia R. Cottrell, Frederic Askin, Marc K. Halushka, Livia Casciola‐Rosen, Zsuzsanna H. McMahan
Publikováno v:
ACR Open Rheumatology, Vol 2, Iss 11, Pp 657-661 (2020)
Background Among the autoimmune rheumatic diseases, it is striking that autoantibodies targeting ubiquitously expressed proteins (eg, topoisomerase‐1) associate with specific clinical complications (eg, interstitial lung disease [ILD]). It has been
Externí odkaz:
https://doaj.org/article/f6a24468d6824a4e8076b10617ecf282
Autor:
Taejoon Won, Megan K. Wood, David M. Hughes, Monica V. Talor, Zexu Ma, Jowaly Schneider, John T. Skinner, Beejan Asady, Erin Goerlich, Marc K. Halushka, Allison G. Hays, Deok-Ho Kim, Chirag R. Parikh, Avi Z. Rosenberg, Isabelle Coppens, Roger A. Johns, Nisha A. Gilotra, Jody E. Hooper, Andrew Pekosz, Daniela Čiháková
Publikováno v:
EBioMedicine, Vol 75, Iss , Pp 103812- (2022)
Summary: Background: Thromboembolism is a life-threatening manifestation of coronavirus disease 2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells in the lungs during COVID-19. Methods: We obtained the lung speci
Externí odkaz:
https://doaj.org/article/fa15652ffd1a47a2a1954f6284a33f0d
Autor:
Tim O. Nieuwenhuis, Stephanie Y. Yang, Rohan X. Verma, Vamsee Pillalamarri, Dan E. Arking, Avi Z. Rosenberg, Matthew N. McCall, Marc K. Halushka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Sample contamination has been reported in high throughput RNA sequencing. Here the authors analyze the RNA sequencing data from the Genotype-Tissue Expression project and describe how highly expressed, tissue specific genes contaminate across samples
Externí odkaz:
https://doaj.org/article/fede4787d2dc40708b7ce5f17be141ab
Autor:
Sabra C. Lewsey, MD, MPH, Kavita Sharma, MD, Ahmet Kilic, MD, Marc K. Halushka, MD, PhD, Joban Vaishnav, MD, Ilan S. Wittstein, MD, Harikrishna Tandri, MBBS, Hugh Calkins, MD, Cynthia A. James, SM, PhD, CGC, Nisha A. Gilotra, MD
Publikováno v:
JACC: Case Reports, Vol 2, Iss 1, Pp 59-63 (2020)
We report a case of a woman with arrhythmogenic right ventricular cardiomyopathy (ARVC) who presented with severe right-sided heart failure and cardiac cirrhosis that mandated heart-liver transplantation. This case highlights an emerging sex-based di
Externí odkaz:
https://doaj.org/article/e3e380360a6945d2a3d284a98f00325e
Autor:
Tony Y. Wang, Dan E. Arking, Joseph J. Maleszewski, Karen Fox-Talbot, Tim O. Nieuwenhuis, Lakshmi Santhanam, Renu Virmani, Avi Z. Rosenberg, Marc K. Halushka
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Abstract Sex disparities modulate cardiac function, although the proteins and mechanisms remain to be elucidated. We recently demonstrated a mosaic pattern of protein expression in the heart for over 100 proteins. Here we investigate one of these pro
Externí odkaz:
https://doaj.org/article/c652c0835d9b4550b6cb7d45311e73b4