Zobrazeno 1 - 10
of 350
pro vyhledávání: '"Marc K, Hellerstein"'
Autor:
Alec Bizieff, Maggie Cheng, Kelvin Chang, Hussein Mohammed, Naveed Ziari, Edna Nyangau, Mark Fitch, Marc K. Hellerstein
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-23 (2024)
Abstract Changes in protein turnover play an important role in dynamic physiological processes, including skeletal muscle regeneration, which occurs as an essential part of tissue repair after injury. The inability of muscle tissue to recapitulate th
Externí odkaz:
https://doaj.org/article/0ee76b2553884fee903e25d318b33077
Autor:
En Cheng, Bette J. Caan, Peggy M. Cawthon, William J. Evans, Marc K. Hellerstein, Mahalakshmi Shankaran, Kristin L. Campbell, Alexandra M. Binder, Barbara Sternfeld, Jeffrey A. Meyerhardt, Kathryn H. Schmitz, Elizabeth M. Cespedes Feliciano
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 6, Pp 2768-2778 (2023)
Abstract Background Low skeletal muscle mass (myopenia) is common in cancer populations and is associated with functional decline and mortality, but prior oncology studies did not assess total body skeletal muscle mass. Instead, they measured surroga
Externí odkaz:
https://doaj.org/article/2d60ccf5f7264903bfc6650d7af16625
Autor:
Daniel B. Reeves, Charline Bacchus-Souffan, Mark Fitch, Mohamed Abdel-Mohsen, Rebecca Hoh, Haelee Ahn, Mars Stone, Frederick Hecht, Jeffrey Martin, Steven G. Deeks, Marc K. Hellerstein, Joseph M. McCune, Joshua T. Schiffer, Peter W. Hunt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Persistence of HIV in people living with HIV (PWH) on suppressive antiretroviral therapy (ART) has been linked to physiological mechanisms of CD4+ T cells. Here, in the same 37 male PWH on ART we measure longitudinal kinetics of HIV DNA and
Externí odkaz:
https://doaj.org/article/ffc6674a545d4c69bd5e2cf799eb8bae
Autor:
M. Alan Dawson, Stephen R. Hennigar, Mahalakshmi Shankaran, Alyssa M. Kelley, Bradley J. Anderson, Edna Nyangau, Tyler J. Field, William J. Evans, Marc K. Hellerstein, James P. McClung, Stefan M. Pasiakos, Claire E. Berryman
Publikováno v:
Physiological Reports, Vol 11, Iss 23, Pp n/a-n/a (2023)
Abstract Previous studies have demonstrated both energy restriction (ER) and higher protein (HP), lower carbohydrate (LC) diets downregulate hepatic de novo lipogenesis. Little is known about the independent and combined impact of ER and HP/LC diets
Externí odkaz:
https://doaj.org/article/f37669e2472442d0b80cd04357254140
Autor:
Eric J. Lawitz, Kelvin W. Li, Edna Nyangau, Tyler John Field, Jen-Chieh Chuang, Andrew Billin, Lulu Wang, Ya Wang, Ryan S. Huss, Chuhan Chung, G. Mani Subramanian, Robert P. Myers, Marc K. Hellerstein
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 9, Pp 100250- (2022)
Abstract: De novo lipogenesis (DNL) converts carbon substrates to lipids. Increased hepatic DNL could contribute to pathogenic liver triglyceride accumulation in nonalcoholic steatohepatitis (NASH) and therefore may be a potential target for pharmaco
Externí odkaz:
https://doaj.org/article/4ec0975a815c4b149a578efd36195ac9
Autor:
Vincent Morcilla, Charline Bacchus-Souffan, Katie Fisher, Bethany A. Horsburgh, Bonnie Hiener, Xiao Qian Wang, Timothy E. Schlub, Mark Fitch, Rebecca Hoh, Frederick M. Hecht, Jeffrey N. Martin, Steven G. Deeks, Marc K. Hellerstein, Joseph M. McCune, Peter W. Hunt, Sarah Palmer
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
The design of future HIV-1 curative therapies requires a more thorough understanding of the distribution of genetically intact HIV-1 within T-cell subsets as well as the cellular mechanisms that maintain this reservoir. These genetically intact and p
Externí odkaz:
https://doaj.org/article/9840134545d946e5afd4453b7f75a3e7
Autor:
Veronika I Zarnitsyna, Rama S Akondy, Hasan Ahmed, Donald J McGuire, Vladimir G Zarnitsyn, Mia Moore, Philip L F Johnson, Rafi Ahmed, Kelvin W Li, Marc K Hellerstein, Rustom Antia
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009468 (2021)
Understanding how immunological memory lasts a lifetime requires quantifying changes in the number of memory cells as well as how their division and death rates change over time. We address these questions by using a statistically powerful mixed-effe
Externí odkaz:
https://doaj.org/article/d833a13fe7e34b38b5d1e8330ab10a2f
Autor:
Timothy D Allerton, Jonathan J Savoie, Mark D Fitch, Marc K Hellerstein, Jacqueline M Stephens, Ursula White
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0244804 (2021)
Exercise has beneficial effects on metabolism and health. Although the skeletal muscle has been a primary focus, exercise also mediates robust adaptations in white adipose tissue. To determine if exercise affects in vivo adipocyte formation, fifty-tw
Externí odkaz:
https://doaj.org/article/5f86e9f0877c404ebcebfb02c58d442e
Autor:
Charline Bacchus-Souffan, Mark Fitch, Jori Symons, Mohamed Abdel-Mohsen, Daniel B Reeves, Rebecca Hoh, Mars Stone, Joseph Hiatt, Peggy Kim, Abha Chopra, Haelee Ahn, Vanessa A York, Daniel L Cameron, Frederick M Hecht, Jeffrey N Martin, Steven A Yukl, Simon Mallal, Paul U Cameron, Steven G Deeks, Joshua T Schiffer, Sharon R Lewin, Marc K Hellerstein, Joseph M McCune, Peter W Hunt
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009214 (2021)
The precise role of CD4 T cell turnover in maintaining HIV persistence during antiretroviral therapy (ART) has not yet been well characterized. In resting CD4 T cell subpopulations from 24 HIV-infected ART-suppressed and 6 HIV-uninfected individuals,
Externí odkaz:
https://doaj.org/article/1c92de8d5c364b769ed3f828c4efac4a
Autor:
Raya Ahmed, Kelly L. Miners, Julio Lahoz-Beneytez, Rhiannon E. Jones, Laureline Roger, Christina Baboonian, Yan Zhang, Eddie C.Y. Wang, Marc K. Hellerstein, Joseph M. McCune, Duncan M. Baird, David A. Price, Derek C. Macallan, Becca Asquith, Kristin Ladell
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108501- (2020)
Summary: A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells nonetheless accumulate with age and expand numerically in response to persistent ant
Externí odkaz:
https://doaj.org/article/7885536d2b5e42149b0d76509a9181e5