Amphipathic DNA Polymers Inhibit Hepatitis C Virus Infection by Blocking Viral Entry

Autor: Marlène Dreux, Takanobu Kato, Takuya Matsumura, Jean Marc Juteau, François-Loïc Cosset, Michio Imamura, Yong Yuan Zhang, Andrew Vaillant, Nobuhiko Hiraga, Kazuaki Chayama, Zongyi Hu, T. Jake Liang

Publikováno v: Gastroenterology
Gastroenterology, 2009, 137 (2), pp.673-681. ⟨10.1053/j.gastro.2009.04.048⟩
Gastroenterology, WB Saunders, 2009, 137 (2), pp.673-681. ⟨10.1053/j.gastro.2009.04.048⟩

International audience; BACKGROUND & AIMS: Hepatitis C virus (HCV) gains entry into susceptible cells by interacting with cell surface receptor(s). Viral entry is an attractive target for antiviral development because of the highly conserved mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498528eb4b5ed0ce7a03e7d2611bc435
https://doi.org/10.1053/j.gastro.2009.04.048

Amphipathic DNA Polymers are Candidate Vaginal Microbicides and Block Herpes Simplex Virus Binding, Entry and Viral Gene Expression

Autor: Betsy C. Herold, Natalia Cheshenko, Esmeralda Guzman, Nathalie Goyette, Andrew Vaillant, Vikas Shende, Marla J. Keller, Jean Marc Juteau, Guy Boivin

Publikováno v: Antiviral Therapy. 12:1147-1156

Background Amphipathic DNA polymers are promising therapies for the prevention of HIV and genital herpes infections. Recent studies on a panel of such compounds indicated potent activity against HIV binding and entry. This current study was conducted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ddcaaa45285611adccac7408976703e
https://doi.org/10.1177/135965350701200810

Potent Antiscrapie Activities of Degenerate Phosphorothioate Oligonucleotides

Autor: Emily A. Olsen, David A. Kocisko, Kil Sun Lee, Kevin M. Arnold, Nadine Bertholet, Jean-Marc Juteau, Byron Caughey, Andrew Vaillant, Richard E. Race

Publikováno v: Antimicrobial Agents and Chemotherapy. 50:1034-1044

Although transmissible spongiform encephalopathies (TSEs) are incurable, a key therapeutic approach is prevention of conversion of the normal, protease-sensitive form of prion protein (PrP-sen) to the disease-specific protease-resistant form of prion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98b7fe3d7cf82a1d1571386b6fefe8c
https://doi.org/10.1128/aac.50.3.1034-1044.2006

Sequence of the bphD gene encoding 2-hydroxy-6-oxo-(phenyl/ chlorophenyl)hexa-2,4-dienoic acid (HOP/cPDA) hydrolase involved in the biphenyl/polychlorinated biphenyl degradation pathway in Comamonas testosteroni: Evidence suggesting involvement of Ser112 in catalytic activity

Autor: Darakhshan Ahmad, Angéle Larose, Janique Bergeron, Judith Fraser, Mohammad Sondossi, Atif Khan, Michel Sylvestre, Jean Marc Juteau

Publikováno v: Scopus-Elsevier

The nucleotide sequence of bphD, encoding 2-hydroxy-6-oxo-(phenyl/chlorophenyl)hexa-2,4-dienoic acid hydrolase involved in the biphenyl/polychlorinated biphenyl degradation pathway of Comamonas testosteroni strain B-356, was determined. Comparison of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a062f8f0252630335739f58dc0c25b
https://doi.org/10.1016/0378-1119(95)00073-f

Amphipathic DNA polymers exhibit antiviral activity against systemic Murine Cytomegalovirus infection

Autor: Fernando J. Bravo, Andrew Vaillant, David I. Bernstein, Louis Flamand, Jean-Marc Juteau, Andrea P Sewell, Rhonda D. Cardin, James E. Cummins

Publikováno v: Virology Journal, Vol 6, Iss 1, p 214 (2009)
Virology Journal

Background Phosphorothioated oligonucleotides (PS-ONs) have a sequence-independent, broad spectrum antiviral activity as amphipathic polymers (APs) and exhibit potent in vitro antiviral activity against a broad spectrum of herpesviruses: HSV-1, HSV-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d148812f60fea12da1cc80e16703f6d0
http://www.virologyj.com/content/6/1/214