A Symphytum officinale Root Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF-κB Signaling

Autor: Jacqueline Seigner, Marc Junker-Samek, Alberto Plaza, Gilda D‘Urso, Milena Masullo, Sonia Piacente, Yvonne M. Holper-Schichl, Rainer de Martin

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Symphytum officinale, commonly known as comfrey, constitutes a traditional medicinal plant with a long-standing therapeutic history, and preparations thereof have been widely used for the treatment of painful muscle and joint complaints, wound and bo

Externí odkaz: https://doaj.org/article/25cbae7a37574f719c337008680a5875

Multiplexed coding by cerebellar Purkinje neurons

Autor: Sungho Hong, Mario Negrello, Marc Junker, Aleksandra Smilgin, Peter Thier, Erik De Schutter

Publikováno v: eLife, Vol 5 (2016)

Purkinje cells (PC), the sole output neurons of the cerebellar cortex, encode sensorimotor information, but how they do it remains a matter of debate. Here we show that PCs use a multiplexed spike code. Synchrony/spike time and firing rate encode dif

Externí odkaz: https://doaj.org/article/038993b8be2d4044988a6f8091b3d123

The same oculomotor vermal Purkinje cells encode the different kinematics of saccades and of smooth pursuit eye movements

Autor: Zong-Peng Sun, Peter Thier, Peter W. Dicke, Marc Junker, Aleksandra Smilgin

Publikováno v: Scientific Reports

Saccades and smooth pursuit eye movements (SPEM) are two types of goal-directed eye movements whose kinematics differ profoundly, a fact that may have contributed to the notion that the underlying cerebellar substrates are separated. However, it is s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387ade5f8d8dd5a4e8254de194c8248c
https://pubmed.ncbi.nlm.nih.gov/28091557

Individual neurons in the caudal fastigial oculomotor region convey information on both macro- and microsaccades

Autor: Peter W. Dicke, Peter Thier, Zong-Peng Sun, Marc Junker

Publikováno v: The European journal of neuroscience. 44(8)

Recent studies have suggested that microsaccades, the small amplitude saccades made during fixation, are precisely controlled. Two lines of evidence suggest that the cerebellum plays a key role not only in improving the accuracy of macrosaccades but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36d1d10c8cb0dddb27048848fa48ee2
https://pubmed.ncbi.nlm.nih.gov/27453159

Duration of Purkinje cell complex spikes increases with their firing frequency

Autor: Michele Giugliano, Alla Ignashchenkova, Mario Negrello, Erik De Schutter, Aleksandra Smilgin, Marc Junker, João Couto, Peter Thier, Pascal Warnaar

Publikováno v: Frontiers in cellular neuroscience
Frontiers in Cellular Neuroscience, Vol 9 (2015)
Frontiers in Cellular Neuroscience, 9:122. Frontiers Media S.A.
Frontiers in Cellular Neuroscience

Climbing fiber (CF) triggered complex spikes (CS) are massive depolarization bursts in the cerebellar Purkinje cell, showing several high frequency spikelet components (+/- 600 Hz). Since its early observations, the CS is known to vary in shape. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92115122d905a1684295ec5b839d808
https://hdl.handle.net/10067/1255470151162165141