Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Marc Joiret"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2453-2464 (2024)
The kinetics of the protein elongation cycle by the ribosome depends on intertwined factors. One of these factors is the electrostatic interaction of the nascent protein with the ribosome exit tunnel. In this computational biology theoretical study,
Externí odkaz:
https://doaj.org/article/724f2b0efb594b5aa4ac512751a11362
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3768-3795 (2023)
The central function of the large subunit of the ribosome is to catalyze peptide bond formation. This biochemical reaction is conducted at the peptidyl transferase center (PTC). Experimental evidence shows that the catalytic activity is affected by t
Externí odkaz:
https://doaj.org/article/edc77a47b63d45179c2a014bca29d8b4
Autor:
Marc Joiret, Marine Leclercq, Gaspard Lambrechts, Francesca Rapino, Pierre Close, Gilles Louppe, Liesbet Geris
Publikováno v:
Frontiers in Artificial Intelligence, Vol 6 (2023)
The genetic code is textbook scientific knowledge that was soundly established without resorting to Artificial Intelligence (AI). The goal of our study was to check whether a neural network could re-discover, on its own, the mapping links between cod
Externí odkaz:
https://doaj.org/article/5953f6390c294c27883db9ffb648b52e
Autor:
Francesca Rapino, Zhaoli Zhou, Ana Maria Roncero Sanchez, Marc Joiret, Christian Seca, Najla El Hachem, Gianluca Valenti, Sara Latini, Kateryna Shostak, Liesbet Geris, Ping Li, Gang Huang, Gabriel Mazzucchelli, Dominique Baiwir, Christophe J. Desmet, Alain Chariot, Michel Georges, Pierre Close
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Wobble uridine (U34) tRNA modifications are important for the decoding of AA-ending codons. Here the authors show that while the U34-codon content of mRNAs are predictive of changes in ribosome translation elongation, the resulting outcome in protein
Externí odkaz:
https://doaj.org/article/c065fd32e605402394e0d38dfe8266a8
Publikováno v:
BioData Mining, Vol 12, Iss 1, Pp 1-23 (2019)
Abstract Background In Genome-Wide Association Studies (GWAS), the concept of linkage disequilibrium is important as it allows identifying genetic markers that tag the actual causal variants. In Genome-Wide Association Interaction Studies (GWAIS), si
Externí odkaz:
https://doaj.org/article/7079e389d2fa4814aadad68b0100c97b
Publikováno v:
BioData Mining, Vol 15, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/6e77a314e51147ee9817bf885d4aa4ca
Autor:
Jérémie Zappia, Marc Joiret, Christelle Sanchez, Cécile Lambert, Liesbet Geris, Marc Muller, Yves Henrotin
Publikováno v:
Biomolecules, Vol 10, Iss 1, p 80 (2020)
The extracellular matrix can trigger cellular responses through its composition and structure. Major extracellular matrix components are the proteoglycans, which are composed of a core protein associated with glycosaminoglycans, among which the small
Externí odkaz:
https://doaj.org/article/81e2a973072041759626278792ecf30e
The central function of the large subunit of the ribosome is to catalyze peptide bond formation. This biochemical reaction is conducted at the peptidyl transferase center (PTC). Experimental evidence shows that the catalytic activity is affected by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e14f1c38d61590d25c1b08368943bb6
https://doi.org/10.1101/2022.03.07.483325
https://doi.org/10.1101/2022.03.07.483325
Publikováno v:
Physical Review E. 105
The impact of ribosome exit tunnel electrostatics on the protein elongation rate or on forces acting upon the nascent polypeptide chain are currently not fully elucidated. In the past, researchers have measured the electrostatic potential inside the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a0e00b7937f8956c7537ab43d3b1bd
https://doi.org/10.1103/physreve.105.014409
https://doi.org/10.1103/physreve.105.014409
The impact of the ribosome exit tunnel electrostatics on the protein elongation rate or on the forces acting upon the nascent polypeptide chain are currently not fully elucidated. In the past, researchers have measured the electrostatic potential ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4598ee362655a602031b17538d4e046b
https://doi.org/10.1101/2020.10.20.346684
https://doi.org/10.1101/2020.10.20.346684