Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Marc J. Evanchik"'
Autor:
Joshua A Stern, Svetlana Markova, Yu Ueda, Jae B Kim, Peter J Pascoe, Marc J Evanchik, Eric M Green, Samantha P Harris
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168407 (2016)
Hypertrophic cardiomyopathy (HCM) is an inherited disease of the heart muscle characterized by otherwise unexplained thickening of the left ventricle. Left ventricular outflow tract (LVOT) obstruction is present in approximately two-thirds of patient
Externí odkaz:
https://doaj.org/article/707fad5635a34c6db49cf36be19e0715
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
Autor:
Joshua M. Gorham, Yonghong Song, Johan D. Oslob, Christine E. Seidman, Brooke C. Harrison, Jonathan G. Seidman, Marc J. Evanchik, Robert S. McDowell, Robert L. Anderson, Leslie A. Leinwand, James A. Spudich, Hiroko Wakimoto, William Wan, Hector M. Rodriguez, Eric M. Green, Marcus Henze, Raja Kawas
Publikováno v:
Science. 351:617-621
Powering down yields a healthier heart In hypertrophic cardiomyopathy (HCM), the heart muscle enlarges and becomes progressively less efficient at pumping blood. HCM can be caused by mutations in components of the sarcomere (the heart's contractile u
Autor:
Marc J. Evanchik, Priscilla Brun, John C L Erve, Nicole V Haste, Mark P. Grillo, Svetlana Markova, Ryan Dick, Timothy J. Carlson, James P Driscoll
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 49(6)
Mavacamten is a small molecule modulator of cardiac myosin designed as an orally administered drug for the treatment of patients with hypertrophic cardiomyopathy. The current study objectives were to assess the preclinical pharmacokinetics of mavacam
Autor:
Heather Bogie, Marcus Henze, John Yucel, Sarah Fernandes, Brain Ferguson, Marc J. Evanchik, Carlos L Rio, Christopher Zambataro
Publikováno v:
The FASEB Journal. 32
Autor:
Eric M Green, Robert M Weiss, Abhay Divekar, Sadie R Bartholomew Ingle, Marcus Henze, Raja Kawas, Lindsey Gifford, Melissa K Davis, Frank Rohret, Daniel R Thedens, Hector M Rodriguez, Marc J Evanchik, Robert L Anderson, Jessica Sieren, Christopher S Rogers, David K Meyerholz, Ferhaan Ahmad
Publikováno v:
Circulation Research. 121
Introduction: Hypertrophic cardiomyopathy (HCM) is a heritable disease of heart muscle associated with increased risk of heart failure and sudden death. Mutations in genes encoding sarcomere proteins are commonly associated with HCM. However, the mec
Autor:
Marcus Henze, A.J. Yucel, Christopher Zambataro, Marc J. Evanchik, Heather Bogie, Sarah Fernandes, Carlos del Rio, Brain Ferguson
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Autor:
Beth Geist, Amanda LaRose, Yukie Ueyama, Carlos del Rio, Marc J. Evanchik, Robert L. Hamlin, Bradley L. Youngblood
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 99:106595
Autor:
Anu R. Anto, Ferhaan Ahmad, Kristina Green, Robert E. Anderson, Fiona K. Wong, Marcus Henze, Marc J. Evanchik, Carlos del Rio
Publikováno v:
Journal of Molecular and Cellular Cardiology. 124:107
Publikováno v:
Journal of Molecular and Cellular Cardiology. 124:106
Autor:
Shirley Q. Feng, Lily W. Hu, Hanbiao Yang, Mohanram Sivaraja, Russell Johnson, Robert S. McDowell, Haiying Cai, Julie Lai, Yuko Kosaka, Marc J. Evanchik, Cristiana A. Zaharia, Johan D. Oslob, Samnang Tep
Publikováno v:
ACS Medicinal Chemistry Letters. 4:113-117
Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described. The compounds are shown to have antiviral (HCV replicon) activities that track with their biochemical activities. The most potent analogue (compound 19) also inhibit