A novel mode of regulation of the Staphylococcus aureus Vancomycin-resistance-associated response regulator VraR mediated by Stk1 protein phosphorylation

Autor: Grégory Baronian, Marc J. Canova, Virginie Molle, Solène Brelle, Martin Cohen-Gonsaud, Markus Bischoff

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2014, 447 (1), pp.165-171. ⟨10.1016/j.bbrc.2014.03.128⟩
Biochemical and Biophysical Research Communications, 2014, 447 (1), pp.165-171. ⟨10.1016/j.bbrc.2014.03.128⟩

The Staphylococcus aureus Vancomycin-resistance-associated response regulator VraR is known as an important response regulator, member of the VraTSR three-component signal transduction system that modulates the expression of the cell wall stress stim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ec99fa82c0a36c626d29f4a29c116e
https://doi.org/10.1016/j.bbrc.2014.03.128

TheMycobacterium tuberculosisGroEL1 Chaperone Is a Substrate of Ser/Thr Protein Kinases

Autor: Marc J. Canova, Virginie Molle, Laurent Kremer

Publikováno v: Journal of Bacteriology
Journal of Bacteriology, American Society for Microbiology, 2009, 191 (8), pp.2876-2883. ⟨10.1128/JB.01569-08⟩
Journal of Bacteriology, American Society for Microbiology, 2009, 191 (8), pp.2876-83. ⟨10.1128/JB.01569-08⟩

We demonstrate thatMycobacterium tuberculosisGroEL1 is phosphorylated by PknF at two positions, Thr25 and Thr54. Unexpectedly,Mycobacterium smegmatisGroEL1 is not a substrate of its cognate PknF. This study shows that the phosphorylation profiles of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3bd00bb0037e059e058753cbc1d3cd
https://doi.org/10.1128/jb.01569-08

Bacterial inactivation of the anticancer drug doxorubicin

Autor: Gerard D. Wright, Kalinka Koteva, Marc J. Canova, Nicholas Waglechner, Inga Kireeva, Inas J. Radhi, Erin L. Westman

Publikováno v: Chemistrybiology. 19(10)

SummaryMicrobes are exposed to compounds produced by members of their ecological niche, including molecules with antibiotic or antineoplastic activities. As a result, even bacteria that do not produce such compounds can harbor the genetic machinery t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f27a6a8ac414c27902f0b65d1a3d82b
https://pubmed.ncbi.nlm.nih.gov/23102216

The MurC ligase essential for peptidoglycan biosynthesis is regulated by the serine/threonine protein kinase PknA in $Corynebacterium\ glutamicum$

Autor: Delphine Patin, Michel Becchi, Isabelle Zanella-Cléon, Michal Letek, José A. Gil, Virginie Molle, Luis M. Mateos, Dominique Mengin-Lecreulx, Marc J. Canova, María Fiuza

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2008, 283 (52), pp.36553-36563. ⟨10.1074/jbc.M807175200⟩

The Mur ligases play an essential role in the biosynthesis of bacterial cell-wall peptidoglycan and thus represent attractive targets for the design of novel antibacterials. These enzymes catalyze the stepwise formation of the peptide moiety of the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86df469068b0e3dcef2e6f6623ae9a4b
https://hal.archives-ouvertes.fr/hal-02282881/document

pETPhos: a customized expression vector designed for further characterization of Ser/Thr/Tyr protein kinases and their substrates

Autor: Laurent Kremer, Virginie Molle, Marc J. Canova

Publikováno v: Plasmid
Plasmid, Elsevier, 2008, 60 (2), pp.149-53. ⟨10.1016/j.plasmid.2008.05.002⟩

International audience; Bacterial genomics revealed the widespread distribution of serine/threonine protein kinases (STPKs), which regulate various cellular processes. However, understanding the role of phosphorylation in prokaryotes has been hampere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef11e22c53b28967058d6bedaa1f94ae
https://pubmed.ncbi.nlm.nih.gov/18597845