Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Marc J. Brouillette"'
Autor:
Mitchell C. Coleman, Marc J. Brouillette, Nicholas S. Andresen, Rebecca E. Oberley-Deegan, James M. Martin
Publikováno v:
Antioxidants, Vol 6, Iss 4, p 98 (2017)
Post-traumatic osteoarthritis can develop as a result of the initial mechanical impact causing the injury and also as a result of chronic changes in mechanical loading of the joint. Aberrant mechanical loading initiates excessive production of reacti
Externí odkaz:
https://doaj.org/article/2e65e1db3d16494db0540cb42b239447
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 3 (2015)
Traumatic injuries of articular cartilage result in the formation of a cartilage lesion and contribute to cartilage degeneration and the risk of osteoarthritis (OA). A better understanding of the framework for the formation of a cartilage lesion form
Externí odkaz:
https://doaj.org/article/6473e5c7646144eaa7c5b56ab36ee41a
Publikováno v:
Biomedical Engineering and Computational Biology, Vol 14 (2023)
Background and objectives: Femurs affected by metastatic bone disease (MBD) frequently undergo surgery to prevent impending pathologic fractures due to clinician-perceived increases in fracture risk. Finite element (FE) models can provide more object
Externí odkaz:
https://doaj.org/article/9acdf0ac03fc44e6adab44cea23d383e
Autor:
Douglas C. Fredericks, Hyeong Hun Choe, Ino Song, James A. Martin, L.R. Jaidev, Dongrim Seol, Marc J. Brouillette, Aliasger K. Salem, Hongjun Zheng, Emily B Petersen
Publikováno v:
Hum Gene Ther
Objective Lubricin, a glycoprotein encoded by the proteoglycan 4 (PRG4) gene, is an essential boundary lubricant that reduces friction between articular cartilage surfaces. The loss of lubricin subsequent to joint injury plays a role in the pathogene
Publikováno v:
Journal of Orthopaedic Research. 40:2609-2619
Variations in chondrocyte density and organization in cartilage histology sections are associated with osteoarthritis progression. Rapid, accurate quantification of these two features can facilitate the evaluation of cartilage health and advance the
Publikováno v:
Journal of Orthopaedic Research. 40:1203-1212
The goal of this study was to develop, validate, and implement an image analysis framework to automatically analyze chondrocytes in 3D image stacks of cartilage acquired using a fluorescent confocal microscope. Source specimens consist of viable oste
Publikováno v:
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine. 236(9)
Metastatic bone disease (MBD) is often managed by non-specialized orthopedic surgeons who rely on Mirels’ criteria to predict pathologic fracture risk. However, low specificity of Mirels’ criteria implies many lesions are scored at high fracture
Autor:
Holly D. Aitken, Robert W. Westermann, Nicholas I. Bartschat, Alex M. Meyer, Marc J. Brouillette, Natalie A. Glass, John C. Clohisy, Michael C. Willey, Jessica E. Goetz
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research SocietyREFERENCES. 40(11)
Hip dysplasia is known to lead to premature osteoarthritis. Computational models of joint mechanics have documented elevated contact stresses in dysplastic hips, but elevated stress has not been directly associated with regional cartilage degeneratio
Publikováno v:
Free Radical Biology and Medicine. 180:s62
Autor:
Linjun, Yang, Mitchell C, Coleman, Madeline R, Hines, Paige N, Kluz, Marc J, Brouillette, Jessica E, Goetz
Publikováno v:
Iowa Orthop J
BACKGROUND: Histology-based methods are commonly used in osteoarthritis (OA) research because they provide detailed information about cartilage health at the cellular and tissue level. Computer-based cartilage scoring systems have previously been dev