Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Marc J C, Scanio"'
Autor:
Meena V, Patel, Hillary M, Peltier, Mark A, Matulenko, John R, Koenig, Marc J, C Scanio, Rebecca J, Gum, Odile F, El-Kouhen, Meagan M, Fricano, Greta L, Lundgaard, Torben, Neelands, Xu-Feng, Zhang, Cenchen, Zhan, Madhavi, Pai, Nayereh, Ghoreishi-Haack, Thomas, Hudzik, Gary, Gintant, Ruth, Martin, Steve, McGaraughty, Jun, Xu, Daniel, Bow, John C, Kalvass, Philip R, Kym, David A, DeGoey, Michael E, Kort
Publikováno v:
Bioorganicmedicinal chemistry. 63
The voltage-gated sodium channel Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd1fb7249454a3a0f2ca17d9cb54dd42
https://pubmed.ncbi.nlm.nih.gov/35436748
https://pubmed.ncbi.nlm.nih.gov/35436748
Autor:
Marc J C, Scanio, Xenia B, Searle, Bo, Liu, John R, Koenig, Robert J, Altenbach, Gregory A, Gfesser, Andrew, Bogdan, Stephen, Greszler, Gang, Zhao, Ashvani, Singh, Yihong, Fan, Andrew M, Swensen, Timothy, Vortherms, Arlene, Manelli, Corina, Balut, Wenqing, Gao, Hong, Yong, Michael, Schrimpf, Chris, Tse, Philip, Kym, Xueqing, Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 72:128843
Cystic fibrosis (CF) is an autosomal recessive disease resulting from mutations on both copies of the CFTR gene. Phenylalanine deletion at position 508 of the CFTR protein (F508del-CFTR) is the most frequent mutation in CF patients. Currently, the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a2a884faa7901f5e486831d30b03cd
https://doi.org/10.1016/j.bmcl.2022.128843
https://doi.org/10.1016/j.bmcl.2022.128843
Autor:
Wenqing Gao, Robert J. Altenbach, Gang Zhao, John R. Koenig, Greszler Stephen N, Searle Xenia B, Gregory A. Gfesser, Hong Yong, Corina Balut, Marc J. C. Scanio, Yihong Fan, Michael R. Schrimpf, Philip R. Kym, Timothy A. Vortherms, Andrew M. Swensen, Bo Liu, Arlene M. Manelli, Ying Jia, Xueqing Wang, Chris Tse, Andrew Bogdan, Ashvani K. Singh
Publikováno v:
ACS Med Chem Lett
[Image: see text] Cystic fibrosis (CF) is a genetic disorder that affects multiple tissues and organs. CF is caused by mutations in the CFTR gene, resulting in insufficient or impaired cystic fibrosis transmembrane conductance regulator (CFTR) protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418648a24d9417696c73d206f53310b2
https://doi.org/10.1021/acsmedchemlett.9b00377
https://doi.org/10.1021/acsmedchemlett.9b00377
Autor:
Meena V. Patel, Hillary M. Peltier, Mark A. Matulenko, John R. Koenig, Marc J. C. Scanio, Rebecca J. Gum, Odile F. El-Kouhen, Meagan M. Fricano, Greta L. Lundgaard, Torben Neelands, Xu-Feng Zhang, Cenchen Zhan, Madhavi Pai, Nayereh Ghoreishi-Haack, Thomas Hudzik, Gary Gintant, Ruth Martin, Steve McGaraughty, Jun Xu, Daniel Bow, John C. Kalvass, Philip R. Kym, David A. DeGoey, Michael E. Kort
Publikováno v:
Bioorganic & Medicinal Chemistry. 63:116743
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9360aff00f3964aaceb6096c8ef6bab3
https://doi.org/10.1016/j.bmc.2022.116743
https://doi.org/10.1016/j.bmc.2022.116743
Autor:
Brett Antonio, Robert J. Gregg, Gricelda H. Simler, Matthew S Johnson, Yi Liu, Dong Liu, Marc J. C. Scanio, Prisca Honore, Alison Knox, James B. Thomas, Shailen K. Joshi, Mark L. Chapman, Brian E. Marron, Irene Drizin, Douglas S. Krafte, Connie R. Faltynek, Robert N. Atkinson, Xu-Feng Zhang, Michael J. Krambis, Kort Michael E, Michael F. Jarvis, Stephen Werness, Kennan C. Marsh, Lei Shi, Char-Chang Shieh
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:7816-7825
Na(v)1.8 (also known as PN3) is a tetrodotoxin-resistant (TTx-r) voltage-gated sodium channel (VGSC) that is highly expressed on small diameter sensory neurons. It has been implicated in the pathophysiology of inflammatory and neuropathic pain, and w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebd1fee852efa5ef6ea85bd394f0b15
https://doi.org/10.1016/j.bmc.2010.09.057
https://doi.org/10.1016/j.bmc.2010.09.057
Autor:
Rosemarie Roeloffs, Stephen Werness, Brian E. Marron, Chengmin Zhong, Brett Antonio, Ahmed H. Hakeem, Irene Drizin, Char-Chang Shieh, Mark L. Chapman, Joseph P. Mikusa, Marc J. C. Scanio, James B. Thomas, Shailen K. Joshi, Dong Liu, Mark A. Matulenko, Douglas S. Krafte, Robert N. Atkinson, Lei Shi, Kennan C. Marsh, Gricelda H. Simler, Matthew S Johnson, Michael J. Krambis, Kort Michael E, Michael F. Jarvis, Xu-Feng Zhang, Robert J. Gregg, Connie R. Faltynek, Matthew A. Secrest, Prisca Honore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6812-6815
A series of aryl-substituted nicotinamide derivatives with selective inhibitory activity against the Na(v)1.8 sodium channel is reported. Replacement of the furan nucleus and homologation of the anilide linker in subtype-selective blocker A-803467 (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0d6b9da5e44daf33aabb753a354c07
https://doi.org/10.1016/j.bmcl.2010.08.121
https://doi.org/10.1016/j.bmcl.2010.08.121
Autor:
Jennifer M. Frost, Marc J. C. Scanio, Jens Halvard Grønlien, Jianguo Ji, Tao Li, Kirsten Thorin-Hagene, William H. Bunnelle, Hilde Ween, David J. Anderson, Lei Shi, Michael Meyer, Tino Dyhring, Karin R. Tietje, Dan Peters
Publikováno v:
Journal of Medicinal Chemistry. 52:4126-4141
A series of 5-(pyridine-3-yl)octahydropyrrolo[3,4-c]pyrroles have been prepared that exhibit high affinity to alpha4beta2 and/or alpha7 nicotinic acetylcholine receptors (nAChRs). Simple substitution patterns have been identified that allow construct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95edc1f13156802b50953a488364939
https://doi.org/10.1021/jm900249k
https://doi.org/10.1021/jm900249k
Publikováno v:
Current Topics in Medicinal Chemistry. 9:362-376
The voltage-gated sodium channels are a family of proteins that control the flow of sodium ions across cell membranes. Considerable data support the hypothesis that hyperexcitability and spontaneous action potential firing in peripheral sensory neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ad1ace59d9b19415cc2389e1f7fd55
https://doi.org/10.2174/156802609788317883
https://doi.org/10.2174/156802609788317883
Autor:
Matthew S Johnson, Dong Liu, Robert J. Gregg, Irene Drizin, Michael F. Gross, Gricelda Hernandez, Kennan C. Marsh, James B. Thomas, Mark L. Chapman, Chang Z. Zhu, Brian E. Marron, Connie R. Faltynek, Shailen K. Joshi, Prisca Honore, Stephen Werness, Michael E. Kort, Douglas S. Krafte, Robert N. Atkinson, Rosemarie Roeloffs, William A. Carroll, Marc J. C. Scanio, Xu-Feng Zhang, Donna M. Gauvin, Michael J. Krambis, Michael F. Jarvis, Char-Chang Shieh, Lei Shi, Joseph P. Mikusa
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6379-6386
The synthesis and pharmacological characterization of a novel furan-based class of voltage-gated sodium channel blockers is reported. Compounds were evaluated for their ability to block the tetrodotoxin-resistant sodium channel Na(v)1.8 (PN3) as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdfd333e1e1c8103d37b0c3b7e0a15f
https://doi.org/10.1016/j.bmc.2008.05.003
https://doi.org/10.1016/j.bmc.2008.05.003
Autor:
William A Carroll, Chengmin Zhong, Stephen Werness, Jinrong Liu, Matthew S Johnson, Lei Shi, Michael F Jarvis, James B. Thomas, Xu-Feng Zhang, Mark L. Chapman, Michael F. Gross, Shailen Joshi, Michael E. Kort, Marc J. C. Scanio, Dong Liu, Robert J Gregg, Rosemarie Roeloffs, Prisca Honore, Gricelda Hernandez, Gregory J Pacofsky, Douglas S. Krafte, Robert N. Atkinson, Brian E. Marron, Irene I. Drizin, Kennan C Marsh, Joseph P Mikusa, Michael J. Krambis, Bernard P Murray, Char-Chang Shieh, Connie R. Faltynek
Publikováno v:
Journal of Medicinal Chemistry. 51:407-416
Nav1.8 (also known as PN3) is a tetrodotoxin-resistant (TTx-r) voltage-gated sodium channel (VGSC) that is highly expressed on small diameter sensory neurons and has been implicated in the pathophysiology of inflammatory and neuropathic pain. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4dee5ae6db88bda78289080d9f0fe12
https://doi.org/10.1021/jm070637u
https://doi.org/10.1021/jm070637u