Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Marc Issandou"'
Autor:
François Briand, Morgan Tréguier, Agnès André, Didier Grillot, Marc Issandou, Khadija Ouguerram, Thierry Sulpice
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 4, Pp 763-770 (2010)
Liver X receptor (LXR) activation promotes reverse cholesterol transport (RCT) in rodents but has major side effects (increased triglycerides and LDL-cholesterol levels) in species expressing cholesteryl ester transfer protein (CETP). In the face of
Externí odkaz:
https://doaj.org/article/f76eb481b98d44298bd7f909cd523ecf
Autor:
Jean-Marie Brusq, Nicolas Ancellin, Pascal Grondin, Raphaelle Guillard, Sandrine Martin, Yannick Saintillan, Marc Issandou
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 6, Pp 1281-1288 (2006)
The alkaloid drug berberine (BBR) was recently described to decrease plasma cholesterol and triglycerides (TGs) in hypercholesterolemic patients by increasing expression of the hepatic low density lipoprotein receptor (LDLR). Using HepG2 human hepato
Externí odkaz:
https://doaj.org/article/0365268ae49845cba0188a5a5c29f6eb
Autor:
Jessie Zhang, Nicole Dudley-Rucker, Jan R. Crowley, Elvira Lopez-Perez, Marc Issandou, Jean E. Schaffer, Daniel S. Ory
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 2, Pp 223-231 (2004)
Recently, a new class of lipid-lowering agents has been described that upregulate LDL receptor (LDLr) activity. These agents are proposed to activate sterol-regulated gene expression through binding to the sterol regulatory element binding protein (S
Externí odkaz:
https://doaj.org/article/332d974bf5394121a4534479f154607b
Autor:
Morgan Tréguier, Didier Grillot, Marc Issandou, François Briand, Agnès André, Khadija Ouguerram, Thierry Sulpice
Publikováno v:
The Journal of Lipid Research; Vol 51
Journal of Lipid Research, Vol 51, Iss 4, Pp 763-770 (2010)
Journal of Lipid Research, Vol 51, Iss 4, Pp 763-770 (2010)
Liver X receptor (LXR) activation promotes reverse cholesterol transport (RCT) in rodents but has major side effects (increased triglycerides and LDL-cholesterol levels) in species expressing cholesteryl ester transfer protein (CETP). In the face of
Autor:
Matthew J. McVey, Jeffrey J. Legos, Didier Grillot, R. F. White, Jean-Marie Brusq, Marc Issandou, Michael K. Hansen, Frank C. Barone
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 15:196-202
Cholesteryl ester transfer protein (CETP) plays a key role in high-density lipoprotein (HDL) cholesterol metabolism, but normal mice are deficient in CETP. In this study, transgenic mice expressing both human apolipoprotein B 100 (ApoB-100) and human
Autor:
Marie-Claire Forest, Jean-Marie Brusq, Thierry Sulpice, Christelle Michiels, Didier Grillot, Marc Issandou, Raphaelle Guillard, Sandrine Martin, Anne Marie Jeanne Bouillot, Alain Claude-Marie Daugan
Publikováno v:
European Journal of Pharmacology. 618:28-36
Stearoyl-CoA Desaturase 1 (SCD1) is a central enzyme that catalyzes the biosynthesis of monounsaturated fatty acids from saturated fatty acids. SCD1 is an emerging target in obesity and insulin resistance due to the improved metabolic profile obtaine
Autor:
Hervé Coste, Marie-Hélène Fouchet, Frédéric Donche, Sylvie Demaria Magny, Florent Potvain, M Walker, Marc Issandou, Nerina Dodic, Anne-Benedicte Boullay, Anne Marie Jeanne Bouillot, Christophe Junot, Christelle Martin
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6218-6232
We describe the discovery of novel potent inhibitors of 2,3-oxidosqualene:lanosterol cyclase inhibitors (OSCi) from a focused pharmacophore-based screen. Optimization of the most tractable hits gave a series of compounds showing inhibition of cholest
Autor:
Daniel S. Ory, Elvira Lopez-Perez, Jan R. Crowley, Jessie Zhang, Nicole Dudley-Rucker, Marc Issandou, Jean E. Schaffer
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 2, Pp 223-231 (2004)
Recently, a new class of lipid-lowering agents has been described that upregulate LDL receptor (LDLr) activity. These agents are proposed to activate sterol-regulated gene expression through binding to the sterol regulatory element binding protein (S
Autor:
Anne Marie Jeanne Bouillot, Aurélie Perrot, M Walker, Thierry Grand-Perret, Stéphane Commans, Marc Issandou
Publikováno v:
Nature Medicine. 7:1332-1338
Upregulation of low-density lipoprotein receptor (LDLr) is a key mechanism to control elevated plasma LDL-cholesterol levels. Here we identify a new class of compounds that directly binds to the sterol regulatory element-binding protein (SREBP) cleav
Autor:
Marc Issandou, Thierry Grand-Perret
Publikováno v:
Biochemical and Biophysical Research Communications. 279:369-377
The aim of the present paper is to reinvestigate the role of multidrug resistance P-glycoprotein MDR1 and MDR-associated protein (MRP1) in cholesterol esterification using well-characterized inhibitors. Using specific substrate efflux assay, we show