Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Marc Hennequart"'
Autor:
Marc Hennequart, Christiaan F. Labuschagne, Mylène Tajan, Steven E. Pilley, Eric C. Cheung, Nathalie M. Legrave, Paul C. Driscoll, Karen H. Vousden
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Cancer cells in culture are often grown in media conditions containing unphysiological metabolite levels. Here, the authors grow cells under physiological metabolite levels to further understand the reliance of cells on serine and find that when grow
Externí odkaz:
https://doaj.org/article/d92cf3d95d89487c9cc004996a158731
Autor:
Mylène Tajan, Marc Hennequart, Eric C. Cheung, Fabio Zani, Andreas K. Hock, Nathalie Legrave, Oliver D. K. Maddocks, Rachel A. Ridgway, Dimitris Athineos, Alejandro Suárez-Bonnet, Robert L. Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian S. W. Li, Georgios Vlachogiannis, Nicola Valeri, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, Karen Blyth, Owen J. Sansom, Karen H. Vousden
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Dietary serine and glycine starvation has emerged as a potential therapy for cancer. Here, the authors show that inhibition of PHGDH, which mediates the first step in the serine synthesis pathway, improves the therapeutic efficacy of serine depletion
Externí odkaz:
https://doaj.org/article/4b3a136e97e9418588502ed7dece3071
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Regulatory T cells (Tregs) are essential for mitigating inflammation. Tregs are found in nearly every tissue and play either beneficial or harmful roles in the host. The availability of various nutrients can either enhance or impair Treg function. Mi
Externí odkaz:
https://doaj.org/article/ec53933c9b7c4987bb87980df10b480e
Autor:
Julianna Blagih, Fabio Zani, Probir Chakravarty, Marc Hennequart, Steven Pilley, Sebastijan Hobor, Andreas K. Hock, Josephine B. Walton, Jennifer P. Morton, Eva Gronroos, Susan Mason, Ming Yang, Iain McNeish, Charles Swanton, Karen Blyth, Karen H. Vousden
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 481-496.e6 (2020)
Summary: Loss of p53 function contributes to the development of many cancers. While cell-autonomous consequences of p53 mutation have been studied extensively, the role of p53 in regulating the anti-tumor immune response is still poorly understood. H
Externí odkaz:
https://doaj.org/article/9e8f02a81ba8423a9ff553a069bb7e18
Autor:
Nathalie Arts, Stefania Cané, Marc Hennequart, Juliette Lamy, Guido Bommer, Benoît Van den Eynde, Etienne De Plaen
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122517 (2015)
Loss of expression of surface antigens represents a significant problem for cancer immunotherapy. Microphthalmia-associated transcription factor (MITF-M) regulates melanocyte fate by driving expression of many differentiation genes, whose protein pro
Externí odkaz:
https://doaj.org/article/6d344dfb97f2435a8e08e4895c2687fc
Autor:
Benoît J. Van den Eynde, Etienne De Plaen, Vincent Stroobant, Delia Hoffmann, Stefania Cane, Luc Pilotte, Marc Hennequart
Treatment of SKOV3 cells with celecoxib represses IDO1 expression and tryptophan degradation, and restores proliferation of co-incubated allogeneic lymphocytes (PBL).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d05bdcb51c73b274bb926f773f2f1d5
https://doi.org/10.1158/2326-6066.22539946.v1
https://doi.org/10.1158/2326-6066.22539946.v1
Autor:
Benoît J. Van den Eynde, Etienne De Plaen, Vincent Stroobant, Delia Hoffmann, Stefania Cane, Luc Pilotte, Marc Hennequart
Tumors use various mechanisms to avoid immune destruction. Cyclooxygenase-2 (COX-2) expression may be a driver of immune suppression in melanoma, but the mechanisms involved remain elusive. Here, we show that COX-2 expression drives constitutive expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aac0170bf4d23543e94a808b16b1481
https://doi.org/10.1158/2326-6066.c.6549235
https://doi.org/10.1158/2326-6066.c.6549235
Autor:
Benoît J. Van den Eynde, Etienne De Plaen, Vincent Stroobant, Delia Hoffmann, Stefania Cane, Luc Pilotte, Marc Hennequart
Human tumor cell lines used in this study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287dc683c1ef6fc5b1d9b7351b3ea65f
https://doi.org/10.1158/2326-6066.22539943.v1
https://doi.org/10.1158/2326-6066.22539943.v1
Autor:
Marc Hennequart, Steven E. Pilley, Christiaan F. Labuschagne, Jack Coomes, Loic Mervant, Paul C. Driscoll, Nathalie M. Legrave, Younghwan Lee, Peter Kreuzaler, Benedict Macintyre, Yulia Panina, Julianna Blagih, David Stevenson, Douglas Strathdee, Deborah Schneider-Luftman, Eva Grönroos, Eric C. Cheung, Mariia Yuneva, Charles Swanton, Karen H. Vousden
Publikováno v:
Cell Reports. 42:112562
Mitochondrial 10-formyltetrahydrofolate (10-formyl-THF) is utilized by three mitochondrial enzymes to produce formate for nucleotide synthesis, NADPH for antioxidant defense, and formyl-methionine (fMet) to initiate mitochondrial mRNA translation. On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfe85ed56011de1083c9efab2c68d8b
https://doi.org/10.1016/j.celrep.2023.112562
https://doi.org/10.1016/j.celrep.2023.112562
Autor:
Vipin Suri, Mylène Tajan, Owen J. Sansom, Vivian S. W. Li, Rachel A. Ridgway, Laura Novellasdemunt, Eric C. Cheung, Robert L. Ludwig, Marc Hennequart, Nathalie Legrave, Nicola Valeri, Georgios Vlachogiannis, Fabio Zani, Andreas K. Hock, Alejandro Suárez-Bonnet, Nello Mainolfi, Karen Blyth, Mark Manfredi, Adam L. Friedman, Nikolaos Angelis, Karen H. Vousden, Oliver D. K. Maddocks, Dimitris Athineos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Many tumour cells show dependence on exogenous serine and dietary serine and glycine starvation can inhibit the growth of these cancers and extend survival in mice. However, numerous mechanisms promote resistance to this therapeutic approach, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f606433f50b018c4e02014a01e9a1511
https://doaj.org/article/4b3a136e97e9418588502ed7dece3071
https://doaj.org/article/4b3a136e97e9418588502ed7dece3071