Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Marc Heijn"'
Autor:
George L. Scheffer, Jan Lankelma, Rik J. Scheper, H. J. Broxterman, Jan Hendrik Hooijberg, H.M. Pinedo, Marc Heijn, M C de Jong, C. Vrasdonk
Publikováno v:
Hooijberg, J H, Broxterman, H J, Scheffer, G L, Vrasdonk, C, Heijn, M, de Jong, M C, Scheper, R J, Lankelma, J & Pinedo, H M 1999, ' Potent interaction of flavopiridol with MRP1 ', British Journal of Cancer, vol. 81, pp. 269-276 . https://doi.org/10.1038/sj.bjc.6690687
British Journal of Cancer, 81, 269-276. Nature Publishing Group
British Journal of Cancer
British Journal of Cancer, 81, 269-276. Nature Publishing Group
British Journal of Cancer
The multidrug resistance protein 1 (MRP1) is an ATP-dependent transport protein for organic anions, as well as neutral or positively charged anticancer agents. In this study we show that flavopiridol, a synthetic flavonoid currently studied in phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d324373a2e76b3bbe739709ba424b474
https://doi.org/10.1038/sj.bjc.6690687
https://doi.org/10.1038/sj.bjc.6690687
Publikováno v:
Analytical Biochemistry, 263, 221-231. Academic Press Inc.
Wielinga, P W, Heijn, M, Westerhoff, H V & Lankelma, J 1998, ' A method for studying plasma membrane transport with intact cells using computerized fluorometry. ', Analytical Biochemistry, vol. 263, pp. 221-231 . https://doi.org/10.1006/abio.1998.2779
Wielinga, P W, Heijn, M, Westerhoff, H V & Lankelma, J 1998, ' A method for studying plasma membrane transport with intact cells using computerized fluorometry. ', Analytical Biochemistry, vol. 263, pp. 221-231 . https://doi.org/10.1006/abio.1998.2779
A new method is presented for measuring rapid efflux of fluorescent compounds from monolayer cells. Cells grown on a glass coverslip were loaded with a fluorescent substrate. Thereafter, the coverslip was installed outside the light path in a stirred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92da1277f19da01050533627824b700e
https://hdl.handle.net/1871/24703
https://hdl.handle.net/1871/24703
Autor:
Jan Lankelma, D.L.A Fles, Marc Heijn, Herbert M. Pinedo, Jan Hendrik Hooijberg, H. J. Broxterman
Publikováno v:
FEBS Letters. 413:344-348
The multidrug resistance protein (MRP) is an ATP-dependent transport protein for organic anions, as well as neutral or positively charged anticancer agents. In this study we report that dinitrophenyl-S-glutathione increases ATPase activity in plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7640c94a42df21919bd7db23cf64f5d
https://doi.org/10.1016/s0014-5793(97)00940-x
https://doi.org/10.1016/s0014-5793(97)00940-x
Autor:
Jan Lankelma, Hans V. Westerhoff, George L. Scheffer, Jan Hendrik Hooijberg, Gábor Szabó, Marc Heijn
Publikováno v:
Heijn, M, Hooijberg, J H, Scheffer, G L, Szabó, G, Westerhoff, H V & Lankelma, J 1997, ' Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport ', Biochimica et Biophysica Acta. Biomembranes, vol. 1326, pp. 12-22 . https://doi.org/10.1016/S0005-2736(97)00003-5
Biochimica et Biophysica Acta. Biomembranes, 1326, 12-22. Elsevier
Biochimica et Biophysica Acta. Biomembranes, 1326, 12-22. Elsevier
We studied the ATP-dependent uptake of dinitrophenyl-glutathione (GS-DNP) into plasma membrane vesicles derived from parental GLC4 cells and from multidrug resistant GLC4/ADR cells. The latter have a high expression of the multidrug resistance protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663cb65b91fad9b8eb4c676ded86c2e3
https://doi.org/10.1016/s0005-2736(97)00003-5
https://doi.org/10.1016/s0005-2736(97)00003-5
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 343:102-107
The effect of substituted benzoates on the transport of p-aminohippurate (PAH) was studied in basolateral (BLMV) and brush border membrane vesicles (BBMV) isolated from dog kidney cortex. For both membranes, kinetic analysis of [3H]PAH transport in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb3a2b850122b22642add205562986a
https://doi.org/10.1007/bf00180684
https://doi.org/10.1007/bf00180684
Autor:
Jan Lankelma, Judith C.C. Beers, Marc Heijn, Yvette van Hensbergen, Henk J. Broxterman, Epie Boven, Yvonne W. Elderkamp, Klaas Hoekman, Herbert M. Pinedo
Publikováno v:
Biochemical pharmacology. 63(5)
There is increasing interest in the exploitation of molecular addresses for the targeting of tumor imaging or therapeutic agents. A recent study demonstrated anticancer activity in human xenografts of doxorubicin (DOX)–peptide conjugates targeted t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3845028ae1f1153564f89737d95379f
https://pubmed.ncbi.nlm.nih.gov/11911842
https://pubmed.ncbi.nlm.nih.gov/11911842
Publikováno v:
Journal of the National Cancer Institute. 88(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cb58476e3b0ed4e671747b00bc6e0f
https://pubmed.ncbi.nlm.nih.gov/8618244
https://pubmed.ncbi.nlm.nih.gov/8618244
Publikováno v:
European Journal of Pharmacology. 183:1158-1159
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd563626806a72c4f3448a19ff8d93dd
https://doi.org/10.1016/0014-2999(90)94246-t
https://doi.org/10.1016/0014-2999(90)94246-t
Autor:
Wim G. Vermeulen, Carel H. van Os, Peter E.M. van der Linden, Marc Heijn, Cees A.M. van Ginneken, Frans G. M. Russel
Publikováno v:
Biochemical pharmacology. 37(13)
The transport of p -aminohippurate (PAH) was studied in basolateral (BLMV) and brush border membrane vesicles (BBMV) isolated from dog kidney cortex. Imposition of an inwardly directed 100 mN Na + gradient stimulated the uptake of 50 μM [ 3 H]PAH in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d93165ecb38a6fb23952203ed963be
https://pubmed.ncbi.nlm.nih.gov/3390224
https://pubmed.ncbi.nlm.nih.gov/3390224