Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Marc H. Towle"'
Publikováno v:
Journal of Combinatorial Chemistry. 8:705-714
In this paper, we report the development of a mass-directed supercritical fluid chromatography (SFC) purification system. We have addressed issues on software compatibility, the interface between the preparative SFC and the mass spectrometer, and fra
Publikováno v:
Journal of Chromatography A. 1119:147-155
In this paper we report a systematic recovery study based on reversed phase high performance liquid chromatography (RP-HPLC) separation and mass spectrometric (MS) based fractionation. Factors including a compound's physicochemical properties, column
Autor:
Marc H. Towle, Peter W. Tidswell, Annette S. Fang, Wolfgang Goetzinger, James N. Kyranos, Xiusheng Miao
Publikováno v:
Mass spectrometry reviews. 27(1)
In this Section, we review the applications of mass spectrometry for the analysis and purification of new chemical entities (NCEs) for pharmaceutical discovery. Since the speed of synthesis of NCEs has dramatically increased over the last few years,