Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Marc Grundl"'
Autor:
Tânia F. Custódio, Maxime Killer, Dingquan Yu, Virginia Puente, Daniel P. Teufel, Alexander Pautsch, Gisela Schnapp, Marc Grundl, Jan Kosinski, Christian Löw
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract PHT1 is a histidine /oligopeptide transporter with an essential role in Toll-like receptor innate immune responses. It can act as a receptor by recruiting the adaptor protein TASL which leads to type I interferon production via IRF5. Persist
Externí odkaz:
https://doaj.org/article/4be3f59ad2c440dca63059f50336a519
Autor:
Tânia Custódio, Maxime Killer, Dingquan Yu, Virginia Puente, Daniel Teufel, Alexander Pautsch, Gisela Schnapp, Marc Grundl, Jan Kosinski, Christian Loew
PHT1 is a histidine /oligopeptide transporter with an essential role in Toll-like receptor innate immune response. It can act as a receptor by recruiting the adaptor protein TASL which leads to type I interferon production via IRF5. Persistent stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3bcd275d43c4c1358e8c8fabc20a370
https://doi.org/10.21203/rs.3.rs-2646698/v1
https://doi.org/10.21203/rs.3.rs-2646698/v1
Autor:
Andreas Gollner, Markus Köster, Paul Nicklin, Thomas Trieselmann, Elliott Klein, Jaromir Vlach, Claudia Heine, Marc Grundl, Jürgen Ramharter, David Wyatt, Menorca Chaturvedi, Alessio Ciulli, Katharine C. Carter, Susanne Müller, Daniel Bischoff, Peter Ettmayer, Eric Haaksma, Jürgen Mack, Darryl McConnell, Dirk Stenkamp, Harald Weinstabl, Matthias Zentgraf, Clive R. Wood, Florian Montel
Publikováno v:
Nature reviews. Drug discovery. 21(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0532092410ea682f9e1120d72a6dd5c
https://pubmed.ncbi.nlm.nih.gov/35459938
https://pubmed.ncbi.nlm.nih.gov/35459938
Publikováno v:
Journal of Computer-Aided Molecular Design. 35:531-539
Drug discovery is an expensive and time-consuming process. To make this process more efficient quantum chemistry methods can be employed. The electrophilicity index is one property that can be calculated by quantum chemistry methods, and if calculate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eb68618c4c32c6b9275a019d3fcf64a
https://doi.org/10.1007/s10822-020-00342-w
https://doi.org/10.1007/s10822-020-00342-w
Autor:
Alexander Pautsch, Alexander Weber, Christofer S. Tautermann, Ferruccio Palazzesi, Marc Grundl
Publikováno v:
Journal of Chemical Information and Modeling. 59:3565-3571
Thanks to their unique mode of action, covalent drugs represent an exceptional opportunity for drug design. After binding to a biologically relevant target system, covalent compounds form a reversible or irreversible covalent bond with a nucleophilic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101d39a767b2957ab2d1a2cdaed7d061
https://doi.org/10.1021/acs.jcim.9b00316
https://doi.org/10.1021/acs.jcim.9b00316
Autor:
Ferruccio Palazzesi, Alexander Weber, Alexander Pautsch, Christofer S. Tautermann, Marc Grundl, Markus R. Hermann, Daniel Seeliger
Publikováno v:
Journal of chemical information and modeling. 60(6)
In the past decade, the pharmaceutical industry has paid closer attention to covalent drugs. Differently from standard noncovalent drugs, these compounds can exhibit peculiar properties, such as higher potency or longer duration of target inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d86b93e5c58747b4cf56c01a3fae08
https://pubmed.ncbi.nlm.nih.gov/32250627
https://pubmed.ncbi.nlm.nih.gov/32250627
Autor:
Stefan Kreideweiss, Adrian Schreiber, Peter Eickholz, Katrin Nickles, Anthony Rousselle, Uwe Jerke, Brice Korkmaz, Marc Grundl, Ralph Kettriz, Claudia Eulenberg-Gustavus
Publikováno v:
Rheumatology. 58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2041525dfc8f5304f8e461185d6ad95
https://doi.org/10.1093/rheumatology/kez061.011
https://doi.org/10.1093/rheumatology/kez061.011
Autor:
Florian Montel, Gisela Schnapp, Ralf Heilker, Supriyo Bhattacharya, Christofer S. Tautermann, Scott Hobson, Sven Thamm, Christian Eickmeier, Dennis Fiegen, Frank H. Büttner, Ulrike Gross, Nagarajan Vaidehi, Stefan Hoerer, Volker Mack, Marc Grundl, Markus Zeeb, Stefan Peters, Andreas H. Luippold, Florian Binder
Publikováno v:
Journal of medicinal chemistry. 62(1)
Protein tyrosine phosphatase non-receptor type 5 (PTPN5, STEP) is a brain specific phosphatase that regulates synaptic function and plasticity by modulation of N-methyl-d-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9ae75015aa01170c721b74c0bcca15
https://pubmed.ncbi.nlm.nih.gov/30207464
https://pubmed.ncbi.nlm.nih.gov/30207464
Autor:
Holger Rosenbrock, Eliza Koros, Scott Hobson, Klaus G. Reymann, Gert Kramer, Ulrich H. Schröder, Marc Grundl, Matthias Grauert
Publikováno v:
European Journal of Pharmacology. 639:40-46
The NMDA (N-methyl-D-aspartate)-receptor is fundamentally involved in cognitive functions. Recent studies demonstrated a functional interaction between the metabotropic glutamate receptor 5 (mGlu(5) receptor) and the NMDA-receptor in neurons. In rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5e1370737156049370435268d60b80
https://doi.org/10.1016/j.ejphar.2010.02.057
https://doi.org/10.1016/j.ejphar.2010.02.057