Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Marc G. Wathelet"'
Autor:
Yohannes A. Mebratu, Ivan Leyva-Baca, Marc G. Wathelet, Neal Lacey, Hitendra S. Chand, Augustine M. K. Choi, Yohannes Tesfaigzi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Bcl-2 interacting killer (Bik) decreases airway epithelial hyperplasia via apoptosis mediated by calcium release from the endoplasmic reticulum (ER), but the mechanism is unclear. Here the authors show that Bik promotes Bak enrichment at the ER to te
Externí odkaz:
https://doaj.org/article/763e7af1c632449592822f6a9fa2b319
Autor:
Steven A. Belinsky, Frank D. Gilliland, Marc G. Wathelet, Yong Lin, James A. Swenberg, Yushi Liu, Christine A. Stidley, Richard E. Crowell, Shantu G. Amin, Dhimant Desai, Daniel E. Juri, Xiequn Zhang, Maria A. Picchi, Andrew R. Jauregui, Carmen S. Tellez, Cynthia L. Thomas, Leonard B. Collins, Guodong Wu, Shuguang Leng
Supplementary Table 1. Characteristics of study subjects in LSC and VSC Supplementary Table 2. Common SNPs associated with risk for MGMT methylation in LSC GWAS discovery with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1b4fea5af204471b2e3cd3483d8fb8
https://doi.org/10.1158/0008-5472.22405395.v1
https://doi.org/10.1158/0008-5472.22405395.v1
Autor:
Neal Lacey, Ivan Leyva-Baca, Hitendra S. Chand, Augustine M.K. Choi, Marc G. Wathelet, Yohannes A. Mebratu, Yohannes Tesfaigzi
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Bik reduces hyperplastic epithelial cells by releasing calcium from endoplasmic reticulum stores and causing apoptosis, but the detailed mechanisms are not known. Here we report that Bik dissociates the Bak/Bcl-2 complex to enrich for ER-associated B
Autor:
Jialing Xiang, Yohannes A. Mebratu, J.T. Jones, Chunyu Zhang, Yohannes Tesfaigzi, Christopher M. Evans, Marc G. Wathelet, Hitendra S. Chand, Burton F. Dickey
Publikováno v:
Mucosal immunology
IFN-γ is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-γ rapidly induced Noxa expression and that extent of inflammation
Autor:
Jeffrey A. Haspel, Xiaomeng Tang, Cristobal Risquez, Andrew J. Goodwin, Ying Shi, Marc G. Wathelet, Isis E. Fernandez, Stefan W. Ryter, Juan C. Osorio, Bernadette R. Gochuico, Yuanyuan Shi, Guoying Yu, Eric M. Billings, Naftali Kaminski, Danielle Morse, Avignat Patel, Ivan O. Rosas
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 188:831-841
Alveolar transforming growth factor (TGF)-β1 signaling and expression of TGF-β1 target genes are increased in patients with idiopathic pulmonary fibrosis (IPF) and in animal models of pulmonary fibrosis. Internalization and degradation of TGF-β re
Autor:
Shuguang Leng, Yushi Liu, Christine A. Stidley, Maria A. Picchi, Shantu Amin, Carmen S. Tellez, Daniel E. Juri, Cynthia L. Thomas, Xiequn Zhang, Leonard B. Collins, Frank D. Gilliland, Marc G. Wathelet, Dhimant Desai, Yong Lin, James A. Swenberg, Guodong Wu, Richard E. Crowell, Andrew R. Jauregui, Steven A. Belinsky
O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that protects cells from carcinogenic effects of alkylating agents; however, MGMT is silenced by promoter hypermethylation during carcinogenesis. A single-nucleotide polymorphism (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c75bcabad116c26cb7e8d336fe19826
Autor:
Anna Hui, Maria F. Czyzyk-Krzeska, Justin B. Striet, Laura Conforti, David Gozal, Adriana Zakrzewska, Jennifer R. Robbins, Marc G. Wathelet, Phillip O. Schnell, Milan Petrovic
Publikováno v:
Journal of Neurochemistry. 94:1288-1296
Transcription co-activators and histone acetyltransferases, p300 and cyclic AMP responsive element-binding protein-binding protein (CBP), participate in hypoxic activation of hypoxia-inducible genes. Here, we show that exposure of PC12 and cells to 1
Publikováno v:
European Journal of Biochemistry. 271:3693-3703
The interferon-β promoter has been studied extensively as a model system for combinatorial transcriptional regulation. In virus-infected cells the transcription factors ATF-2, c-Jun, interferon regulatory factor (IRF)-3, IRF-7 and NF-κB, and the co
Publikováno v:
Journal of Biological Chemistry. 278:15495-15504
Interferon regulatory factor (IRF)-7 is activated in response to virus infection and stimulates the transcription of a set of cellular genes involved in host antiviral defense. The mechanism by which IRF-7 is activated and cooperates with other trans
Publikováno v:
European Journal of Biochemistry. 269:6142-6151
Virus infection results in the activation of a set of cellular genes involved in host antiviral defense. IRF-3 has been identified as a critical transcription factor in this process. The activation mechanism of IRF-3 is not fully elucidated, yet it i