Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Marc G, Hummersone"'
Autor:
Christopher J. Moody, William Lewis, Magdalena B. Foreiter, Marc G. Hummersone, Richard T. Wheelhouse, Helen S. Summers, David Cousin, Tracey D. Bradshaw, Malcolm F. G. Stevens, Jihong Zhang
Publikováno v:
MedChemComm. 9:545-553
A series of 3-(benzyl-substituted)-imidazo[5,1-d]-1,2,3,5-tetrazines (13) and related derivatives with 3-heteromethyl groups has been synthesised and screened for growth-inhibitory activity in vitro against two pairs of glioma cell lines with temozol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37dccf8e94ea21e104fc7ba2b4b0af63
https://doi.org/10.1039/c7md00554g
https://doi.org/10.1039/c7md00554g
Autor:
Jihong Zhang, Marc G. Hummersone, David Cousin, Mark Frigerio, Charles S. Matthews, Tracey D. Bradshaw, Malcolm F. G. Stevens
Publikováno v:
MedChemComm. 7:2332-2343
Synthetic routes to 3-substituted imidazo[5,1-d]-1,2,3,5-tetrazines structurally related to temozolomide were explored. Interaction of 4-diazoimidazole-5-carboxamide with an isocyanate afforded high product yields when the isocyanate was available in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3417c9563ac20002166b3b5e835c39ca
https://doi.org/10.1039/c6md00384b
https://doi.org/10.1039/c6md00384b
Autor:
David, Cousin, Marc G, Hummersone, Tracey D, Bradshaw, Jihong, Zhang, Christopher J, Moody, Magdalena B, Foreiter, Helen S, Summers, William, Lewis, Richard T, Wheelhouse, Malcolm F G, Stevens
Publikováno v:
MedChemComm. 9(3)
The synthesis and biological evaluation of imidazotetrazines substituted at N-3 is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::731a25fcac8a5741d6beb1c8320ca201
https://pubmed.ncbi.nlm.nih.gov/30108945
https://pubmed.ncbi.nlm.nih.gov/30108945
Autor:
Angela Maria Rizzo, Simona Artuso, Malcolm F. G. Stevens, Chiara Cingolani, Annamaria Biroccio, Manuela Porru, Carlo Leonetti, Sara Iachettini, Marc G. Hummersone, Pasquale Zizza, Erica Salvati
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
The pentacyclic acridinium salt RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino [4,3,2-kl] acridinium methosulfate, compound 1) is one of the most interesting DNA G-quadruplex binding molecules due to its high efficacy in tumor cell growth inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ad68a86fd5d62fd5ba40b0e8a9db88
http://hdl.handle.net/11573/649996
http://hdl.handle.net/11573/649996
Publikováno v:
MedChemComm. 3:1419
An efficient synthesis of 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide (nor-temozolomide) and in situ generation of the anion of nor-temozolomide from an N-3-hydroxymethyl derivative of temozolomide are reported. Alkylation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26544a67eb7c16d1e46c86fc6103f1b6
https://doi.org/10.1039/c2md20251d
https://doi.org/10.1039/c2md20251d
Autor:
Marc G. Hummersone
Publikováno v:
Molecular Cancer Therapeutics. 10:A131-A131
The pentacyclic acridinium class of small molecule telomere targeting agents have been shown to stabilise the 3'single-stranded guanine-rich telomeric overhang to fold into a G-quadruplex structure. Stabilisation of the latter is incompatible with an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c66bdb034268d7f7162f2dac31db39fe
https://doi.org/10.1158/1535-7163.targ-11-a131
https://doi.org/10.1158/1535-7163.targ-11-a131
Autor:
Malcolm F. G. Stevens, Andrew J. McCarroll, Huw El Williams, Ian Hutchinson, Marc G. Hummersone
Publikováno v:
Molecular Cancer Therapeutics. 8:C171-C171
Antitumor properties of the potent G-quadruplex ligand 3,11-difluoro-6,8, 13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) are driven by telomere uncapping events. RHPS4 has good selectivity for quadruplex DNA over duplex DNA as measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd6c3c96a10d5af3c41b14601b5d6cf4
https://doi.org/10.1158/1535-7163.targ-09-c171
https://doi.org/10.1158/1535-7163.targ-09-c171
Autor:
Charles A. Laughton, Malcolm F. G. Stevens, Paul Kerschmeier, Tracey D. Bradshaw, Jihong Zhang, Marc G. Hummersone
Publikováno v:
Molecular Cancer Therapeutics. 8:A143-A143
Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. The current standard of care for GBM patients includes surgery, radiotherapy and oral alkylating agent temozolomide (TMZ) chemotherapy. The cytotoxic activity of TMZ is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92e8f9a6b0f352ce495aae80ffc85faa
https://doi.org/10.1158/1535-7163.targ-09-a143
https://doi.org/10.1158/1535-7163.targ-09-a143
Autor:
Jonathan J. Hollick, Laurent J. M. Rigoreau, Celine Cano-Soumillac, Xiaoling Cockcroft, Nicola J. Curtin, Mark Frigerio, Bernard T. Golding, Sophie Guiard, Ian R. Hardcastle, Ian Hickson, Marc G. Hummersone, Keith A. Menear, Niall M. B. Martin, Ian Matthews, David R. Newell, Rachel Ord, Caroline J. Richardson, Graeme C. M. Smith, Roger J. Griffin
Publikováno v:
Journal of Medicinal Chemistry; Apr2007, Vol. 50 Issue 8, p1958-1972, 15p