Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Marc Fivaz"'
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Acquired drug resistance is a major challenge in the management of cancer, which underscores the need for discovery and development of novel therapeutic strategies. We report here the mechanism of the anti-cancer activity of a small coordina
Externí odkaz:
https://doaj.org/article/4134644b5c45448bb91c2e3bab582881
Autor:
Silke Vanderhaeghe, Jovan Prerad, Arun Kumar Tharkeshwar, Elien Goethals, Katlijn Vints, Jimmy Beckers, Wendy Scheveneels, Eveline Debroux, Katrien Princen, Philip Van Damme, Marc Fivaz, Gerard Griffioen, Ludo Van Den Bosch
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Valosin-containing protein (VCP) is a ubiquitously expressed type II AAA+ ATPase protein, implicated in both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This study aimed to explore the impact of the disease-causing
Externí odkaz:
https://doaj.org/article/61150bce5793479d8f52cfb7b32a5e38
Autor:
Emma Coakley-Youngs, Medhavi Ranatunga, Simon Richardson, Giulia Getti, Susan Shorter, Marc Fivaz
Publikováno v:
Biology Open, Vol 11, Iss 9 (2022)
De novo mutations (DNMs) in chromodomain helicase DNA binding protein 8 (CHD8) are associated with a specific subtype of autism characterized by enlarged heads and distinct cranial features. The vast majority of these DNMs are heterozygous loss-of-fu
Externí odkaz:
https://doaj.org/article/9de1de8e57434a19a5da6e9b5375947f
Publikováno v:
Bio-Protocol, Vol 11, Iss 23 (2021)
Primary cilia are microtubule-based sensory organelles surrounded by membrane. They can detect mechanical and chemical stimuli. The last few years have uncovered cilia as unique signaling hubs that host a number of receptors and effector molecules. T
Externí odkaz:
https://doaj.org/article/2025a22492a54a5980ec079750840061
Autor:
Ute Jungwirth, Antoinette van Weverwijk, Miriam J. Melake, Ann F. Chambers, Qiong Gao, Marc Fivaz, Clare M. Isacke
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 1 (2018)
Studying the complex mechanisms underlying breast cancer metastasis and therapy response necessitates relevant in vivo models, particularly syngeneic models with an intact immune system. Two syngeneic spontaneously metastatic sublines, D2A1-m1 and D2
Externí odkaz:
https://doaj.org/article/2a562a0101f14b86978b3d9811293f52
Autor:
Hung Thanh Nguyen, Xin Hong, Sam Tan, Qingfeng Chen, Lifang Chan, Marc Fivaz, Stephen M. Cohen, P. Mathijs Voorhoeve
Publikováno v:
Cell Reports, Vol 8, Iss 3, Pp 707-713 (2014)
Primary human cells can be transformed into tumor cells by a defined set of genetic alterations including telomerase, oncogenic RasV12, and the tumor suppressors p53 and pRb. SV40 small T (ST) is required for anchorage-independent growth in vitro and
Externí odkaz:
https://doaj.org/article/ee18232ab2bf4df9a3bb3e6eb9fad805
Autor:
Komla Sobo, Isabelle Le Blanc, Pierre-Philippe Luyet, Marc Fivaz, Charles Ferguson, Robert G Parton, Jean Gruenberg, F Gisou van der Goot
Publikováno v:
PLoS ONE, Vol 2, Iss 9, p e851 (2007)
BackgroundPathological accumulation of cholesterol in late endosomes is observed in lysosomal storage diseases such as Niemann-Pick type C. We here analyzed the effects of cholesterol accumulation in NPC cells, or as phenocopied by the drug U18666A,
Externí odkaz:
https://doaj.org/article/43679b340211428a86b4042b963ebf6f
Publikováno v:
Alzheimer's & Dementia.
Lithium is a mood stabilizer broadly used to prevent and treat symptoms of mania and depression in people with bipolar disorder (BD). Little is known, however, about its mode of action. Here, we analyzed the impact of lithium on synaptic vesicle (SV)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb37be2df5a4dae9ee3b9ab02e8b4b3
https://doi.org/10.21203/rs.3.rs-1805872/v1
https://doi.org/10.21203/rs.3.rs-1805872/v1
Autor:
Simon C. W. Richardson, Emma Coakley-Youngs, Susan A. Shorter, Medhavi Ranatunga, Marc Fivaz, Giulia Getti
CHD8 (Chromodomain Helicase DNA Binding Protein 8) is a chromatin remodeler that preferentially regulates expression of genes implicated in early development of the cerebral cortex. De novo mutations (DNMs) in CHD8 are strongly associated with a spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05ae47ceb23756ffeb19385d6240f17
https://doi.org/10.1101/2021.03.03.433829
https://doi.org/10.1101/2021.03.03.433829