Výsledky vyhledávání - "Marc F Verhagen"

Size Exclusion Chromatography with Dual Wavelength Detection as a Sensitive and Accurate Method for Determining the Empty and Full Capsids of Recombinant Adeno-Associated Viral Vectors

Autor: He Meng, Marc F Verhagen, Denise Woodcock, Claire A. Davies, Catherine R. O'Riordan, Michelle Sorrentino, Vijender Dhawan

Publikováno v: Human Gene Therapy. 33:202-212

Gene therapy has evolved over the past decade into a promising therapeutic class for treating many intractable diseases. Recombinant adeno-associated virus (AAV) is the most commonly used viral vector for delivering therapeutic genes. Independent of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ac5d74408f69641bb77f2c7c91f082
https://doi.org/10.1089/hum.2021.123

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Capillary Electrophoresis-Sodium Dodecyl Sulfate with Laser-Induced Fluorescence Detection as a Highly Sensitive and Quality Control-Friendly Method for Monitoring Adeno-Associated Virus Capsid Protein Purity

Autor: Scott Dooley, Claire A. Davies, Marc F Verhagen, Zichuan Zhang, Jeehae Park, Hannah Barrett

Publikováno v: Human gene therapy. 32(11-12)

The capsid protein purity of adeno-associated virus (AAV) is considered a critical quality attribute of AAV-based gene therapy products. However, the analytical methods currently available to monitor the viral capsid proteins, which are present in ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7824da33484aab9113294919bc82a17
https://pubmed.ncbi.nlm.nih.gov/33081515

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