Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Marc F Pelletier"'
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Water channel aquaporin 4 is required for T cell receptor mediated lymphocyte activation
Autor: Michael Nicosia, Juyeun Lee, Ashley Beavers, Danielle Kish, George W Farr, Paul R McGuirk, Marc F Pelletier, Justin D Lathia, Robert L Fairchild, Anna Valujskikh
Publikováno v: Journal of Leukocyte Biology. 113:544-554
Aquaporins are a family of ubiquitously expressed transmembrane water channels implicated in a broad range of physiological functions. We have previously reported that aquaporin 4 (AQP4) is expressed on T cells and that treatment with a small molecul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::447f8bd8b6f1c7a76c64143967d85f6a
https://doi.org/10.1093/jleuko/qiad010
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2
Aquaporin 4 inhibition alters chemokine receptor expression and T cell trafficking
Autor: Michael Nicosia, Anna Valujskikh, Paul Robert Mcguirk, Ashley Beavers, Marc F. Pelletier, George W. Farr, Satoshi Miyairi
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Aquaporins (AQPs) are water channels that mediate a variety of biological processes. However, their role in the immune system is poorly understood. We recently reported that AQP4 is expressed by naïve and memory T cells and that AQP4 blockade with a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2dbdecca698137f1c26a8ad2fb5eb0
http://link.springer.com/article/10.1038/s41598-019-43884-2
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3
The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest
Autor: Travis C. Jackson, Keri Janesko-Feldman, Marc F. Pelletier, Robert S. B. Clark, Anthony E. Kline, Mioara D. Manole, George W. Farr, Jessica Wallisch, Patrick M. Kochanek, Paul Robert Mcguirk, Ruchira M. Jha, Henry Alexander
Publikováno v: Pediatric research
Background: Cerebral edema after cardiac arrest (CA) is associated with increased mortality and unfavorable outcome in children and adults. Aquaporin-4 mediates cerebral water movement and its absence in models of ischemia improves outcome. We invest
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70265af9848c58ad07844e8890a71cb
https://doi.org/10.1038/s41390-018-0215-5
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4
Aquaporin 4 blockade improves survival of murine heart allografts subjected to prolonged cold ischemia
Autor: Naoki Kohei, Anna Valujskikh, Katayoun Ayasoufi, Michael Nicosia, Marc F. Pelletier, Ran Fan, Paul Robert Mcguirk, George W. Farr, Robert L. Fairchild
Publikováno v: American Journal of Transplantation. 18:1238-1246
Prolonged cold ischemia storage (CIS) is a leading risk factor for poor transplant outcome. Existing strategies strive to minimize ischemia-reperfusion injury in transplanted organs, yet there is a need for novel approaches to improve outcomes of mar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c233be2ab5be7b04ef614e137fcc13be
https://doi.org/10.1111/ajt.14624
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5
Functionalized Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving Outcome in Two Models of CNS Injury
Autor: Ramon Wade, Christopher H. Hall, Paul Robert Mcguirk, Jasen M. Buch, Kui Xu, George W. Farr, Amielia G. Adams, Susan Farr, Christopher A Flask, Walter F. Boron, Marc F. Pelletier, Derek L. Beahm, Joseph C. LaManna, Joshua M. Detzel
Publikováno v: Neuroscience. 404
Cerebral edema in ischemic stroke can lead to increased intracranial pressure, reduced cerebral blood flow and neuronal death. Unfortunately, current therapies for cerebral edema are either ineffective or highly invasive. During the development of cy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367c3f1735914fe54aac961cac8c2901
https://pubmed.ncbi.nlm.nih.gov/30738082
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6
Aquaporin 4 blockade alters T cell trafficking through a novel mechanism of S1PR1 regulation
Autor: Michael Nicosia, Ran Fan, Satoshi Miyairi, George W. Farr, Paul R. McGuirk, Marc F. Pelletier, Ashley Beavers, Anna Valujskikh
Publikováno v: The Journal of Immunology. 200:55.33-55.33
The water channels aquaporins mediate a variety of immune functions. We previously demonstrated that aquaporin 4 (AQP4) is expressed by CD4 and CD8 T cells and blockade of AQP4 with small molecule inhibitor AER-270/271 significantly prolongs survival
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38e2542b53ca6126f6e55b9db6e6d58b
https://doi.org/10.4049/jimmunol.200.supp.55.33
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8
Effect of Human Carbonic Anhydrase II on the Activity of the Human Electrogenic Na/HCO3 Cotransporter NBCe1-A in Xenopus Oocytes
Autor: Mark D. Parker, Christopher M. Daly, Jing Lu, Walter F. Boron, Peter M. Piermarini, Marc F. Pelletier, Harindarpal S. Gill
Publikováno v: Journal of Biological Chemistry. 281:19241-19250
Others report that carbonic anhydrase II (CA II) binds to the C termini of the anion exchanger AE1 and the electrogenic Na/HCO3 cotransporter NBCe1-A, enhancing transport. After injecting oocytes with NBCe1-A cRNA (Day 0), we measured NBC current (I(
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49dd06aec58f7120f9663aa770a54d9
https://doi.org/10.1074/jbc.m602181200
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10
The endoplasmic reticulum: integration of protein folding, quality control, signaling and degradation
Autor: Eric Chevet, John J.M. Bergeron, David Y. Thomas, Marc F. Pelletier, Pamela H. Cameron
Publikováno v: Current Opinion in Structural Biology. 11:120-124
The endoplasmic reticulum is the entry point into the secretory pathway. To acquire a correct conformation, secretory proteins encounter the endoplasmic reticulum molecular machines of folding, quality control, signaling and disposal, which function
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9508dec8c8e77cac1fe99305a4cd748e
https://doi.org/10.1016/s0959-440x(00)00168-8
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