Augmenting antibody response to EGF-depleting immunotherapy: Findings from a phase I trial of CIMAvax-EGF in combination with nivolumab in advanced stage NSCLC

Autor: Rachel Evans, Kelvin Lee, Paul K. Wallace, Mary Reid, Jason Muhitch, Askia Dozier, Circe Mesa, Patricia L. Luaces, Orestes Santos-Morales, Adrienne Groman, Carlos Cedeno, Aileen Cinquino, Daniel T. Fisher, Igor Puzanov, Mateusz Opyrchal, Christos Fountzilas, Tong Dai, Marc Ernstoff, Kristopher Attwood, Alan Hutson, Candace Johnson, Zaima Mazorra, Danay Saavedra, Kalet Leon, Agustin Lage, Tania Crombet, Grace K. Dy

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

BackgroundCIMAvax-EGF is an epidermal growth factor (EGF)-depleting immunotherapy which has shown survival benefit as a switch maintenance treatment after platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC). The primary objecti

Externí odkaz: https://doaj.org/article/a11a28ebd42a4001a4ac9b99c18aa754

Perspectives in melanoma: meeting report from the Melanoma Bridge (November 29th–1 December 1st, 2018, Naples, Italy)

Autor: Paolo A. Ascierto, Sanjiv S. Agarwala, Gerardo Botti, Alfredo Budillon, Michael A. Davies, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Silvia Formenti, Thomas F. Gajewski, Claus Garbe, Omid Hamid, Roger S. Lo, Jason J. Luke, Oliver Michielin, Giuseppe Palmieri, Laurence Zitvogel, Francesco M. Marincola, Giuseppe Masucci, Corrado Caracò, Magdalena Thurin, Igor Puzanov

Publikováno v: Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-18 (2019)

Abstract Diagnosis of melanocytic lesions, correct prognostication of patients, selection of appropriate adjuvant and systemic therapies, and prediction of response to a given therapy remain very real challenges in melanoma. Recent studies have shown

Externí odkaz: https://doaj.org/article/f27d29ec50b04d268fc157d83fd8e820

373 Phase 1/2 study of subcutaneously administered ALKS 4230, a novel engineered cytokine, as monotherapy and in combination with pembrolizumab, in patients with advanced solid tumors: ARTISTRY-2

Autor: Yan Wang, John Powderly, Marc Ernstoff, Anthony Shields, Ulka Vaishampayan, John Wrangle, Sarina Piha-Paul, Anthony Olszanski, Lei Sun, Bradley Carthon, Kelly Curtis, Ilda Bidollari, Yangchun Du, Emily Putiri, Heather Losey, Bruce Dezube

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Externí odkaz: https://doaj.org/article/1ad3ff19fadb4798b39071e0dee24631

Ipilimumab plus nivolumab for patients with metastatic uveal melanoma: a multicenter, retrospective study

Autor: Arun Singh, Richard Carvajal, Yana G Najjar, Igor Puzanov, Marc Ernstoff, Shailender Bhatia, Katy Tsai, Fei Ding, Zeynep Eroglu, Douglas Johnson, Pauline Funchain, Sunandana Chandra, Ryan Sullivan, Roma Bhatia, Kristina Navrazhina, Kelly Abbate, Barbara Durden, Song Park, Akansha Chowdhary, Jonathan Kennedy, Pankit Vachhani, Joseph Drabick, Tan Xu, Jessica Yang, Daniel Manson, John M Kirkwood, Justine Cohen, Alexander Shoushtari

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Background Uveal melanoma (UM) is the most common intraocular malignancy in adults. In contrast to cutaneous melanoma (CM), there is no standard therapy, and the efficacy and safety of dual checkpoint blockade with nivolumab and ipilimumab is not wel

Externí odkaz: https://doaj.org/article/af78c8c4442f42e39c146dd7aedcf3ad

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016

Autor: Enriqueta Felip, Josep Tabernero, Maria De Santis, Emile Voest, Mark Robson, Fatima Cardoso, Elisabeth G E de Vries, Fedro Alessandro Peccatori, Svetlana Jezdic, Giannis Mountzios, Smita Bhatia, Alexandru Eniu, Luzia Travado, Ulrich Keilholz, Jonas Bergh, Jan Buckner, Friedrich Stiefel, Ahmad Awada, Cristiana Sessa, Olivier Michielin, Marc Ernstoff, Ben Markman, Lisa Licitra, Rossana Berardi, Jill Gilbert, Lidia Schapira, Eva Schernhammer, Jeffrey S Weber, Heinz-Josef Lenz, Piotr Rutkowski, Jennifer Duff, Axel Grothey, Yuichiro Ohe, Saskia Litiere, Hans Wildiers, Christian Dittrich, Michael Kosty, Doug Pyle, Nagi El-Saghir, Jean-Pierre Lotz, Pia Österlund, Nicholas Pavlidis, Gunta Purkalne, Susana Banerjee, Jan Bogaerts, Paolo Casali, Edward Chu, Julia Lee Close, Bertrand Coiffier, Roisin Connolly, Sarah Coupland, Luigi De Petris, Don S Dizon, Linda R Duska, Martin F Fey, Nicolas Girard, Andor W J M Glaudemans, Priya K Gopalan, Stephen M Hahn, Diana Hanna, Christian Herold, Jørn Herrstedt, Krisztian Homicsko, Dennie V Jones, Lorenz Jost, Saad Khan, Alexander Kiss, Claus-Henning Köhne, Rainer Kunstfeld, Stuart Lichtman, Thomas Lion, Lifang Liu, Patrick J Loehrer, Merry Jennifer Markham, Marius Mayerhoefer, Johannes G Meran, Elizabeth Charlotte Moser, Timothy Moynihan, Torsten Nielsen, Kjell Öberg, Antonio Palumbo, Michael Pfeilstöcker, Chandrajit Raut, Scot C Remick, Roberto Salgado, Martin Schlumberger, Hans-Joachim Schmoll, Lowell Schnipper, Charles L Shapiro, Julie Steele, Cora N Sternberg, Florian Strasser, Roger Stupp, Richard Sullivan, Marcel Verheij, Everett Vokes, Jamie Von Roenn, Yosef Yarden

Publikováno v: ESMO Open, Vol 1, Iss 5 (2016)

The European Society for Medical Oncology (ESMO) and the American Society of Clinical Oncology (ASCO) are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) thanks to contribution of 64 ESMO-appointed and 32 ASCO-appointed authors. Firs

Externí odkaz: https://doaj.org/article/03442ec458e245ef83ebe8453a3f265c