HEV ORF2 protein-antibody complex deposits are associated with glomerulonephritis in hepatitis E with reduced immune status

Autor: Anne-Laure Leblond, Birgit Helmchen, Maliki Ankavay, Daniela Lenggenhager, Jasna Jetzer, Fritjof Helmchen, Hueseyin Yurtsever, Rossella Parrotta, Marc E. Healy, Amiskwia Pöschel, Enni Markkanen, Nasser Semmo, Martin Ferrié, Laurence Cocquerel, Harald Seeger, Helmut Hopfer, Beat Müllhaupt, Jérôme Gouttenoire, Darius Moradpour, Ariana Gaspert, Achim Weber

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract Hepatitis E virus (HEV) infection, one of the most common forms of hepatitis worldwide, is often associated with extrahepatic, particularly renal, manifestations. However, the underlying mechanisms are incompletely understood. Here, we repor

Externí odkaz: https://doaj.org/article/2e0acd6efb7748d6ab4fa79b0d50a92c

JNK signaling prevents biliary cyst formation through a CASPASE-8–dependent function of RIPK1 during aging

Autor: Thomas Longerich, Mihael Vucur, Hanna Honcharova-Biletska, Johannes Schmitt, Nadine T. Gaisa, Verena Keitel, Frank Tacke, Sarah Comtesse, Lena Küsgens, Mathias Heikenwalder, Roger J. Davis, Christoph Roderburg, Peter Boor, Marc E. Healy, Marta Szydlowska, Lap Kwan Chan, Enrico Focaccia, Mirco Castoldi, Achim Weber, Christian Preisinger, Tom Luedde, Friederike Böhm, Michèle Egger, Fabian Geisler, Simone Jörs, Anne T. Schneider, Yannick Boege, Katrin Müller, Johannes G. Bode, Christiane Koppe, Sven H. Loosen

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 118(12), e2007194118 (2021). doi:10.1073/pnas.2007194118
Proceedings of the National Academy of Sciences

Significance JNK signaling has been studied intensively in models of liver physiology and disease, but previous studies had focused on young mice. However, it had not been recognized that JNK plays a fundamental role in maintaining liver homeostasis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40191e6b4153326f76b4d2f1a7083f54
https://mediatum.ub.tum.de/doc/1637116/document.pdf

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

Autor: Andreas E. Moor, Noah W. Palm, Marcel R. de Zoete, Tyler Rice, Piotr Bielecki, Aaron M. Ring, Roni Nowarski, Marc E. Healy, Kisha N. Sivanathan, Ruaidhri Jackson, Jun Zhao, Abigail Jarret, Hanna Honcharova-Biletska, Ting Zhou, Coco Duizer, Manolis Roulis, Angel G. Solis, Karelia Vélez, Saskia Hartner, Rihao Qu, Joseph M. Rone, Jun Siong Low, Richard A. Flavell, Achim Weber, Esen Sefik, Yuval Kluger

Publikováno v: Cell, 180 (1)
Cell, 180(1), 50. Cell Press
Cell

Mucosal barrier immunity is essential for the maintenance of the commensal microflora and combating invasive bacterial infection. Although immune and epithelial cells are thought to be the canonical orchestrators of this complex equilibrium, here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9ca857d287c68a47a7acae2f61c832
https://doi.org/10.1016/j.cell.2020.02.004

MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice

Autor: Anna-Lena Scherr, Hanna Honcharova-Biletska, Yannick Boege, Gabriela Kalna, Karelia Vélez, Susanne Kreutzer, R. C. Schimmer, Anna Silvia Wenning, Henning Schulze-Bergkamen, Kurt Jacobs, Kathy D. McCoy, Owen J. Sansom, Laure-Alix Clerbaux, Achim Weber, Kristian Unger, Andreas E. Moor, Friederike Böhm, Andrew J. Macpherson, Andrew D. Campbell, Mohsen Malehmir, Ella Gilchrist, Mathias Heikenwalder, Mercedes Gomez de Agüero, Ann-Katrin Rodewald, Kathryn Gilroy, Lap Kwan Chan, Rossella Parrotta, Patrizia Cammareri, Jasna Jetzer, Simone Büeler, Christoph S. N. Klose, Marc E. Healy, Bruno Köhler, Michael C. Hodder

Publikováno v: Gastroenterology
Gastroenterology, 159 (1)

Background & Aims Intestinal epithelial homeostasis depends on a tightly regulated balance between intestinal epithelial cell (IEC) death and proliferation. While the disruption of several IEC death regulating factors result in intestinal inflammatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3936b54416622bcb9a12b630045b5594
https://pubmed.ncbi.nlm.nih.gov/32179094

Dual Role of the Adaptive Immune System in Liver Injury and Hepatocellular Carcinoma Development

Autor: Alina Schreder, Dirk Haller, Florian Reisinger, Kristian Unger, Achim Weber, Thomas Longerich, Jutta Schütt, Robert Geffers, Milton J. Finegold, Ana Clara Misslitz, Alina Michael, Michael P. Manns, Laura Elisa Buitrago-Molina, Silke Marhenke, Christian Könecke, Arndt Vogel, Anna Saborowski, Thomas Clavel, Marc E. Healy, Florian P. Limbourg, Jessica Endig, Mathias Heikenwalder

Publikováno v: Cancer Cell 30, 308-323 (2016)
Cancer Cell

Hepatocellular carcinoma (HCC) represents a classic example of inflammation-linked cancer. To characterize the role of the immune system in hepatic injury and tumor development, we comparatively studied the extent of liver disease and hepatocarcinoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e10552c6aeda65b1adf698d6073850f
https://doi.org/10.1016/j.ccell.2016.06.009