Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Marc E Lenburg"'
Autor:
Darlene Lu, Serkalem Demissie, Nina B Horowitz, Adam C Gower, Marc E Lenburg, Yuriy O Alekseyev, Amira I Hussein, Beth Bragdon, Yu Liu, Dana Daukss, Jack M Page, Micheal Z Webster, Jennifer J Schlezinger, Elise F Morgan, Louis C Gerstenfeld
Publikováno v:
JBMR Plus, Vol 6, Iss 2, Pp n/a-n/a (2022)
ABSTRACT Time is a central element of the sexual dimorphic patterns of development, pathology, and aging of the skeleton. Because the transcriptome is a representation of the phenome, we hypothesized that both sex and sex‐specific temporal, transcr
Externí odkaz:
https://doaj.org/article/a34c5394e9f64112932106542a502aee
Autor:
Gang Liu, Asaf Maoz, Christopher Stevenson, Mary E Reid, Avrum Spira, Marc E Lenburg, Joshua D Campbell, Carter Merenstein, Yusuke Koga, Austin Potter, Adam C Gower, Sherry Zhang, Hanqiao Liu, Sarah A Mazzilli, Jennifer Beane
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/1a370bde366f4973b623356a8d390ced
Autor:
Jennie Ong, Wim Timens, Vijay Rajendran, Arjan Algra, Avrum Spira, Marc E Lenburg, Joshua D Campbell, Maarten van den Berge, Dirkje S Postma, Anke van den Berg, Joost Kluiver, Corry-Anke Brandsma
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0183815 (2017)
BACKGROUND:Lung fibroblasts are involved in extracellular matrix homeostasis, which is mainly regulated by transforming growth factor-beta (TGF-β), and are therefore crucial in lung tissue repair and remodeling. Abnormal repair and remodeling has be
Externí odkaz:
https://doaj.org/article/a1c4e64eac584547a246520d669c54c3
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88309 (2014)
Co-expression modules are groups of genes with highly correlated expression patterns. In cancer, differences in module activity potentially represent the heterogeneity of phenotypes important in carcinogenesis, progression, or treatment response. To
Externí odkaz:
https://doaj.org/article/46772bab9ed84c9184c6e3048737ac53
Autor:
Katrina Steiling, Aran Y Kadar, Agnes Bergerat, James Flanigon, Sriram Sridhar, Vishal Shah, Q Rushdy Ahmad, Jerome S Brody, Marc E Lenburg, Martin Steffen, Avrum Spira
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5043 (2009)
Although prior studies have demonstrated a smoking-induced field of molecular injury throughout the lung and airway, the impact of smoking on the airway epithelial proteome and its relationship to smoking-related changes in the airway transcriptome a
Externí odkaz:
https://doaj.org/article/9b88ab94a8524d0dba890815560daac1
Autor:
Aravind A. Menon, Minyi Lee, Xu Ke, Rachel K. Putman, Takuya Hino, Jonathan A. Rose, Fenghai Duan, Samuel Y. Ash, Michael H. Cho, George T. O’Connor, Josée Dupuis, Hiroto Hatabu, Marc E. Lenburg, Ehab S. Billatos, Gary M. Hunninghake, the DECAMP Investigators
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-7 (2023)
Abstract Introduction Interstitial lung abnormalities (ILA) often represent early fibrotic changes that can portend a progressive fibrotic phenotype. In particular, the fibrotic subtype of ILA is associated with increased mortality and rapid decline
Externí odkaz:
https://doaj.org/article/637eb0555ac64e08a1739d727ab43d01
Autor:
Ana B. Pavel, Carly Garrison, Lingqi Luo, Gang Liu, Daniel Taub, Ji Xiao, Brenda Juan-Guardela, John Tedrow, Yuriy O. Alekseyev, Ivana V. Yang, Mark W. Geraci, Frank Sciurba, David A. Schwartz, Naftali Kaminski, Jennifer Beane, Avrum Spira, Marc E. Lenburg, Joshua D. Campbell
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) are clinically and molecularly heterogeneous diseases. We utilized clustering and integrative network analyses to elucidate roles for microRNAs (miRNAs) and miR
Externí odkaz:
https://doaj.org/article/3ab462eb96c1423b8efb64bcedd52c26
Autor:
Boting Ning, Andrew M. Tilston-Lunel, Justice Simonetti, Julia Hicks-Berthet, Adeline Matschulat, Roxana Pfefferkorn, Avrum Spira, Matthew Edwards, Sarah Mazzilli, Marc E. Lenburg, Jennifer E. Beane, Xaralabos Varelas
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-18 (2023)
Abstract Background Bronchial premalignant lesions (PMLs) are composed primarily of cells resembling basal epithelial cells of the airways, which through poorly understood mechanisms have the potential to progress to lung squamous cell carcinoma (LUS
Externí odkaz:
https://doaj.org/article/8eeb49dcba4b46ed83d733498621d057
Autor:
Joseph G. Kern, Andrew M. Tilston-Lunel, Anthony Federico, Boting Ning, Amy Mueller, Grace B. Peppler, Eleni Stampouloglou, Nan Cheng, Randy L. Johnson, Marc E. Lenburg, Jennifer E. Beane, Stefano Monti, Xaralabos Varelas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
LATS1/2 kinases are reported to be tumour suppressors in many cancers. Here the authors show that conditional deletion of LATS1/2 in the mature mouse luminal mammary epithelium leads to luminal-basal plasticity and development of basal-like carcinoma
Externí odkaz:
https://doaj.org/article/44ef2e9ad3d946d1af1096e43d649666
Publikováno v:
mSystems, Vol 7, Iss 2 (2022)
ABSTRACT Compositional and functional alterations to the gut microbiota during aging are hypothesized to potentially impact our health. Thus, determining aging-specific gut microbiome alterations is critical for developing microbiome-based strategies
Externí odkaz:
https://doaj.org/article/3fff3e65afc0452688b61c2cbe8fdc88