Comprehensive support for families with parental cancer (Family-SCOUT), evaluation of a complex intervention: study protocol for a non-randomized controlled trial

Autor: Marc Dohmen, Andrea Petermann-Meyer, Daniel Blei, Rebecca Bremen, Evamarie Brock-Midding, Manuela Brüne, Franziska Geiser, Burkhard Haastert, Sarah Maria Halbach, Christian Heuser, Steffen Holsteg, Lina Heier, Andrea Icks, Andre Karger, Joseph Montalbo, Hannah Nakata, Jens Panse, Till-Philip Rottmann, Kristina Sättler, Anja Viehmann, Markus Vomhof, Nicole Ernstmann, Tim H. Brümmendorf

Publikováno v: Trials, Vol 22, Iss 1, Pp 1-10 (2021)

Abstract Background Families with minor children affected by parental cancer are at risk of considerable emotional and organizational stress that can severely burden all family members. So far, there has been a lack of comprehensive support services

Externí odkaz: https://doaj.org/article/150005bffb184e6998de9817e7d185e9

Protocol of a randomized, double-blind, placebo-controlled, parallel-group, multicentre study of the efficacy and safety of nicotinamide in patients with Friedreich ataxia (NICOFA)

Autor: Kathrin Reetz, Ralf-Dieter Hilgers, Susanne Isfort, Marc Dohmen, Claire Didszun, Kathrin Fedosov, Jennifer Kistermann, Caterina Mariotti, Alexandra Durr, Sylvia Boesch, Thomas Klopstock, Francisco Javier Rodríguez de Rivera Garrido, Ludger Schöls, Thomas Klockgether, Massimo Pandolfo, Rudolf Korinthenberg, Philip Lavin, Geert Molenberghs, Vincenzo Libri, Paola Giunti, Richard Festenstein, Jörg B. Schulz, the EFACTS or NICOFA study group

Publikováno v: Neurological Research and Practice, Vol 1, Iss 1, Pp 1-9 (2019)

Abstract Introduction Currently, no treatment that delays with the progression of Friedreich ataxia is available. In the majority of patients Friedreich ataxia is caused by homozygous pathological expansion of GAA repeats in the first intron of the F

Externí odkaz: https://doaj.org/article/bd386c9aed904b989f26c530d6b49d63

Comprehensive support for families with parental cancer – Family-SCOUT: study protocol for the evaluation of a complex intervention

Autor: Anja Viehmann, Marc Dohmen, Kristina Sättler, Steffen Holsteg, Manuela Brüne, Andrea Icks, Sarah Halbach, Evamarie Brock-Midding, Andrea Petermann-Meyer, Hannah Nakata, Franziska Geiser, Till-Philip Rottmann, Rebecca Bremen, Tim Henrik Brümmendorf, Daniel Blei, Markus Vomhof, Nicole Ernstmann, André Karger, Lina Heier, Jens Panse, Christian Heuser, Burkhard Haastert, Joseph Montalbo

Background: Families with minor children affected by parental cancer are at risk of considerable emotional and organizational stress that can severely burden all family members. So far, there has been a lack of comprehensive support services for affe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c586dddc547bf81d556a6be16d57639
https://doi.org/10.21203/rs.3.rs-401056/v1

AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

Autor: Elena Buerova, Kei Sakamoto, Christian Preisinger, Bernhard Lüscher, Jörg Vervoorts, Mareike Bütepage, Sarah Krieg, Stephan Geley, Dipanjan Chanda, Carolina M. Pfaff, Marc Dohmen, Georgios Agalaridis, Saifeldin N. Shehata, Xiaoqing Zhu, Jan Amelang, Elisabeth Pfeiffenberger, Dietbert Neumann

Publikováno v: Nature Communications, 11(1):1032. Nature Publishing Group
Dohmen, M, Krieg, S, Agalaridis, G, Zhu, X, Shehata, S N, Pfeiffenberger, E, Amelang, J, Bütepage, M, Buerova, E, Pfaff, C M, Chanda, D, Geley, S, Preisinger, C, Sakamoto, K, Lüscher, B, Neumann, D & Vervoorts, J 2020, ' AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy ', Nature Communications, vol. 11, no. 1, 1032 . https://doi.org/10.1038/s41467-020-14812-0
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

The AMP-activated protein kinase (AMPK) is a master sensor of the cellular energy status that is crucial for the adaptive response to limited energy availability. AMPK is implicated in the regulation of many cellular processes, including autophagy. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a596c455e15e84047461fa9d0ca10bb8
https://lirias.kuleuven.be/handle/20.500.12942/716305

Studying the Role of AMPK in Autophagy

Autor: Jörg Vervoorts, Bernhard Lüscher, Marc Dohmen, Sarah Krieg

Publikováno v: Methods in Molecular Biology ISBN: 9781493975976

AMPK is an energy-sensing kinase and is required for the induction and progression of the autophagy process. In this chapter, we describe experimental approaches to study the steady state and flux of autophagy in response to AMPK activation. For this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07d397699f10c7fb1b32589e0e18273f
https://doi.org/10.1007/978-1-4939-7598-3_24