Výsledky vyhledávání - "Marc De Backer"

Akademický článek

Changes in drug load during lacosamide combination therapy: A noninterventional, observational study in German and Austrian clinical practice

Autor: Fritjof Reinhardt, Yvonne G. Weber, Thomas Mayer, Gerhard Luef, Lars Joeres, Frank Tennigkeit, Peter Dedeken, Marc De Backer, Scarlett Hellot, Thomas Lauterbach, Tanja Webers, Stephan Arnold

Publikováno v: Epilepsia Open, Vol 4, Iss 3, Pp 409-419 (2019)

Abstract Introduction Effects of antiepileptic drug (AED) load changes in patients with focal seizures have not been well evaluated. Methods SP1065 (NCT01673282) was a noninterventional, prospective, observational study conducted in a clinical practi

Externí odkaz: https://doaj.org/article/c19e3571bedb418a83c96b0c9099851e

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Effectiveness and tolerability of lacosamide as add-on therapy in patients with brain tumor–related epilepsy

Autor: Iryna Leunikava, Roberta Rudà, Marc De Backer, Jaap C. Reijneveld, Marta Maschio, Jane Chan, Robin Grant, Scarlett Hellot, Lars Joeres, Martin Glas, Caroline Houillier

Publikováno v: Epilepsia
Epilepsia, 61(4), 647-656. Wiley-Blackwell
Rudà, R, Houillier, C, Maschio, M, Reijneveld, J C, Hellot, S, De Backer, M, Chan, J, Joeres, L, Leunikava, I, Glas, M & Grant, R 2020, ' Effectiveness and tolerability of lacosamide as add-on therapy in patients with brain tumor–related epilepsy : Results from a prospective, noninterventional study in European clinical practice (VIBES) ', Epilepsia, vol. 61, no. 4, pp. 647-656 . https://doi.org/10.1111/epi.16486

Objective: To evaluate the effectiveness and tolerability of lacosamide added to one or two antiepileptic drugs (AEDs) in the treatment of patients with brain tumor–related epilepsy (BTRE), and to evaluate patients’ global impression of change an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6486c7f806cbf5c44857a6c2c3a505
https://doi.org/10.1111/epi.16486

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Long‐term safety and efficacy of lacosamide and controlled‐release carbamazepine monotherapy in patients with newly diagnosed epilepsy

Autor: Björn Steiniger-Brach, Teresa Gasalla, Victor Biton, Hans Peter Grebe, Elinor Ben-Menachem, Marc De Backer, Melissa Brock, Kiyohito Terada, Ting Li, Lori Jensen

Publikováno v: Epilepsia

Objective A large‐scale, double‐blind trial (SP0993; NCT01243177) demonstrated that lacosamide was noninferior to controlled‐release carbamazepine (carbamazepine‐CR) in terms of efficacy, and well tolerated as first‐line monotherapy in pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bac1db1f8633cdeec7f03265d44cabb
http://europepmc.org/articles/PMC6988520

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Effectiveness and tolerability of adjunctive brivaracetam in patients with focal seizures:Second interim analysis of 6-month data from a prospective observational study in Europe

Autor: Colin P. Doherty, Jakob Christensen, Bernhard J. Steinhoff, Marc De Backer, John Paul Leach, Marian Majoie, Iryna Leunikava, Scarlett Hellot

Publikováno v: Steinhoff, B J, Christensen, J, Doherty, C P, Majoie, M, De Backer, M, Hellot, S, Leunikava, I & Leach, J P 2020, ' Effectiveness and tolerability of adjunctive brivaracetam in patients with focal seizures : Second interim analysis of 6-month data from a prospective observational study in Europe ', Epilepsy Research, vol. 165, 106329 . https://doi.org/10.1016/j.eplepsyres.2020.106329
Epilepsy Research, 165:106329. Elsevier Science

Brivaracetam (BRV) is indicated for adjunctive treatment of focal (partial-onset) seizures with or without secondary generalisation in patients 4 years of age and older in the European Union (EU). An ongoing 12-month, prospective, non-interventional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d02f039344b9983882616df49c92a08
https://pure.au.dk/ws/files/220256735/1_s2.0_S0920121119305820_main.pdf

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Effects of lacosamide and carbamazepine on lipids in a randomized trial

Autor: Svetlana Dimova, Ying Zhang, Marc De Backer, Scott Mintzer, Björn Steiniger-Brach, Robert Roebling, Daya Chellun

Publikováno v: Epilepsia. 61(12)

Objective The effects of anticonvulsants on lipids are the subject of considerable concern and investigation, but there are almost no data on this issue from randomized trials. We evaluated serum lipid profiles in adults with newly diagnosed epilepsy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15c39dddd771c7a6b7fbed8e5b18001
https://pubmed.ncbi.nlm.nih.gov/33651399

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Safety and tolerability of lacosamide monotherapy in the elderly: A subgroup analysis from lacosamide trials in diabetic neuropathic pain

Autor: Konrad J. Werhahn, Jacquelyn L. Bainbridge, Edward Faught, Marc De Backer, Klaus Eckhardt, Aziz Shaibani, David Sen, Frank Tennigkeit, S. Bongardt

Publikováno v: Epilepsia Open

SummaryObjective To assess the safety profile of lacosamide monotherapy in elderly (≥65 years) subjects with diabetic neuropathic pain (DNP). Methods Of 1,863 DNP subjects in double-blind, randomized, placebo-controlled trials of lacosamide monothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17db5e2a1a9a0cd95f2c912855ad229
http://europepmc.org/articles/PMC5862116

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Changes in hormone and lipid levels in male patients with focal seizures when switched from carbamazepine to lacosamide as adjunctive treatment to levetiracetam: A small phase IIIb, prospective, multicenter, open-label trial

Autor: Frank Tennigkeit, Michael Rademacher, Christian E. Elger, Marc De Backer, Sami Elmoufti, Klaus Eckhardt, Christian Brandt, Peter Dedeken

Publikováno v: Epilepsy & Behavior. 62:1-5

Treatment with enzyme-inducing antiepileptic drugs (AEDs) such as carbamazepine (CBZ) can lead to changes in reproductive, endocrine, and lipid parameters, resulting in clinical symptoms for some patients. Previous studies indicate that these changes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af51e6545a3afcc85f5f700bac3fb97
https://doi.org/10.1016/j.yebeh.2016.05.023

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Randomized double-blind comparison of cognitive and EEG effects of lacosamide and carbamazepine

Autor: William C. Byrnes, Simon Borghs, Suzette M. LaRoche, Naymee Velez-Ruiz, Tyler J. Story, Javier Echauz, Marc De Backer, David W. Loring, Deanne Dilley, Alan Boyd, Pearce Korb, Elizabeth Webster, Peter Dedeken, Kimford J. Meador

Publikováno v: Epilepsy & Behavior. 62:267-275

Differential effectiveness of antiepileptic drugs (AEDs) is more commonly determined by tolerability than efficacy. Cognitive effects of AEDs can adversely affect tolerability and quality of life. This study evaluated cognitive and EEG effects of lac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bb06fdfd3e2b3ea63b6a722dab378a
https://doi.org/10.1016/j.yebeh.2016.07.007

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Tolerability and efficacy of lacosamide and controlled-release carbamazepine monotherapy in patients with newly diagnosed epilepsy and concomitant psychiatric conditions: Post hoc analysis of a prospective, randomized, double-blind trial

Autor: Bettina Schmitz, Ying Zhang, Teresa Gasalla, Marc De Backer, Daya Chellun, Svetlana Dimova

Publikováno v: Epilepsy Research. 159:106220

Psychiatric comorbidities are common in patients with epilepsy. A double-blind noninferiority monotherapy trial (SP0993; NCT01243177) enrolled newly diagnosed patients (≥16 years) with focal or generalized tonic-clonic seizures. Patients were rando

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769bd458106a0b58fc26b93eb81339d4
https://doi.org/10.1016/j.eplepsyres.2019.106220

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Efficacy, safety, and tolerability of lacosamide monotherapy versus controlled-release carbamazepine in patients with newly diagnosed epilepsy: a phase 3, randomised, double-blind, non-inferiority trial

Autor: Manuel Toledo, Kiyohito Terada, Ting Li, Melissa Brock, Felix Rosenow, Konrad J. Werhahn, Marc De Backer, Michel Baulac

Publikováno v: The Lancet. Neurology. 16(1)

Summary Background Further options for monotherapy are needed to treat newly diagnosed epilepsy in adults. We assessed the efficacy, safety, and tolerability of lacosamide as a first-line monotherapy option for these patients. Methods In this phase 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8759bc8792bf2ecd0435edc44794f0f9
https://pubmed.ncbi.nlm.nih.gov/28102143

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