Výsledky vyhledávání - "Marc Da Costa"

Serum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS)

Autor: Marc Da Costa, Paul R. Heath, Janine Kirby, Esther Hobson, Rachel Waller, Jonathan Cooper-Knock, Pamela J. Shaw, Emily F. Goodall, Helen Wollff, Marta Milo, Mbombe Kazoka

Publikováno v: Neurobiology of Aging

Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative condition characterized by loss of motor neurones and progressive muscle wasting. There is no diagnostic test for ALS therefore robust biomarkers would not only be valuable for diagnos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8182e0186c5372d5b912d78ac97852bc
https://eprints.whiterose.ac.uk/114313/16/1-s2.0-S0197458017301033-main.pdf

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Deep learning for automatic cell detection in wide-field microscopy zebrafish images

Autor: Marc Da Costa, Ling Shao, Oliver Bandmann, Bo Dong, Alejandro F. Frangi

Publikováno v: ISBI

The zebrafish has become a popular experimental model organism for biomedical research. In this paper, a unique framework is proposed for automatically detecting Tyrosine Hydroxylase-containing (TH-labeled) cells in larval zebrafish brain z-stack ima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3a86ad4559f745a480903e6ebac7522
https://doi.org/10.1109/isbi.2015.7163986

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Three-Dimensional Deconvolution of Wide Field Microscopy with Sparse Priors: Application to Zebrafish Imagery

Autor: Bo Dong, Alejandro F. Frangi, Marc Da Costa, Ling Shao, Oliver Bandmann

Publikováno v: ICPR

Zebra fish, as a popular experimental model organism, has been frequently used in biomedical research. For observing, analysing and recording labelled transparent features in zebra fish images, it is often efficient and convenient to adopt the fluore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b941433d76d15910cd5bbdf2a636429c
https://doi.org/10.1109/icpr.2014.159

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Zebrafish-based small molecule screens for novel cardiovascular drugs

Autor: Timothy J. A. Chico, Peter Novodvorsky, Marc Da Costa

Publikováno v: Drug discovery today. Technologies. 10(1)

The zebrafish is increasingly being adopted as an in vivo model of high throughput drug screening. In this brief review we outline the advantages and disadvantages of this approach and summarize recent screens that have attempted to identify novel sm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aafc93355bd601263ce4f3732402479
https://pubmed.ncbi.nlm.nih.gov/24050238

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A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screening

Autor: Pamela J. Shaw, Tennore Ramesh, Marc Da Costa, Christopher J McDermott, Adrian Higginbottom, Claire E. Allen

Publikováno v: Disease Models & Mechanisms, Vol 7, Iss 1, Pp 73-81 (2014)
Disease Models & Mechanisms

Summary Mutations in the superoxide dismutase gene (SOD1) are one cause of familial amyotrophic lateral sclerosis [ALS; also known as motor neuron disase (MND)] in humans. ALS is a relentlessly progressive neurodegenerative disease and, to date, ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a6d5edd9691ebc50455750c07e6083
https://doi.org/10.1242/dmm.012013

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O NÃO-BRANCO, O SERTÃO E O PENSAMENTO SOCIAL BRASILEIRO

Autor: René Marc da Costa Silva

Publikováno v: Prismas: Direito, Políticas Públicas e Mundialização. 3

O presente artigo pretende compreender o processo pelo qual a invisibilidade social das pessoas negras foi construida atraves da categoria analitica e politica de “Sertao”. Esta abordagem sera desenvolvida com relacao ao pensamento social brasile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6460a7a3568c569e7772d5300441ce0d
https://doi.org/10.5102/prismas.v3i2.260

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MPP+ IN A ZEBRAFISH MODEL OF GLUCOCEREBROSIDASE 1 DEFICIENCY

Autor: Thomas Payne, Marc Da Costa, Marcus Keatinge, Oliver Bandmann

Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 86:e4.93-e4

ObjectiveTo determine if glucocerebrosidase 1 deficiency is a susceptibility factor to 1-methyl-4-phenylpyridinium (MPP+) toxicity using a zebrafish model.Background and hypothesisHeterozygous mutations in the glucocerebrosidase gene (GBA1) are a str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3f7f9a40b35eb4b96ef485951ee0ac1
https://doi.org/10.1136/jnnp-2015-312379.182

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