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of 5
pro vyhledávání: '"Marc D Singleton"'
Evolutionary analyses of intrinsically disordered regions reveal widespread signals of conservation.
Autor:
Marc D Singleton, Michael B Eisen
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 4, p e1012028 (2024)
Intrinsically disordered regions (IDRs) are segments of proteins without stable three-dimensional structures. As this flexibility allows them to interact with diverse binding partners, IDRs play key roles in cell signaling and gene expression. Despit
Externí odkaz:
https://doaj.org/article/cf4358f225ed4b4c822c756a348bcd82
Autor:
Catherine A. Wakeman, Jessica L. Moore, Michael J. Noto, Yaofang Zhang, Marc D. Singleton, Boone M. Prentice, Benjamin A. Gilston, Ryan S. Doster, Jennifer A. Gaddy, Walter J. Chazin, Richard M. Caprioli, Eric P. Skaar
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Co-infections with Pseudomonas aeruginosa and Staphylococcus aureus are common in cystic fibrosis patients. Here, the authors show that metal depletion induced by a host protein, calprotectin, promotes co-existence of both pathogens by inhibiting pro
Externí odkaz:
https://doaj.org/article/d51f678c97f6455c944b4d671341e53f
Autor:
Juan J. Marugan, Samarjit Patnaik, Udo Rudloff, Noel Southall, Debra Gilbert, Sui Huang, Chen Wang, Zachary Knotts, Christopher R. Dextras, Amy Wang, Stephanie Springer, Serguei Kozlov, Catherine Drennan, Marc Ferrer, Tomas Vilimas, Theresa Guerin, Kevin J. Frankowski, Jerome J. Schlomer, Emma Hughes, Marc D. Singleton, Xin Xu, Dandan Li
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Metarrestin is a first-in-class small molecule clinical candidate capable of disrupting the perinucleolar compartment, a subnuclear structure unique to metastatic cancer cells. This study aims to define the pharmacokinetic (PK) profile of met
Autor:
Richard M. Caprioli, Jennifer A. Gaddy, Michael J. Noto, Walter J. Chazin, Marc D. Singleton, Eric P. Skaar, Catherine A. Wakeman, Jessica L. Moore, Boone M. Prentice, Yaofang Zhang, Benjamin A. Gilston, Ryan S. Doster
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications
Nature Communications
Microorganisms form biofilms containing differentiated cell populations. To determine factors driving differentiation, we herein visualize protein and metal distributions within Pseudomonas aeruginosa biofilms using imaging mass spectrometry. These i
Autor:
Sharie J. Haugabook, Xin Xu, Susan Perrine-Faller, Kylie M. Konrath, Amy Wang, Emma Hughes, Marc D. Singleton
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S38