Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy

Autor: Maksymilian Prondzynski, Marc D Lemoine, Antonia TL Zech, András Horváth, Vittoria Di Mauro, Jussi T Koivumäki, Nico Kresin, Josefine Busch, Tobias Krause, Elisabeth Krämer, Saskia Schlossarek, Michael Spohn, Felix W Friedrich, Julia Münch, Sandra D Laufer, Charles Redwood, Alexander E Volk, Arne Hansen, Giulia Mearini, Daniele Catalucci, Christian Meyer, Torsten Christ, Monica Patten, Thomas Eschenhagen, Lucie Carrier

Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 8, Pp n/a-n/a (2022)

Externí odkaz: https://doaj.org/article/20088ae3e8874325a43b88d720c8d7fd

Ablation of Outflow Tract Arrhythmias in Patients With and Without Structural Heart Disease—A Comparative Analysis

Autor: Ruben Schleberger, Jan Riess, Anika Brauer, Hans O. Pinnschmidt, Laura Rottner, Fabian Moser, Julia Moser, Shinwan Kany, Ilaria My, Marc D. Lemoine, Bruno Reissmann, Christian Meyer, Andreas Metzner, Feifan Ouyang, Paulus Kirchhof, Andreas Rillig

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

IntroductionCatheter ablation of ventricular arrhythmias emerging from the ventricular outflow tracts and adjacent structures is very effective and considered almost curative in patients without structural heart disease (SHD). Outcomes of patients wi

Externí odkaz: https://doaj.org/article/1ef6a173221d41588328d3f1dd6a5004

ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes

Autor: Antonia T. L. Zech, Maksymilian Prondzynski, Sonia R. Singh, Niels Pietsch, Ellen Orthey, Erda Alizoti, Josefine Busch, Alexandra Madsen, Charlotta S. Behrens, Moritz Meyer-Jens, Giulia Mearini, Marc D. Lemoine, Elisabeth Krämer, Diogo Mosqueira, Sanamjeet Virdi, Daniela Indenbirken, Maren Depke, Manuela Gesell Salazar, Uwe Völker, Ingke Braren, William T. Pu, Thomas Eschenhagen, Elke Hammer, Saskia Schlossarek, Lucie Carrier

Publikováno v: Cells, Vol 11, Iss 17, p 2745 (2022)

Genetic variants in α-actinin-2 (ACTN2) are associated with several forms of (cardio)myopathy. We previously reported a heterozygous missense (c.740C>T) ACTN2 gene variant, associated with hypertrophic cardiomyopathy, and characterized by an electro

Externí odkaz: https://doaj.org/article/109fa3ab16674cf981367758f4aa3eb1

Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium

Autor: Marta Lemme, Bärbel M. Ulmer, Marc D. Lemoine, Antonia T.L. Zech, Frederik Flenner, Ursula Ravens, Hermann Reichenspurner, Miriam Rol-Garcia, Godfrey Smith, Arne Hansen, Torsten Christ, Thomas Eschenhagen

Publikováno v: Stem Cell Reports, Vol 11, Iss 6, Pp 1378-1390 (2018)

Summary: Cardiomyocytes (CMs) generated from human induced pluripotent stem cells (hiPSCs) are under investigation for their suitability as human models in preclinical drug development. Antiarrhythmic drug development focuses on atrial biology for th

Externí odkaz: https://doaj.org/article/9f074c489c1846e2b1fc42f04021209e

Repolarization indicates electrical instability in ventricular arrhythmia originating from papillary muscle

Autor: Paula Münkler, Niklas Klatt, Katharina Scherschel, Pawel Kuklik, Christiane Jungen, Ersin Cavus, Christian Eickholt, Jan Christoph, Marc D Lemoine, Torsten Christ, Stephan Willems, René Riedel, Paulus Kirchhof, Christian Meyer

Publikováno v: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, vol 25, iss 2

Aims Cardiac arrhythmia originating from the papillary muscle (PM) can trigger ventricular fibrillation (VF) and cause sudden cardiac death even in the absence of structural heart disease. Most premature ventricular contractions, however, are benign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bbfef1b8be56a231147594476234a9
https://doi.org/10.1093/europace/euac126