Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Marc D'Anjou"'
Autor:
Dustin Whitney, Ilya Shestopalov, Maeva Fincker, Marc d’Anjou, Kelly Kral, Marisa Gayron, Francis J. Pierciey, Richard A. Colvin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101155- (2023)
Ex vivo autologous hematopoietic stem cell lentiviral-based gene therapy with betibeglogene autotemcel has been studied in patients with transfusion-dependent β-thalassemia in Phase III clinical trials (HGB-207 and HGB-212), with 90% of patients rea
Externí odkaz:
https://doaj.org/article/66defa76c700452da555b487cb91435f
Autor:
Dustin Whitney, Ilya Shestopalov, Marc D’Anjou, Maeva Fincker, Ge Tao, Kelly Kral, Richard A. Colvin
Publikováno v:
Transplantation and Cellular Therapy. 28:S27
Autor:
Gary W. Small, Adam Nylen, Muralidhar R. Mallem, Marc d′Anjou, Jonathon T. Olesberg, Ishaan Shandil, Elizabeth R. Gibson, Mark A. Arnold, Kaylee J. Lanz, Edwin J. Koerperick, Gregory Allan Brower, Christine Esther Evans, Daniel W. Cooley, Sehoon Kim
Publikováno v:
Biochemical Engineering Journal. 94:115-124
Monoclonal antibody production in glycoengineered Pichia pastoris was optimized for high cell density fed-batch fermentations. Results show that antibody productivity was 1.72-fold higher when maintaining oxygen-limited conditions compared to methano
Autor:
Byung-Kwon, Choi, Shannon, Warburton, Heping, Lin, Rohan, Patel, Istvan, Boldogh, Michael, Meehl, Meehl, Meehl, Marc, d'Anjou, Liza, Pon, Terrance A, Stadheim, Natarajan, Sethuraman
Publikováno v:
Applied Microbiology and Biotechnology. 95:671-682
Yeast is capable of performing posttranslational modifications, such as N- or O-glycosylation. It has been demonstrated that N-glycans play critical biological roles in therapeutic glycoproteins by modulating pharmacokinetics and pharmacodynamics. Ho
Autor:
Sujatha Gomathinayagam, Nathan Sharkey, Peter M. Gray, Adam Nylen, Min Du, Thomas I. Potgieter, Seemab S. Shaikh, Raymond Evers, Terrance A. Stadheim, Robert C. Davidson, Russell B. Lingham, Julie A. DeMartino, Gavin C. Barnard, Daniel Hopkins, Muralidhar R. Mallem, Natarajan Sethuraman, Juergen H. Nett, Victoria Copeland, Thomas O. Linden, Marc d’Anjou, Yan Li, Liming Liu, Teresa Mitchell, Stephen R. Hamilton, Bing Gong, Denise M. Visco, Gail Forrest, Huijuan Li, Stefan Wildt
Publikováno v:
Journal of Biotechnology. 157:198-206
Pichia pastoris is a methylotropic yeast that has gained great importance as an organism for protein expression in recent years. Here, we report the expression of recombinant human erythropoietin (rhEPO) in glycoengineered P. pastoris. We show that g
Autor:
Marc d’Anjou, Andre Walker, Marina Berdichevsky, Bianka Prinz, Amy Hsu, Kathleen McLaughlin, D. Sean Kersey, Kathryn Watts, David Pollard, Jianxin Ye, Thomas I. Potgieter, Jeffrey Ly
Publikováno v:
Biotechnology Progress. 27:1744-1750
Glycoengineering enabled the production of proteins with human N-linked glycans by Pichia pastoris. This study used a glycoengineered P. pastoris strain which is capable of producing humanized glycoprotein with terminal galactose for monoclonal antib
Publikováno v:
Biotechnology and Bioengineering. 106:918-927
Growth of the antibody market has fueled the development of alternative expression systems such as glycoengineered yeast. Although intact antibody expression levels in excess of 1 g L(-1) have been demonstrated in glycoengineered yeast, this is still
Autor:
Huijuan Li, Marc d’Anjou
Publikováno v:
Current Opinion in Biotechnology. 20:678-684
Glycoproteins represent the major share of marketed and clinical development phase therapeutic proteins. A thorough understanding of the nature and function of the carbohydrate moiety and its impact on pharmacology properties is essential in discover
Autor:
Youwei Jiang, Nga Rewa Houston-Cummings, Marc d’Anjou, Troy McKelvey, Adam Nylen, Michael Cukan, Alissa M. Rittenhour, Fang Li, Teresa Mitchell, Thomas I. Potgieter, Muralidhar R. Mallem, Heather Lynaugh, Terrance A. Stadheim, Dongxing Zha, James E. Drummond
Publikováno v:
Journal of Biotechnology. 139:318-325
The growing antibody market and the pressure to improve productivity as well as reduce cost of production have fueled the development of alternative expression systems. The therapeutic function of many antibodies is influenced by N-linked glycosylati
Autor:
Marc d’Anjou, Sandra Rios, Paul Gollnick, Huijuan Li, Jeffrey K. Actor, Shannon Warburton, Jolanta Artym, Marian L. Kruzel, Byung-Kwon Choi, Stefan Wildt, Michał Zimecki, Michael Cukan, Angela Kull, Maja Kocięba, Terrance A. Stadheim, Erin Giaccone, Nathan Sharkey
Publikováno v:
Glycoconjugate Journal. 25:581-593
Traditional production of therapeutic glycoproteins relies on mammalian cell culture technology. Glycoproteins produced by mammalian cells invariably display N-glycan heterogeneity resulting in a mixture of glycoforms the composition of which varies