Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marc Ceusters"'
Autor:
Omar Mamad, Mona Heiland, Andreas U. Lindner, Thomas D. M. Hill, Ronan M. Ronroy, Kilian Rentrup, Amaya Sanz-Rodriguez, Elena Langa, Janosch P. Heller, Oscar Moreno, Jordi Llop, Anindya Bhattacharya, James A. Palmer, Marc Ceusters, Tobias Engel, David C. Henshall
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
There remains a need for new drug targets for treatment-resistant temporal lobe epilepsy. The ATP-gated P2X7 receptor coordinates neuroinflammatory responses to tissue injury. Previous studies in mice reported that the P2X7 receptor antagonist JNJ-47
Externí odkaz:
https://doaj.org/article/4fa05e1ff28e4d35a32f692bc0e2ed81
Autor:
Kasper Recourt, Peter de Boer, Peter van der Ark, Heike Benes, Joop M. A. van Gerven, Marc Ceusters, Luc van Nueten, Wayne C. Drevets, Anindya Bhatacharya, Michael Browning, Gabriel E. Jacobs
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral interleukin (IL)-1β release, and attenuated dexamphetamine-induce
Externí odkaz:
https://doaj.org/article/ce0f225410c64ac8b7a1ca0270900c52
Autor:
Gallen Triana-Baltzer, Maarten Timmers, Peter De Boer, Manja Schoene, Maura Furey, Cathy Bleys, Isabeau Vrancken, Randy Slemmon, Marc Ceusters, Luc van Nueten, Hartmuth Kolb
Publikováno v:
Comprehensive Psychoneuroendocrinology, Vol 10, Iss , Pp 100116- (2022)
Identification of putative biomarkers for neuropsychiatric disorders has produced a diverse list of analytes involved in inflammation, hypothalamic–pituitary–adrenal axis (HPA) regulation, growth factor and metabolic pathways. However, translatio
Externí odkaz:
https://doaj.org/article/f4be229663064b649cc97b1d83654ab8
Autor:
Cristina Ruiz-Ruiz, Nuria García-Magro, Pilar Negredo, Carlos Avendaño, Anindya Bhattacharya, Marc Ceusters, Antonio G. García
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 10 (2020)
Neuroinflammation is one of the main physiopathological mechanisms of amyotrophic lateral sclerosis (ALS), produced by the chronic activation of microglia in the CNS. This process is triggered by the persistent activation of the ATP-gated P2X7 recept
Externí odkaz:
https://doaj.org/article/366e327938e1491791efa02fb94b21d1
Autor:
James Morgan, Oscar Moreno, Mariana Alves, Zuriñe Baz, Aida Menéndez Méndez, Hanna Leister, Ciara Melia, Jonathon Smith, Alexander Visekruna, Annette Nicke, Anindya Bhattacharya, Marc Ceusters, David C. Henshall, Vanessa Gómez‐Vallejo, Jordi Llop, Tobias Engel
Publikováno v:
Epilepsia. 64:511-523
Autor:
Jonathon Smith, Aida Menéndez Méndez, Mariana Alves, Alberto Parras, Giorgia Conte, Anindya Bhattacharya, Marc Ceusters, Annette Nicke, David C. Henshall, Eva M. Jimenez‐Mateos, Tobias Engel
Publikováno v:
British Journal of Pharmacology.
Autor:
James, Morgan, Oscar, Moreno, Mariana, Alves, Zuriñe, Baz, Aida, Menéndez Méndez, Hanna, Leister, Ciara, Melia, Jonathon, Smith, Alexander, Visekruna, Annette, Nicke, Anindya, Bhattacharya, Marc, Ceusters, David C, Henshall, Vanessa, Gómez-Vallejo, Jordi, Llop, Tobias, Engel
Publikováno v:
Epilepsia.
The P2X7 receptor (P2X7R) is an important contributor to neuroinflammation, responding to extracellularly released ATP. Expression of the P2X7R is increased in the brain in experimental and human epilepsy and genetic or pharmacologic targeting of the
Autor:
Jonathon Smith, Aida Menendez Mendez, Mariana Alves, Alberto Parras, Giorgia Conte, Anindya Bhattacharya, Marc Ceusters, Annette Nicke, David Henshall, Eva Jimenez-Mateos, Tobias Engel
Background and Purpose Neonatal seizures are a clinical emergency. Current anti-seizure medications, however, fail to resolve seizures in ~50% of infants. The P2X7 receptor (P2X7R) is an important driver of inflammation and evidence suggest P2X7R con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a236409a011733c4968e8e2862afb255
https://doi.org/10.22541/au.166508305.54244816/v1
https://doi.org/10.22541/au.166508305.54244816/v1
Autor:
Marc Ceusters, Jodi L. Lukkes, Luc ver Donck, William A. Truitt, Justine M. Kent, Erik T. Dustrude, Andrei I. Molosh, Seema Bhatnagar, Pascal Bonaventure, Philip L. Johnson, Anantha Shekhar
Publikováno v:
Biological Psychiatry. 85:S30-S31
Autor:
Terrence Deak, Michael A. Letavic, Anindya Bhattacharya, Marc Ceusters, Elena I. Varlinskaya, Robert Neff, Pascal Bonaventure, Timothy W. Lovenberg, Nicholas I. Carruthers, Wilhelmus Drinkenburg, James R. Shoblock, Brian Lord, Leah Aluisio
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:628-641
In the central nervous system, the ATP-gated Purinergic receptor P2X ligand-gated ion channel 7 (P2X7) is expressed in glial cells and modulates neurophysiology via release of gliotransmitters, including the proinflammatory cytokine interleukin (IL)-