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Akademický článek

Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab

Autor: Mercè Farràs, Ramón Román, Marc Camps, Joan Miret, Óscar Martínez, Xavier Pujol, Antoni Casablancas, Jordi Joan Cairó

Publikováno v: BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-9 (2020)

Abstract Background Monoclonal antibodies (mAbs) and their derivatives have become one of the most important classes of therapeutic drugs. Their multiple applications increased the interest for understanding their complex structure. In vivo, animal c

Externí odkaz: https://doaj.org/article/d1a4b7b88e00425ababbe69eb9cb8987

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Akademický článek

Homogeneous antibody-drug conjugates: DAR 2 anti-HER2 obtained by conjugation on isolated light chain followed by mAb assembly

Autor: Mercè Farràs, Joan Miret, Marc Camps, Ramón Román, Óscar Martínez, Xavier Pujol, Stéphane Erb, Anthony Ehkirch, Sarah Cianferani, Antoni Casablancas, Jordi Joan Cairó

Publikováno v: mAbs, Vol 12, Iss 1 (2020)

Despite advances in medical care, cancer remains a major threat to human health. Antibody-drug conjugates (ADCs) are a promising targeted therapy to overcome adverse side effects to normal tissues. In this field, the current challenge is obtaining ho

Externí odkaz: https://doaj.org/article/fed4e5c32d0c4f24a14729d42cf85902

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Insight on the Impact of the Reduction Step on the Site‐Directed Conjugation of an Anti‐HER2 Cysteine‐Engineered Antibody

Autor: Ramón Román, Jordi J. Cairó, Sarah Cianférani, Antoni Casablancas, Mercè Farràs, Joan Miret, Marc Camps, Stéphane Erb

Publikováno v: ChemistrySelect
ChemistrySelect, Wiley, 2020, 5 (11), pp.3187-3190. ⟨10.1002/slct.201903913⟩

International audience; Cysteine‐based conjugation is one of the main antibody conjugation strategies for generating both heterogeneous and homogeneous Antibody Drug Conjugates (ADCs), being the reduction of the antibody a crucial step in these pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74bd39fb429d39b4e4667b57acfeb77b
https://hal.archives-ouvertes.fr/hal-02892397

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Homogeneous antibody-drug conjugates: DAR 2 anti-HER2 obtained by conjugation on isolated light chain followed by mAb assembly

Autor: Anthony Ehkirch, Ramón Román, Joan Miret, Antoni Casablancas, Sarah Cianférani, Marc Camps, Stéphane Erb, Mercè Farràs, Jordi J. Cairó, Óscar Martínez, Xavier Pujol

Publikováno v: mAbs
mAbs, Taylor & Francis, 2020, 12 (1), pp.1702262. ⟨10.1080/19420862.2019.1702262⟩
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

International audience; Despite advances in medical care, cancer remains a major threat to human health. Antibody-drug conjugates (ADCs) are a promising targeted therapy to overcome adverse side effects to normal tissues. In this field, the current c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512b15060963ddb225beeb96aed1745f
https://hal.archives-ouvertes.fr/hal-03073004/document

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Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab

Autor: Antoni Casablancas, Jordi J. Cairó, Óscar Martínez, Ramón Román, Marc Camps, Xavier Pujol, Mercè Farràs, Joan Miret

Publikováno v: BMC Molecular and Cell Biology
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-9 (2020)
Recercat. Dipósit de la Recerca de Catalunya
instname
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)

Background Monoclonal antibodies (mAbs) and their derivatives have become one of the most important classes of therapeutic drugs. Their multiple applications increased the interest for understanding their complex structure. In vivo, animal cells are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2041a5a3cdb4186567a9ca031bc0b36e
https://pubmed.ncbi.nlm.nih.gov/31964343

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