Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Marc Campitelli"'
Publikováno v:
Marine Drugs, Vol 12, Iss 3, Pp 1169-1184 (2014)
Marine trypanocidal natural products are, most often, reported with trypanocidal activity and selectivity against human cell lines. The triaging of hits requires a consideration of chemical tractability for drug development. We utilized a combined Li
Externí odkaz:
https://doaj.org/article/084b771a911d44a2b6f2000d435c7b84
Autor:
Mauro Pascolutti, Marc Campitelli, Bao Nguyen, Ngoc Pham, Alain-Dominique Gorse, Ronald J Quinn
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0120942 (2015)
Natural products are universally recognized to contribute valuable chemical diversity to the design of molecular screening libraries. The analysis undertaken in this work, provides a foundation for the generation of fragment screening libraries that
Externí odkaz:
https://doaj.org/article/ee94ab1f39c347e09340cb6b9cd09e8a
Publikováno v:
Journal of Natural Products. 78:1370-1382
The impact of time, therapy area, and route of administration on 13 physicochemical properties calculated for 664 drugs developed from a natural prototype was investigated. The mean values for the majority of properties sampled over five periods from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c440be17006421e5ecb051982b1a79e
https://doi.org/10.1021/acs.jnatprod.5b00255
https://doi.org/10.1021/acs.jnatprod.5b00255