Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Marc C. Ippolito"'
Autor:
Soumya P. Sahoo, Samuel D. Wright, David E. Moller, Julia K. Boueres, Karen L. MacNaul, Marc C. Ippolito, Joel P. Berger, Arun K. Agrawal, Daniel J. Miller, Pei-Ran Wang, Hiroo Koyama
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3347-3351
A SAR study was conducted on chromane-2-carboxylic acid toward selective PPARα agonisim. As a result, highly potent, and selective PPARα agonists were discovered. The optimized compound 43 exhibited robust lowering of total cholesterol levels in ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db3e18a696be690baf72057ee41674b
https://doi.org/10.1016/j.bmcl.2005.05.028
https://doi.org/10.1016/j.bmcl.2005.05.028
Autor:
Arun K. Agrawal, Thomas W. Doebber, Pei-Ran Wang, Daniel J. Miller, James V. Heck, Julia K. Boueres, Marc C. Ippolito, Soumya P. Sahoo, Linda J. Kelly, Samuel D. Wright, Yu-Sheng Chao, Hiroo Koyama, A. Brian Jones, Gaochao Zhou, Joel P. Berger, David E. Moller, Ronald B. Franklin, Karen L. MacNaul, Ranjit C. Desai, Margaret Wu
Publikováno v:
Journal of Medicinal Chemistry. 47:3255-3263
A series of chromane-2-carboxylic acid derivatives was synthesized and evaluated for PPAR agonist activities. A structure-activity relationship was developed toward PPARalpha/gamma dual agonism. As a result, (2R)-7-(3-[2-chloro-4-(4-fluorophenoxy)phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f8f7be20ef0493afda0cab77841421
https://doi.org/10.1021/jm030621d
https://doi.org/10.1021/jm030621d
Autor:
Joel P. Berger, Melba Hernandez, Wei Han, Carl P. Sparrow, Chhabi Biswas, Joanne Baffic, James V. Heck, Pei-Ran Wang, Samuel D. Wright, Gaochao Zhou, Yu-Sheng Chao, Qiu Guo, David E. Moller, Karen L. MacNaul, Denise P. Milot, Ranjit C. Desai, Neelam Sharma, Soumya P. Sahoo, Marc C. Ippolito, My-Hanh Lam, Linda J. Kelly, Margaret Wu, Thomas W. Doebber
Publikováno v:
Endocrinology. 145:1640-1648
Patients with type 2 diabetes mellitus exhibit hyperglycemia and dyslipidemia as well as a markedly increased incidence of atherosclerotic cardiovascular disease. Here we report the characterization of a novel arylthiazolidinedione capable of lowerin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175dcc68b6952d7d3f93601399fd22f8
https://doi.org/10.1210/en.2003-1270
https://doi.org/10.1210/en.2003-1270
Autor:
Margaret Wu, Linda J. Kelly, Thomas W. Doebber, Joel P. Berger, Ying Li, Pei-Ran Wang, Yu-Sheng Chao, Chhabi Biswas, Roger Meurer, David E. Moller, Gaochao Zhou, Marc C. Ippolito, Samuel D. Wright
Publikováno v:
Biochemical and biophysical research communications. 318(2)
Here, we characterize the actions of MK-0767, a dual ligand of the nuclear receptors peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma. In cell-based assays, MK-0767 produced potent activation of human PPARgamma and PPARalpha with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee76ec094c25c2a5575062b98bb11f6
https://pubmed.ncbi.nlm.nih.gov/15120604
https://pubmed.ncbi.nlm.nih.gov/15120604
Autor:
Denise P. Milot, Melba Hernandez, Pei-Ran Wang, Charlotte Burton, Marc C. Ippolito, Samuel D. Wright, Qiu Guo, Yu-Sheng Chao
Publikováno v:
Biochimica et biophysica acta. 1533(3)
Fenofibrate is a potent hypolipidemic agent that lowers plasma lipid levels and may thus decrease the incidence of atherosclerosis. Here we investigated the molecular mechanism of fenofibrate’s hypolipidemic action by characterizing its in vivo eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c896363217b9e59446f0b370c21e51b0
https://pubmed.ncbi.nlm.nih.gov/11731332
https://pubmed.ncbi.nlm.nih.gov/11731332
Autor:
John Ventre, Tom Doebber, Denise P. Milot, Samuel D. Wright, Pei-Ran Wang, Margaret Wu, Qiu Guo, Yu-Sheng Chao, Marc C. Ippolito
Publikováno v:
European journal of pharmacology. 427(3)
Dyslipidemia, a major risk factor for cardiovascular disease, may be directly linked to diabetic hyperglycemia and insulin resistance. An appropriate dyslipidemic animal model that has diabetes would provide an important tool for research on the trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b2f0a13e855ca26ff3abe52f144f74
https://pubmed.ncbi.nlm.nih.gov/11567659
https://pubmed.ncbi.nlm.nih.gov/11567659
Autor:
David Gerhold, Steven S. Mundt, Rolf Thieringer, Linda J. Kelly, Pei-Ran Wang, Meiqing Lu, Margaret Wu, Vilert A. Loving, Denise P. Milot, Alex Elbrecht, Anne Hermanowski-Vosatka, Yu-Sheng Chao, Marc C. Ippolito, Yuli Chen, Samuel D. Wright, Qiu Guo, Thomas W. Doebber
Publikováno v:
Biochemical and biophysical research communications. 279(2)
11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) is an enzyme that converts cortisone to the active glucocorticoid, cortisol. Cortisol-cortisone interconversion plays a key role in the regulation of glucose metabolism, since mice deficient in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d35b9deb5e8543081fbded20a5d50e
https://pubmed.ncbi.nlm.nih.gov/11118287
https://pubmed.ncbi.nlm.nih.gov/11118287