Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Marc C. Deller"'
Autor:
Adriana Irimia, Andreia M Serra, Anita Sarkar, Ronald Jacak, Oleksandr Kalyuzhniy, Devin Sok, Karen L Saye-Francisco, Torben Schiffner, Ryan Tingle, Michael Kubitz, Yumiko Adachi, Robyn L Stanfield, Marc C Deller, Dennis R Burton, William R Schief, Ian A Wilson
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006212 (2017)
Among broadly neutralizing antibodies to HIV, 10E8 exhibits greater neutralizing breadth than most. Consequently, this antibody is the focus of prophylactic/therapeutic development. The 10E8 epitope has been identified as the conserved membrane proxi
Externí odkaz:
https://doaj.org/article/f681c9af5ada49bfa2774b8fa38434ae
Autor:
Marc C Deller, Hope A Johnson, Mitchell D Miller, Glen Spraggon, Marc-André Elsliger, Ian A Wilson, Scott A Lesley
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122512 (2015)
The TM1088 locus of T. maritima codes for two proteins designated TM1088A and TM1088B, which combine to form the cytosolic portion of a putative Trk K+ transporter. We report the crystal structure of this assembly to a resolution of 3.45 Å. The high
Externí odkaz:
https://doaj.org/article/786a0a1d07d640b7a732a35ec3596383
Autor:
Qingping Xu, Marc C Deller, Tine K Nielsen, Joanna C Grant, Scott A Lesley, Marc-André Elsliger, Ashley M Deacon, Ian A Wilson
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107309 (2014)
Kanadaptin is a nuclear protein of unknown function that is widely expressed in mammalian tissues. The crystal structure of the forkhead-associated (FHA) domain of human kanadaptin was determined to 1.6 Å resolution. The structure reveals an asymmet
Externí odkaz:
https://doaj.org/article/927ce7732ffc4266a9e4e2067c26f1d5
Publikováno v:
ACS chemical biology, vol 12, iss 4
Polysaccharide monooxygenases (PMOs) are secreted metalloenzymes that catalyze the oxidative degradation of polysaccharides in a copper-, oxygen-, and reductant-dependent manner. Cellulose-active fungal PMOs degrade cellulosic substrates to be utiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79d931876f4f4d248a61042148ee2e8
https://doi.org/10.1021/acschembio.7b00016
https://doi.org/10.1021/acschembio.7b00016
Autor:
Yuxing Li, Xiaolin Ji, Richard T. Wyatt, Kunxue Hong, Andrew B. Ward, Krisha McKee, Sijy O'Dell, Jiandong Liu, Bin Ju, John R. Mascola, Yanli Chen, Yajing Chen, Yanling Hao, Fernando Garces, Yuanzi Hua, G. Ozorowski, Bin Su, Li Ren, Leopold Kong, Yiming Shao, Jiang Zhu, Linling He, Kaifan Dai, Yi Feng, Marc C. Deller, Zheng Wang, Ian A. Wilson, Richard K. Wilson
Publikováno v:
Immunity. 44:939-950
VRC01-class antibodies neutralize diverse HIV-1 strains by targeting the conserved CD4-binding site. Despite extensive investigations, crucial events in the early stage of VRC01 development remain elusive. We demonstrated how VRC01-class antibodies e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4734b6160fc2cb542cfd339605ce61d1
https://doi.org/10.1016/j.immuni.2016.03.006
https://doi.org/10.1016/j.immuni.2016.03.006
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
An understanding of protein stability is essential for optimizing the expression, purification and crystallization of proteins. In this review, discussion will focus on factors affecting protein stability on a somewhat practical level, particularly f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192036df0453e6a2194c9138b4133b91
https://doi.org/10.1107/s2053230x15024619
https://doi.org/10.1107/s2053230x15024619
Autor:
Natalia Sevillano, Marc C. Deller, David E. Cane, Yu-Chen Liu, Florencia La Greca, Charles S. Craik, Lindsay Deis, Tsutomu Matsui, Irimpan I. Mathews, Chaitan Khosla, Xiuyuan Li
Catalytic modules of assembly-line polyketide synthases (PKSs) have previously been observed in two very different conformations—an “extended” architecture and an “arch-shaped” architecture—although the catalytic relevance of neither has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0d35c9c7114523b0fa6939d6973a77
https://europepmc.org/articles/PMC6484869/
https://europepmc.org/articles/PMC6484869/
Autor:
Bernhard Rupp, Marc C. Deller
Publikováno v:
Journal of Computer-Aided Molecular Design. 29:817-836
X-ray crystallography provides the most accurate models of protein–ligand structures. These models serve as the foundation of many computational methods including structure prediction, molecular modelling, and structure-based drug design. The succe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694084bd7e04ef46bbf0cdef7de1e849
https://doi.org/10.1007/s10822-015-9833-8
https://doi.org/10.1007/s10822-015-9833-8
Autor:
Marc C. Deller, Kwinten Sliepen, Fernando Garces, Alba Torrents de la Peña, Leopold Kong, Rogier W. Sanders, Robyn L. Stanfield, Yuanzi Hua, Ian A. Wilson
Publikováno v:
Acta crystallographica. Section D, Biological crystallography, 71(Part 10), 2099-2108. International Union of Crystallography
The HIV-1 envelope gp160 glycoprotein (Env) is a trimer of gp120 and gp41 heterodimers that mediates cell entry and is the primary target of the humoral immune response. Broadly neutralizing antibodies (bNAbs) to HIV-1 have revealed multiple epitopes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35484957c1ac5d6c20017fff783b6f8
https://doi.org/10.1107/s1399004715013917
https://doi.org/10.1107/s1399004715013917
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1607
Models of target proteins in complex with small molecule ligands or peptide ligands are of significant interest to the biomedical research community. Structure-guided lead discovery and structure-based drug design make extensive use of such models. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbe7066e31b7cdd90a9b516791f4083f
https://pubmed.ncbi.nlm.nih.gov/28573591
https://pubmed.ncbi.nlm.nih.gov/28573591