Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marc C. Daniels"'
Autor:
Leon F. Hebert, Jiping Tang, Donald A. McClain, Robert C. Cooksey, Marc C. Daniels, Errol D. Crook, Geddati Veerababu, Rosemary T. Hoffman
Publikováno v:
Diabetes. 49:2070-2078
To examine the effect of increased hexosamine flux in liver, the rate-limiting enzyme in hexosamine biosynthesis (glutamine:fructose-6-phosphate amidotransferase [GFA]) was overexpressed in transgenic mice using the PEPCK promoter. Liver from random-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ce4c6722aa95c78621e840a6543fcd
https://doi.org/10.2337/diabetes.49.12.2070
https://doi.org/10.2337/diabetes.49.12.2070
Publikováno v:
Journal of Biological Chemistry. 275:31847-31856
Transcription of the phosphoenolpyruvate carboxykinase (PEPCK) gene is regulated by a variety of agents. Glucocorticoids, retinoic acid, and glucagon (via its second messenger, cAMP) stimulate PEPCK gene transcription, whereas insulin, phorbol esters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0d97f45b2cdf6673e4875df476d2bb
https://doi.org/10.1074/jbc.m003656200
https://doi.org/10.1074/jbc.m003656200
Publikováno v:
The American Journal of the Medical Sciences. 319:138-142
Background: The hexosamine biosynthesis pathway (HBP) is hypothesized to mediate many of the adverse effects of hyperglycemia. We have shown previously that increased flux through this pathway leads to induction of the growth factor transforming grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b212e801cbedaa8e92615dcbde2017c0
https://doi.org/10.1016/s0002-9629(15)40711-6
https://doi.org/10.1016/s0002-9629(15)40711-6
Autor:
Hannele Yki-Järvinen, Marc C. Daniels, Antti Virkamäki, Donald A. McClain, W.Kirby Gottschalk
Publikováno v:
Metabolism. 47:449-455
O-linked N-acetylglucosamine (O-GlcNAc) is an abundant posttranslational modification of serine/threonine residues of nuclear and cytoplasmic proteins. We determined whether insulin or coinfusion of glucosamine (GlcN) with insulin alters O-GlcNAc of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48b628392499c4aa76d3bd3ad67f99d
https://doi.org/10.1016/s0026-0495(98)90058-0
https://doi.org/10.1016/s0026-0495(98)90058-0
Autor:
Marc C. Daniels, Antti Virkamäki, Hannele Yki-Järvinen, Sari Hämäläinen, Donald A. McClain, Tapio Utriainen
Publikováno v:
Endocrinology. 138:2501-2507
We determined the effect of infusion of glucosamine (GlcN), which bypasses the rate limiting reaction in the hexosamine pathway, on insulin-stimulated rates of glucose uptake and glycogen synthesis in vivo in rat tissues varying with respect to their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::337dda897dcbcbdf08e689481f63bbf6
https://doi.org/10.1210/endo.138.6.5172
https://doi.org/10.1210/endo.138.6.5172
Autor:
Lawrence J. Mandarino, Christoph Vogt, Patricia Iozzo, Sari Mäkimattila, H YkiJarvinen, Donald A. McClain, Antti Virkamäki, Ruben Pipek, William K. Gottschalk, Ralph A. DeFronzo, Marc C. Daniels
Publikováno v:
Diabetologia. 40:76-81
Glutamine:fructose 6-phosphate amidotransferase (GFA) is rate-limiting for hexosamine biosynthesis, while a UDP-GlcNAc beta-N-acetylglucosaminyltransferase (O-GlcNAc transferase) catalyses final O-linked attachment of GlcNAc to serine and threonine r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de96b6d02f3e9fcf5777b7b5bacfa876
https://doi.org/10.1007/s001250050645
https://doi.org/10.1007/s001250050645
Publikováno v:
Diabetes. 44:314-320
The hexosamine biosynthesis pathway has been hypothesized to mediate some of the regulatory as well as the deleterious effects of glucose. We have stably overexpressed the cDNA for human glutamine:fructose-6-phosphate amidotransferase (GFA), the rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b36c4c5f2b24f31a433edd9bcf1002
https://doi.org/10.2337/diab.44.3.314
https://doi.org/10.2337/diab.44.3.314
Autor:
J. Jason Collier, Jill R. Schurr, Donald K. Scott, Marc C. Daniels, Jay K. Kolls, Thuy-Trang T. Doan
Publikováno v:
The Journal of biological chemistry. 278(8)
Glucose exerts powerful effects on hepatocyte gene transcription by mechanisms that are incompletely understood. c-Myc regulates hepatic glucose metabolism by increasing glycolytic enzyme gene transcription while concomitantly decreasing gluconeogeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3682ad2552d7fddb92c6acebfd4c871
https://pubmed.ncbi.nlm.nih.gov/12480946
https://pubmed.ncbi.nlm.nih.gov/12480946
Publikováno v:
The American journal of the medical sciences. 319(3)
The hexosamine biosynthesis pathway (HBP) is hypothesized to mediate many of the adverse effects of hyperglycemia. We have shown previously that increased flux through this pathway leads to induction of the growth factor transforming growth factor-al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae4c0fddf484a6eb7978f6796d4f226
https://pubmed.ncbi.nlm.nih.gov/10746823
https://pubmed.ncbi.nlm.nih.gov/10746823
Autor:
E A Gulve, Jianxin Zhou, Q K Huynh, R T Hoffman, Donald A. McClain, Marc C. Daniels, Errol D. Crook
Publikováno v:
Diabetes. 47(12)
Glutamine:fructose-6-phosphate amidotransferase (GFA) is the rate-limiting enzyme in hexosamine biosynthesis, an important pathway for cellular glucose sensing. Human GFA has two potential sites for phosphorylation by cAMP-dependent protein kinase A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a873f318f6781391319308d0cc2c4307
https://pubmed.ncbi.nlm.nih.gov/9836513
https://pubmed.ncbi.nlm.nih.gov/9836513