Exploring the predictive potential of programmed death ligand 1 expression in healthy organs and lymph nodes as measured by 18F-BMS-986192 PET: pooled analysis of data from four solid tumor types

Autor: Tanja D de Gruijl, Rieneke van de Ven, Geke A P Hospers, Marc C Huisman, Gerben J C Zwezerijnen, C Willemien Menke-van der Houven van Oordt, Iris H C Miedema, Johanna E. E. Pouw, Anne Kwakman, Florentine E F Timmer, Adrianus J de Langen

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 6 (2024)

Introduction Immune checkpoint inhibitors (ICIs) can elicit anticancer immune responses, but predictive biomarkers are needed. We measured programmed death ligand 1 (PD-L1) expression in organs and lymph nodes using 18F-BMS-986192 positron emission t

Externí odkaz: https://doaj.org/article/25fc274b5a5a47a2b15beea98d6e7ced

Performance of 89Zr-Labeled-Rituximab-PET as an Imaging Biomarker to Assess CD20 Targeting: A Pilot Study in Patients with Relapsed/Refractory Diffuse Large B Cell Lymphoma.

Autor: Yvonne W S Jauw, Josée M Zijlstra, Daphne de Jong, Danielle J Vugts, Sonja Zweegman, Otto S Hoekstra, Guus A M S van Dongen, Marc C Huisman

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0169828 (2017)

Treatment of patients with diffuse large B cell lymphoma (DLBCL) includes rituximab, an anti-CD20 monoclonal antibody (mAb). Insufficient tumor targeting might cause therapy failure. Tumor uptake of 89Zirconium (89Zr)-mAb is a potential imaging bioma

Externí odkaz: https://doaj.org/article/aa08a95257eb45329d6e3009ae7b3c4c

Noise sensitivity of 89Zr-Immuno-PET radiomics based on count-reduced clinical images

Autor: Ananthi Somasundaram, David Vállez García, Elisabeth Pfaehler, Yvonne W. S. Jauw, Josée M. Zijlstra, Guus A. M. S. van Dongen, Willemien C. Menke-van der Houven van Oordt, Marc C. Huisman, Elisabeth G. E. de Vries, Ronald Boellaard

Publikováno v: EJNMMI Physics, Vol 9, Iss 1, Pp 1-13 (2022)

Abstract Purpose Low photon count in 89Zr-Immuno-PET results in images with a low signal-to-noise ratio (SNR). Since PET radiomics are sensitive to noise, this study focuses on the impact of noise on radiomic features from 89Zr-Immuno-PET clinical im

Externí odkaz: https://doaj.org/article/e68e45dee393427aba60c8fc28f050d3

Performance of nanoScan PET/CT and PET/MR for quantitative imaging of 18F and 89Zr as compared with ex vivo biodistribution in tumor-bearing mice

Autor: Marion Chomet, Maxime Schreurs, Ricardo Vos, Mariska Verlaan, Esther J. Kooijman, Alex J. Poot, Ronald Boellaard, Albert D. Windhorst, Guus AMS van Dongen, Danielle J. Vugts, Marc C. Huisman, Wissam Beaino

Publikováno v: EJNMMI Research, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Introduction The assessment of ex vivo biodistribution is the preferred method for quantification of radiotracers biodistribution in preclinical models, but is not in line with current ethics on animal research. PET imaging allows for noninv

Externí odkaz: https://doaj.org/article/4f3ec609f1134052bbce1d4d7d199044

Characterizing the Bone Marrow Environment in Advanced-Stage Myelofibrosis during Ruxolitinib Treatment Using PET/CT and MRI

Autor: Stefanie Slot, Cristina Lavini, Gerben J. C. Zwezerijnen, Bouke J. H. Boden, J. Tim Marcus, Marc C. Huisman, Maqsood Yaqub, Ellis Barbé, Mariëlle J. Wondergem, Josée M. Zijlstra, Sonja Zweegman, Pieter G. Raijmakers

Publikováno v: Tomography (Ann Arbor, Mich.), 9(2), 459-474. Multidisciplinary Digital Publishing Institute (MDPI)
Tomography
Volume 9
Issue 2
Pages: 459-474
Slot, S, Lavini, C, Zwezerijnen, G J C, Boden, B J H, Marcus, J T, Huisman, M C, Yaqub, M, Barbé, E, Wondergem, M J, Zijlstra, J M, Zweegman, S & Raijmakers, P G 2023, ' Characterizing the Bone Marrow Environment in Advanced-Stage Myelofibrosis during Ruxolitinib Treatment Using PET/CT and MRI : A Pilot Study ', Tomography (Ann Arbor, Mich.), vol. 9, no. 2, pp. 459-474 . https://doi.org/10.3390/tomography9020038
Tomography (Ann Arbor, Mich.), 9(2), 459-474

Current diagnostic criteria for myelofibrosis are largely based on bone marrow (BM) biopsy results. However, these have several limitations, including sampling errors. Explorative studies have indicated that imaging might form an alternative for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a062762c566ad1bc2e20b2c44e12a5
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